29958-12-1 Usage
Description
5-AMINO-2-IODOPYRIDINE is an organic compound with the molecular formula C5H5IN2. It is a heterocyclic compound, specifically a pyridine derivative, which features an amino group at the 5th position and an iodine atom at the 2nd position. 5-AMINO-2-IODOPYRIDINE is known for its potential applications in the pharmaceutical industry due to its unique chemical structure and properties.
Uses
Used in Pharmaceutical Industry:
5-AMINO-2-IODOPYRIDINE is used as a pharmaceutical intermediate for the synthesis of various drugs, particularly in the development of antitumor antibiotics. Its unique structure allows it to serve as a key building block in the creation of more complex and effective pharmaceutical compounds.
Used in Antitumor Antibiotic Synthesis:
5-AMINO-2-IODOPYRIDINE is specifically utilized as an intermediate in the synthesis of the antitumor antibiotic L-azatyrosine. This antibiotic is known for its potential to inhibit the growth of cancer cells and has shown promise in the treatment of various types of cancer. 5-AMINO-2-IODOPYRIDINE's role in the synthesis process is crucial, as it contributes to the overall effectiveness and potency of the final product.
Check Digit Verification of cas no
The CAS Registry Mumber 29958-12-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,9,9,5 and 8 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 29958-12:
(7*2)+(6*9)+(5*9)+(4*5)+(3*8)+(2*1)+(1*2)=161
161 % 10 = 1
So 29958-12-1 is a valid CAS Registry Number.
InChI:InChI=1/C5H5IN2/c6-5-2-1-4(7)3-8-5/h1-3H,7H2
29958-12-1Relevant articles and documents
Copper-catalyzed conversion of aryl and heteroaryl bromides into the corresponding iodide
Feng, Xiujuan,Li, Lingyu,Yu, Xiaoqiang,Yamamoto, Yoshinori,Bao, Ming
, p. 129 - 132 (2016/07/06)
An efficient method for the synthesis of aryl and heteroaryl iodides is described in this study. The reactions of aryl and heteroaryl bromides with potassium iodide proceeded smoothly in the presence of a copper catalyst under mild reaction conditions to produce the corresponding iodides in satisfactory to excellent yields.
Selective catalytic hydrogenation of nitro groups in the presence of activated heteroaryl halides
Kasparian, Annie J.,Savarin, Cecile,Allgeier, Alan M.,Walker, Shawn D.
experimental part, p. 9841 - 9844 (2012/01/06)
Chemoselective reduction of nitro groups in the presence of activated heteroaryl halides was achieved via catalytic hydrogenation with a commercially available sulfided platinum catalyst. The optimized conditions employ low temperature, pressure, and catalyst loading (0.1 mol % Pt) to afford heteroaromatic amines with minimal hydrodehalogenation byproducts.
A revised synthesis of the antitumour antibiotic L-azatyrosine via 2-iodo-5-methoxypyridine
Seton, Alison W.,Stevens, Malcolm F. G.,Westwell, Andrew D.
, p. 546 - 548 (2007/10/03)
A revised synthesis of the antitumour antibiotic L-azatyrosine is reported, the main features of which are the unambiguous synthesis of the previously misinterpreted 2-iodo-5-methoxypyridine and subsequent palladium-catalysed coupling with an iodoalanine-derived zinc reagent.