29903-10-4

Basic information

• Product Name: Benzonitrile, 4,4'-(2-oxo-1,3-propanediyl)bis-
• CAS NO: 29903-10-4
• Molecular Formula: C17H12N2O
• Molecular Weight: 260.295
• Mol File: 29903-10-4.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Benzonitrile, 4,4'-(2-oxo-1,3-propanediyl)bis-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzonitrile, 4,4'-(2-oxo-1,3-propanediyl)bis-(29903-10-4)
• EPA Substance Registry System: Benzonitrile, 4,4'-(2-oxo-1,3-propanediyl)bis-(29903-10-4)

Safety Data

• Hazardous Substances Data: 29903-10-4(Hazardous Substances Data)

Upstream product

• 4755-77-5 Ethyl oxalyl chloride 
• 17201-43-3 4-cyanobenzyl bromide 
• 50-00-0 formaldehyd 
• 70135-28-3 (4-cyanophenyl)diazomethane 
• 1387574-29-9 1-(4-chlorophenyl)-3-(4-cyanophenyl)propane-2-one 
• 201230-82-2 carbon monoxide 
• 79-37-8 oxalyl dichloride 

Downstream Products

• 1621669-60-0 C₃₃H₁₆N₂O 
• 1431085-01-6 C₅₃H₅₈N₂OSi₂ 

Relevant articles and documents

Synthesis of acyclic ketones by catalytic, bidirectional homologation of formaldehyde with nonstabilized diazoalkanes. Application of a chiral diazomethyl(pyrrolidine) in total syntheses of erythroxylon alkaloids

This work offers a catalytic approach to convergent ketone assembly based upon formal and tandem C-H insertion of diazoalkanes in the presence of limiting amounts of monomeric formaldehyde, which is easily generated as a gas by thermolysis of the inexpensive and abundant paraformaldehyde (～30 USD/kg). The method forms di-, tri-, and even tetrasubstituted acetones with high efficiency, and it has streamlined a synthesis of (-)-dihydrocuscohygrine in which the absolute stereochemistry of a proline-based starting material is preserved. Assisted by the advent of new protocols for hydrazone oxidation, we also provide full details on handling non-carbonyl-stabilized diazo compounds.

Antiprotozoal diamidines

Diamidines of the formula STR1 wherein X is a propylene, isobutylene, guanidine, pyrrole, tetrazole, imidazole or substituted imidazole group; and 2-[4-(2-imidazolinyl)phenyl]-6-(2-imidazolinyl)indole, are useful in the treatment of certain protozoal infections in mammals, particularly in cattle.

ACTIVATED METALLIC NICKEL IN PREPARATION OF SYMMETRICAL 1,3-DIARYLPROPAN-2-ONES FROM BENZYLIC HALIDES AND OXALYL CHLORIDES

Oxidative addition of benzylic halides to nickel in the metallic state followed by insertion of carbon monoxide generated from alkyl oxalyl chlorides proceeded smoothly to give symmetrical 1,3-diarylpropan-2-ones in moderate yields.