30058-40-3

Basic information

• Product Name: 2-Fluorobenzenesulfonamide
• Synonyms: 2-FLUOROBENZENE-1-SULFONAMIDE;2-FLUOROBENZENESULFONAMIDE;2-FLUOROBENZENESULPHONAMIDE;LABOTEST-BB LT00408911;BUTTPARK 27\04-30;2-FluoroPhenylsulfonylamine;Benzenesulfonamide, 2-fluoro- (9CI);2-Fluorobenzenesulphonamide 97%
• CAS NO: 30058-40-3
• Molecular Formula: C₆H₆FNO₂S
• Molecular Weight: 175.18
• Product Categories: SULFONAMIDE;Fluorobenzene;Benzenes;Organic Building Blocks;Sulfonamides/Sulfinamides;Sulfur Compounds
• Mol File: 30058-40-3.mol
• Article Data: 6

Chemical Properties

• Melting Point: 162-166 °C(lit.)
• Boiling Point: 317.066 °C at 760 mmHg
• Flash Point: 145.557 °C
• Appearance: /Solid
• Density: 1.429 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 9.69±0.60(Predicted)
• CAS DataBase Reference: 2-Fluorobenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Fluorobenzenesulfonamide(30058-40-3)
• EPA Substance Registry System: 2-Fluorobenzenesulfonamide(30058-40-3)

Safety Data

• Hazard Codes: T,Xn
• Statements: 23/24/25-36/37/38
• Safety Statements: 26-36-45-36/37/39-22
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: Ⅲ
• Hazardous Substances Data: 30058-40-3(Hazardous Substances Data)

Usage

Chemical Properties

White solid

General Description

2-Fluorobenzenesulfonamide can be synthesized by reacting 2-fluorobenzenesulfonyl chloride (in tetrahydrofuran) with 50% NH4OH.

InChI:InChI=1/C6H6FNO2S/c7-5-3-1-2-4-6(5)11(8,9)10/h1-4H,(H2,8,9,10)

Upstream product

• 127159-66-4 sodium 2-fluorobenzenesulfinate 
• 491876-10-9 4-bromo-N-(4,4'-dimethoxytrityl)-2-fluorobenzenesulfonamide 
• 2905-21-7 2-fluorobenzenesulfonyl chloride 
• 214210-30-7 4-bromo-2-fluorobenzenesulfonamide 
• 491876-03-0 C₂₇H₂₅BFNO₆S 
• 31295-65-5 4-bromo-5-methyl-3-phenylisoxazole 

Downstream Products

• 1602577-61-6 N-(2-fluorophenylsulfonyl)-5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-carboxamide 
• 131269-60-8 2-pyrrolidino-benzenesulphonamide 
• 87028-94-2 2-(2-methoxyethylthio)benzenesulfonamide 
• 851169-58-9 2-fluoro-N-methylbenzenesulfonamide 

Relevant articles and documents

NOVEL OXADIAZOLES

The present invention relates to novel oxadiazoles of Formula I, wherein, R1, L1, A, L2 and R10 are as defined in the detailed description.

Design and synthesis of triazolopyrimidine acylsulfonamides as novel anti-mycobacterial leads acting through inhibition of acetohydroxyacid synthase

Novel triazolopyrimidine acylsulfonamides class of antimycobacterial agents, which are mycobacterial acetohydroxyacid synthase (AHAS) inhibitors were designed by hybridization of known AHAS inhibitors such as sulfonyl urea and triazolopyrimidine sulfonamides. This Letter describes the synthesis and SAR studies of this class of molecules by variation of two parts of the molecule, the phenyl and triazolopyrimidine rings. SAR study describes optimisation of enzyme potency, whole cell potency and evidence of mechanism of action.

Convenient Approach to 3,4-Diarylisoxazoles Based on the Suzuki Cross-Coupling Reaction

The Suzuki cross-coupling reaction was found effective for rapid access to a series of 3,4-diarylisoxazoles of pharmacological interest. The efficiency of this approach was demonstrated by the synthesis of the highly potent COX-2-selective inhibitor, 4-(5-methyl-3-phenyl-4-isoxazolyl)benzenesulfonamide (valdecoxib), and its analogues. Thus, the coupling reaction between (3-aryl-5-methyl-4-isoxazolyl)boronic acids, prepared in situ from the corresponding bromides using triisopropyl borate, and aryl bromides containing a 4-sulfonamide or 4-methylsulfonyl group under the standard conditions [Pd(PPh3)4, Na2CO3, EtOH-H2O, reflux] yielded the target 3,4-diarylisoxazoles in good yields.