29900-93-4 Usage
Description
[1R-(2-endo,3-exo)]-3-amino-1,7,7-trimethylbicyclo[2.2.1]heptan-2-ol is a bicyclic compound characterized by a tertiary amine and a hydroxyl functional group. It is a chiral molecule with a stereocenter at the first carbon atom, and it has a molecular formula of C11H21NO and a molecular weight of 183.29 g/mol. This unique structure and functional groups make it a promising candidate for various applications in organic synthesis, pharmaceuticals, and agrochemicals.
Uses
Used in Organic Synthesis:
[1R-(2-endo,3-exo)]-3-amino-1,7,7-trimethylbicyclo[2.2.1]heptan-2-ol is used as a building block in organic synthesis for the preparation of various pharmaceuticals and agrochemicals. Its unique bicyclic structure and functional groups allow for the creation of a wide range of compounds with potential applications in these industries.
Used in Pharmaceutical Industry:
[1R-(2-endo,3-exo)]-3-amino-1,7,7-trimethylbicyclo[2.2.1]heptan-2-ol is used as a key intermediate in the development of new pharmaceuticals. Its chiral nature and functional groups make it a valuable component in the synthesis of drugs with specific therapeutic properties.
Used in Agrochemical Industry:
[1R-(2-endo,3-exo)]-3-amino-1,7,7-trimethylbicyclo[2.2.1]heptan-2-ol is used as a starting material in the synthesis of agrochemicals, such as pesticides and herbicides. Its unique structure and functional groups can be utilized to create compounds with targeted effects on pests and weeds, improving the efficiency and selectivity of these products.
Used in Medicinal Chemistry and Drug Discovery:
[1R-(2-endo,3-exo)]-3-amino-1,7,7-trimethylbicyclo[2.2.1]heptan-2-ol has potential applications in medicinal chemistry and drug discovery due to its unique bicyclic structure and functional groups. Researchers can explore its use in the development of novel therapeutic agents, particularly those targeting specific biological pathways or receptors.
Check Digit Verification of cas no
The CAS Registry Mumber 29900-93-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,9,9,0 and 0 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 29900-93:
(7*2)+(6*9)+(5*9)+(4*0)+(3*0)+(2*9)+(1*3)=134
134 % 10 = 4
So 29900-93-4 is a valid CAS Registry Number.
29900-93-4Relevant articles and documents
Asymmetric reduction of α-keto aldoxime o -ethers
Bosiak, Mariusz J.,Pakulski, Marcin M.
, p. 316 - 324 (2011/03/18)
The catalytic asymmetric reduction of -keto aldoxime O-methyl, O-benzyl, and O-trityl ethers, derived from substituted acetophenones, with borane/oxazaborolidines, by transfer hydrogenation, and with yeast, was studied. The reduction with borane/oxazaborolidines produced the corresponding -hydroxy oxime ethers, -hydroxy hydroxylamine ethers, and -amino alcohols in 39-78% yields and up to 77% ee. The carbonyl group was selectively reduced by transfer hydrogenation with formic acid-triethylamine catalyzed by RhCl[(R,R)-TsDPEN](Ce, and also with yeast, producing -hydroxy oxime ethers, up to 75% ee and 93% ee, respectively. Georg Thieme Verlag Stuttgart New York.
The practical synthesis of a uterine relaxant, Bis( 2-{[(2S)-2-({(2R)-2-hydroxy-2-[4-hydroxy-3-(2-hydroxyethyl) -phenyl]ethyl}amino) -1,2,3,4-tetrahydronaphthalen-7-yl]oxy}-N,N-dimethylacetamide) sulfate (KUR-1246)
Yanagi, Takashi,Kikuchi, Ken,Takeuchi, Hideki,Ishikawa, Takehiro,Nishimura, Toshihiro,Yamamoto, Iwao
, p. 1018 - 1023 (2007/10/03)
The synthetic route for a uterine relaxant, bis(2-{[ (2S)-2-({(2R)-2-hydroxy-2-[4-hydroxy-3- (2-hydroxyethyl)-phenyl]ethyl}amino) -1,2,3,4-tetrahydronaphthalen-7-y1]oxy}-N,N-dimethylacetamide) sulfate (KUR-1246), was established by the coupling of optically active components, the bromohydrin 14 and the amine 24. We now describe the practical synthesis of these two optically active components. Bromohydrin 14 was obtained by the asymmetric borane reduction of the prochiral phenacyl bromide 13 using a catalyst prepared from aluminum triethoxide and a chiral amino alcohol. The other optically active component 24 was prepared from (S)-AMT.
Preparative scale synthesis of (+) endo-2-hydroxy-endo-3-aminobornane
M'Boungou-M'Passi, A.,Henin, F.,Muzart, J.,Pete, J. P.
, p. 214 - 217 (2007/10/02)
A convenient preparation of the enantiomerically pure title compound is proposed from (+) camphor in 5 steps with an overall yield between 42 and 62percent.The benzoylation of this compound leads to the expected products 6 and 8 and to the oxazoline 10 formed from 6 with retention of configuration.Key Words: chiral 2-hydroxy-3-aminobornanes / benzoylation / acidic hydrolysis
