30065-27-1

Basic information

• Product Name: (2-BENZIMIDAZOLYLTHIO)ACETIC ACID HYDRAZIDE
• Synonyms: LABOTEST-BB LT00453721;AKOS AU36-M70;AKOS BBS-00004095;(2-BENZIMIDAZOLYLTHIO)ACETHYDRAZIDE;(2-BENZIMIDAZOLYLTHIO)ACETIC ACID HYDRAZIDE;(2-BENZIMIDAZOLYTHIO)ACETIC ACID HYDRAZIDE;2-(1H-BENZIMIDAZOL-2-YLTHIO)ACETOHYDRAZIDE;(1H-Benzoimidazol-2-ylsulfanyl)-acetic acid hydrazide
• CAS NO: 30065-27-1
• Molecular Formula: C₉H₁₀N₄OS
• Molecular Weight: 222.27
• Mol File: 30065-27-1.mol
• Article Data: 14

Chemical Properties

• Melting Point: 160°C
• Appearance: /
• Density: 1.46 g/cm³
• Refractive Index: 1.729
• CAS DataBase Reference: (2-BENZIMIDAZOLYLTHIO)ACETIC ACID HYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: (2-BENZIMIDAZOLYLTHIO)ACETIC ACID HYDRAZIDE(30065-27-1)
• EPA Substance Registry System: (2-BENZIMIDAZOLYLTHIO)ACETIC ACID HYDRAZIDE(30065-27-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-36
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 30065-27-1(Hazardous Substances Data)

Usage

General Description

(2-Benzimidazolylthio)acetic acid hydrazide is a chemical compound with the molecular formula C10H10N4OS. It is a hydrazide derivative of (2-benzimidazolylthio)acetic acid, and it has potential applications in pharmaceutical research. (2-BENZIMIDAZOLYLTHIO)ACETIC ACID HYDRAZIDE may have biological activities such as anti-tumor and anti-bacterial properties, but further research is needed to understand its potential uses. It is important for researchers to understand its properties, potential hazards, and synthesis methods in order to safely handle and study this chemical compound.

InChI:InChI=1/C9H10N4OS/c10-13-8(14)5-15-9-11-6-3-1-2-4-7(6)12-9/h1-4H,5,10H2,(H,11,12)(H,13,14)

Upstream product

• 5429-62-9 ethyl 2-(1H-benzo[d]imidazol-2-ylthio)acetate 
• 30956-28-6 2-chloroacetic acid hydrazide 
• 134469-07-1 Benzimidazol-2-thiol 
• 95-54-5 1,2-diamino-benzene 
• 583-39-1 2,3-dihydrobenzimidazol-2-thione 

Downstream Products

• 1226777-41-8 2-(5-pyridin-3-yl-[1,3,4]-oxadiazol-2-ylmethylsulfanyl)-1H-benzimidazole 
• 1226777-42-9 (1H-benzimidazol-2-ylsulfanyl)acetic acid (4-aminobezylidene)hydrazide 
• 1226777-40-7 2-[((5-(2-chloro-4-nitrophenyl)-[1,3,4]-oxadiazole-2-yl)methyl)sulfanyl]-1H-benzimidazole 
• 1226777-38-3 5-[5-((1H-benzimidazol-2-ylsulfanyl)methyl)-[1,3,4]-oxadiazole-2-yl]benzene-1,2,3-triol 
• 30065-39-5 (1H-benzimidazol-2-ylsulfanyl)acetic acid (4-methylbenzylidene)hydrazide 
• 30065-38-4 (1H-benzimidazol-2-ylsulfanyl)acetic acid benzylidene hydrazide 
• 1226777-39-4 4-[5-((1H-benzimidazol-2-ylsulfanyl)methyl)-[1,3,4]-oxadiazole-2-yl]phenylamine 
• 692268-78-3 2-[((5-phenyl-[1,3,4]-oxadiazole-2-yl)methyl)sulfanyl]-1H-benzimidazole 
• 491873-62-2 2-[((5-(4-chlorophenyl)-[1,3,4]-oxadiazole-2-yl)methyl)sulfanyl]-1H-benzimidazole 
• 1226777-36-1 4-[5-((1H-benzimidazol-2-ylsulfanyl)methyl)-[1,3,4]-oxadiazole-2-yl]phenol 
• 904554-37-6 2-[((5-(4-nitrophenyl)-[1,3,4]-oxadiazole-2-yl)methyl)sulfanyl]-1H-benzimidazole 

Relevant articles and documents

Synthesis of Some Novel Benzimidazole Derivatives as Anticancer Agent and Evaluation for CDK2 Inhibition Activity

Background: Thiobezimidazoles reveal various pharmacological activities due to similarities with many natural and synthetic molecules; they can easily interact with biomolecules of living systems. Objective: A series of substituted 2-thiobezimidazoles have been synthesized. Twelve final compounds were screened for in vitro anti-cancer activities against sixty different cell lines. Methods: The spectral data of the synthesized compounds were characterized. A docking study for active anticancer compounds and CDK2/CyclinA2 Kinase assay against standard reference; Imatinib, were performed. Results: Two compounds (3c&3l) from the examined series revealed effective antitumor activity in vitro against two-cancer cell lines (Colon Cancer (HCT-116) and Renal Cancer (TK-10). The docking study of synthesized molecules discovered a requisite binding pose in the CDK-ATP binding pocket .3c &3l were promoted in the CDK2/CyclinA2 Kinase assay against standard reference Imatinib. Conclusion: Against all tested compounds; two compounds 3c &3l were found active against two types of cell-lines.

Synthesis of some new nucleosides derived from 2-mercapto benzimidazole with expected biological activity

2-mercaptobenzimidazole derivatives and their acyclic nucleosides were synthesized. The synthesized compounds were tested for their antibacterial activity against Escherichia coli, Staphylococcus aureus and S. epidermidis. Most of tested compounds showed

Synthesis and pharmacological evaluation of some novel 2-mercapto benzimidazole derivatives

The present study is synthesis of derivatives of N′-(4-amino-5- sulfanyl-4H-1, 2, 4-triazole-3-yl)-2-(1H-benzimi-dazole-2-ylsulfanyl) acetohydrazide (IV). Antibacterial activity tested against the E. coli and A. Substilis. Biological activities conducted