300831-66-7Relevant articles and documents
Olefin ring-closing metathesis as a powerful tool in drug discovery and development - potent macrocyclic inhibitors of the hepatitis C virus NS3 protease
Tsantrizos, Youla S.,Ferland, Jean-Marie,McClory, Andrew,Poirier, Martin,Farina, Vittorio,Yee, Nathan K.,Wang, Xiao-jun,Haddad, Nizar,Wei, Xudong,Xu, Jinghua,Zhang, Li
, p. 5163 - 5171 (2007/10/03)
Peptidomimetic inhibitors of the hepatitis C NS3 protease often exhibit poor biopharmaceutical properties. Structure modification of a substrate-based tripeptide into a β-strand 15-membered ring scaffold provided a new class of peptidomimetics that are si