30094-32-7

Basic information

• Product Name: diethylphosphonofluoroacetic acid
• Synonyms: diethylphosphonofluoroacetic acid;2-Diethylphosphono-2-fluoroacetic acid;(Diethoxyphosphoryl)(fluoro)acetic acid
• CAS NO: 30094-32-7
• Molecular Formula: C₆H₁₂FO₅P
• Molecular Weight: 214.13
• Mol File: 30094-32-7.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 311℃
• Flash Point: 142℃
• Appearance: /
• Density: 1.298
• CAS DataBase Reference: diethylphosphonofluoroacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: diethylphosphonofluoroacetic acid(30094-32-7)
• EPA Substance Registry System: diethylphosphonofluoroacetic acid(30094-32-7)

Safety Data

• Hazardous Substances Data: 30094-32-7(Hazardous Substances Data)

Usage

General Description

Diethylphosphonofluoroacetic acid is a chemical compound with the molecular formula C6H13FO3P. It is commonly used as a precursor in the synthesis of organophosphorus compounds, which have various industrial and agricultural applications. diethylphosphonofluoroacetic acid is highly toxic and can be used as a chemical warfare agent. It is also classified as a schedule 1 substance under the Chemical Weapons Convention. Due to its hazardous nature, strict regulations and safety measures are required for handling and storage of diethylphosphonofluoroacetic acid.

Upstream product

• 2356-16-3 ethyl(diethylphosphono)(fluoro)acetate 
• 124-38-9 carbon dioxide 
• 65094-25-9 diethyl dibromofluoromethylphosphonate 

Downstream Products

• 598-02-7 Diethyl phosphate 
• 26928-12-1 (Z)-2-fluoro-3-(4-methoxyphenyl)-2-propenoic acid 
• 332-21-8 2-fluoro-5t-phenyl-penta-2ξ,4-dienoic acid 
• 440673-92-7 (2E)-3-cyclohexyl-2-fluoroacrylic acid 
• 412295-21-7 N-[(1-ethoxycarbonylcycloprop-1-yl)carbonylmethyl]-N-[(S)-1-phenylethyl]-2-(diethoxyphosphoryl)-2-fluoroacetamide 
• 337520-67-9 (Z)-3-(3-cyanophenyl)-2-propen-1-ol 
• 131148-37-3 C₁₀H₆FNO₂ 
• 110915-42-9 (Z)-2-fluoro-3-(3-nitrophenyl)acrylic acid 
• 1420407-01-7 diethyl (2-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)amino)-1-fluoro-2-oxoethyl)phosphonate 

Relevant articles and documents

NITROGENOUS HETEROCYCLIC COMPOUND, PREPARATION METHOD, INTERMEDIATE, COMPOSITION, AND APPLICATION

A nitrogenous heterocyclic compound, a preparation method, an intermediate, a composition, and an application. The present invention provides a nitrogenous heterocyclic compound as represented by formula I, pharmaceutically acceptable salts thereof, enantiomers thereof, diastereoisomers thereof, tautomers thereof, solvates thereof, metabolites thereof, or prodrugs thereof. The compound has high inhibitory activity against ErbB2 tyrosine kinase, has good inhibitory activity against human breast cancer cells BT-474, human gastric cancer cells NCI-N87 and the like with high expression of ErbB2, and in addition has relatively weak inhibitory activity against EGFR kinase, that is, the compound is an EGFR/ErbB2 double target inhibitor that attenuates EGFR kinase inhibitory activity or a small-molecule inhibitor having selectivity for an ErbB2 target. (I)

INHIBITORS OF BRUTON'S TYROSINE KINASE

Disclosed herein are compounds that inhibit Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. In addition, reversible inhibitors of Btk are also described. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

An efficient access to (Z)-β-fluoroallyl alcohols based on the two carbon homologation of aromatic aldehydes by Horner-Wadsworth-Emmons reaction with 2-(diethoxyphosphinyl)-2-fluoro-ethanethioic acid, S-ethyl ester followed by reduction with sodium borohy

We describe a biomimetic approach to (Z)-β-fluoroallyl alcohols based on the two carbon homologation of aromatic aldehydes to α-fluorocinnamic thioesters by Horner-Wadsworth-Emmons reaction with 2-(diethoxyphosphinyl)-2- fluoro-ethanethioic acid, S-ethyl