30087-33-3Relevant articles and documents
Development of photo-controllable hydrogen sulfide donor applicable in live cells
Fukushima, Naoki,Ieda, Naoya,Kawaguchi, Mitsuyasu,Sasakura, Kiyoshi,Nagano, Tetsuo,Hanaoka, Kenjiro,Miyata, Naoki,Nakagawa, Hidehiko
, p. 175 - 178 (2015)
Hydrogen sulfide (H2S) has multiple physiological roles, for example, in vasodilation and inflammation. It is a highly reactive gas under ambient conditions, so controllable H2S donors are required for studying its biological functions. Here, we describe the design, synthesis and application of a H2S donor (SPD-2) that utilizes xanthone photochemistry to control H2S release. H2S generation from SPD-2 was completely dependent on UVA-irradiation (325-385 nm), as confirmed by methylene blue assay and by the use of a H2S-selective fluorescent probe. SPD-2 was confirmed to provide controlled H2S delivery in live cells, and should be suitable for various biological applications.