300718-32-5

Basic information

• Product Name: 3-phenyl-2-(2-thienyl)-4(3H)-quinazolinone
• Synonyms: 3-phenyl-2-(2-thienyl)-4(3H)-quinazolinone
• CAS NO: 300718-32-5
• Molecular Formula: C₁₈H₁₂N₂OS
• Molecular Weight: 304.36568
• Mol File: 300718-32-5.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-phenyl-2-(2-thienyl)-4(3H)-quinazolinone(CAS DataBase Reference)
• NIST Chemistry Reference: 3-phenyl-2-(2-thienyl)-4(3H)-quinazolinone(300718-32-5)
• EPA Substance Registry System: 3-phenyl-2-(2-thienyl)-4(3H)-quinazolinone(300718-32-5)

Safety Data

• Hazardous Substances Data: 300718-32-5(Hazardous Substances Data)

Upstream product

• 98-03-3 thiophene-2-carbaldehyde 
• 118-48-9 isatoic anhydride 
• 62-53-3 aniline 
• 4424-17-3 2-aminobenzanilide 

Relevant articles and documents

Method for selectively synthesizing polysubstituted dihydroquinazolinone or quinazolinone

The invention discloses a method for selectively synthesizing polysubstituted dihydroquinazolinone or quinazolinone. According to the method, heteropolyacid ion liquid is taken as a catalyst, microwave heating and solvent-free synthesis technologies are utilized, and dihydroquinazolinone and quinazolinone derivatives are selectively synthesized through a 'one-pot-method' synthetic strategy with isatoic anhydride or derivatives of the isatoic anhydride, amine and aldehyde as raw materials. Compared with the prior art, the method has the multiple advantages that the efficiency is high, the costis low, environmental friendliness is realized, reaction selectivity is good, the product yield is high, selective synthesis can be realized, the catalyst is convenient to recover and apply, operationis easy, and industrial mass production is convenient, and the method is an environment-friendly efficient selective synthesis novel method and meets the environment-friendly and chemical developmentidea.

Development of a New Synthetic Method for Quinazolinones via Aerobic Oxidation in dimethylsulfoxide

The present invention relates to a method for preparing quinazoline derivatives by aerobic oxidation using oxygen as an oxidizing agent in dimethylsulfoxide (DMSO) solvent wherein metal and base are excluded. The method for preparing quinazoline derivatives according to the present invention does not require any metal catalyst such as palladium or iridium, and thus does not cause toxicity problem of residual metal; and does not require demanding processes such as strong acid, or base conditions, low temperature reactions, or reactions of anhydrous conditions and thus, it is possible to simply and economically prepare quinazoline derivatives by reacting anthranilamide derivatives and an aldehyde source.