300-34-5

Basic information

• Product Name: 3-Amino-L-tyrosine
• Synonyms: H-3-NH2-Tyr-OH;(αS)-α,3-Diamino-4-hydroxybenzenepropionic acid;3-Amino-4-hydroxy-L-phenylalanine;3-Amino-4-hydroxyphenylalanine;3-Amino-L-tyrosine;L-Tyr(3-NH3);(2S)-2-amino-3-(3-amino-4-hydroxyphenyl)propanoic acid;(2S)-2-amino-3-(3-amino-4-hydroxy-phenyl)propionic acid
• CAS NO: 300-34-5
• Molecular Formula: C₉H₁₂N₂O₃
• Molecular Weight: 196.2
• Product Categories: Tyrosine [Tyr, Y]
• Mol File: 300-34-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 427.929 °C at 760 mmHg
• Flash Point: 212.604 °C
• Appearance: /
• Density: 1.42 g/cm₃
• Vapor Pressure: 4.38E-08mmHg at 25°C
• Refractive Index: 1.67
• Storage Temp.: 2-8°C
• Solubility: Aquesous Acid (Slightly)
• PKA: 2.15±0.20(Predicted)
• CAS DataBase Reference: 3-Amino-L-tyrosine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Amino-L-tyrosine(300-34-5)
• EPA Substance Registry System: 3-Amino-L-tyrosine(300-34-5)

Safety Data

• Hazardous Substances Data: 300-34-5(Hazardous Substances Data)

Usage

General Description

3-Amino-L-tyrosine is a non-proteinogenic amino acid, which contains an additional amino group in the para position on the benzene ring of tyrosine. It is commonly used as a precursor in the biosynthesis of various natural products and pharmaceuticals. 3-Amino-L-tyrosine has been of interest in the field of medicinal chemistry due to its potential to act as an antioxidant and its ability to enhance the production of neurotransmitters such as dopamine. Additionally, 3-Amino-L-tyrosine has been studied for potential therapeutic applications, such as in the treatment of Parkinson's disease and other neurodegenerative disorders, as well as in the development of new drugs targeting dopamine receptors. Overall, 3-Amino-L-tyrosine represents a valuable chemical compound with diverse biological and pharmacological properties.

InChI:InChI=1/C9H12N2O3/c10-6-3-5(1-2-8(6)12)4-7(11)9(13)14/h1-3,7,12H,4,10-11H2,(H,13,14)

Upstream product

• 621-44-3 3-nitro-L-tyrosine 
• 60-18-4 L-tyrosine 
• 605-65-2 5-(dimethylamino)naphth-1-ylsulfonyl chloride 

Downstream Products

• 725726-11-4 2,2,3,3,4,4,4-Heptafluoro-butyric acid 2-(2,2,3,3,4,4,4-heptafluoro-butyrylamino)-4-[(S)-2-(2,2,3,3,4,4,4-heptafluoro-butyrylamino)-3-(2,2,3,3,4,4,4-heptafluoro-butyryloxy)-3-oxo-propyl]-phenyl ester 
• 685878-63-1 C₉H₁₀N₂O₃ 
• 96844-03-0 3-(3-cyano-4-hydroxyphenyl)-L-alanine 
• 127290-64-6 α-D-L-3-aminotyrosine 
• 127290-64-6 C₉H₁₁⁽²⁾HN₂O₃ 

Relevant articles and documents

Conversion of a Dehalogenase into a Nitroreductase by Swapping its Flavin Cofactor with a 5-Deazaflavin Analogue

Natural and engineered nitroreductases have rarely supported full reduction of nitroaromatics to their amine products, and more typically, transformations are limited to formation of the hydroxylamine intermediates. Efficient use of these enzymes also requires a regenerating system for NAD(P)H to avoid the costs associated with this natural reductant. Iodotyrosine deiodinase is a member of the same structural superfamily as many nitroreductases but does not directly consume reducing equivalents from NAD(P)H, nor demonstrate nitroreductase activity. However, exchange of its flavin cofactor with a 5-deazaflavin analogue dramatically suppresses its native deiodinase activity and leads to significant nitroreductase activity that supports full reduction to an amine product in the presence of the convenient and inexpensive NaBH4.