29936-64-9

Basic information

• Product Name: 2,2,6-trimethyl-4H-benzo[1,4]oxazin-3-one
• CAS NO: 29936-64-9
• Molecular Weight: 191.23
• Mol File: 29936-64-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2,2,6-trimethyl-4H-benzo[1,4]oxazin-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,6-trimethyl-4H-benzo[1,4]oxazin-3-one(29936-64-9)
• EPA Substance Registry System: 2,2,6-trimethyl-4H-benzo[1,4]oxazin-3-one(29936-64-9)

Safety Data

• Hazardous Substances Data: 29936-64-9(Hazardous Substances Data)

Usage

Chemical category

Synthetic chemical

Use

Antimicrobial agent in personal care and household products

Structural relation

Bisphenol A (BPA)

Health concerns

Potential endocrine-disrupting effects

Environmental accumulation

Yes

Detection in humans

Urine, blood, and breast milk

Regulation and restriction

In some countries due to potential health risks.

Upstream product

• 600-00-0 ethyl 2-bromoisobutyrate 
• 95-84-1 3-amino-4-hydroxytoluene 
• 19918-07-1 2-(2-chloro-phenylazo)-4-methyl-phenol 
• 952-47-6 2-hydroxy-5-methylazobenzene 
• 919036-40-1 2-Bromo-N-(2-hydroxy-5-methylphenyl)-2-methylpropanamide 
• 78267-45-5 4-(2-chloroanilino)-2,2,6-trimethyl-1,4-benzoxazin-3(2H)-one 
• 29851-39-6 2-methyl-2-(4-methyl-2-phenylazophenoxy)-2-methylpropanoic acid 
• 29851-49-8 N-[2-methyl-2-(4-methyl-2-phenylazo-phenoxy)-propionyl]-L-valine methyl ester 

Relevant articles and documents

[Omim][BF4], a green and recyclable ionic liquid medium for the one-pot chemoselective synthesis of benzoxazinones

An efficient procedure for the one-pot chemoselective synthesis of 2H-benzo[b][1,4]oxazin-3(4H)-one derivatives from their corresponding o-aminophenols is developed using DBU in the ionic liquid [omim][BF4]. Upon completion of the reaction and separation of the product, the ionic liquid is recovered and successfully reused over nine recycles without any noticeable loss of performance.

Synthesis, biological activity and conformational study of 1,4- benzoxazine derivatives as potassium channel modulators

With the aim of discovering new molecules with K+-channel activating properties, we have synthesized derivatives of cromakalim (CRK), an important molecule which shows specific affinity towards K+ channels, by replacing the benzopyrane ring of this reference compound with a 1,4-benzoxazine moiety. A different number of substituents showing a good discrimination between hydrophobic and electronic properties have been inserted at the 6-position of the 1,4-benzoxazine ring. We describe here the synthesis and discuss the solid state conformation of these new molecules. When tested on rat aorta ring precontracted with phenylephrine, two compounds (2c and 2d) showed a concentration-dependent relaxation similar to that measured for cromakalim but less potent than this reference drug.