Welcome to LookChem.com Sign In|Join Free

CAS

  • or

302-84-1

Post Buying Request

302-84-1 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

302-84-1 Usage

Description

DL-Serine is a kind of neutral aliphatic amino acids containing hydroxyl groups with polarity but being uncharged, and belongs to nonessential amino acids for human body. It has a high content in sericin silk protein and fibroin protein. It can be formed from the methyl transfer reaction of glycine. It can also be converted to pyruvate or hydroxy pyruvate through deamination. It is also an important raw material for in vivo synthesis of choline and cysteine.

Chemical Properties

DL-Serine is a kind of colorless monoclinic columnar or lamellae crystal. It is soluble in water (at 20℃, the water solubility is 380g/L), insoluble in ether and ethanol; Decomposition point: 246℃.

Uses

Different sources of media describe the Uses of 302-84-1 differently. You can refer to the following data:
1. serine is a hydrophilic amino acid. Serine helps retain the skin’s moisture balance.
2. DL-Serine is used in the synthesis of novel tryptoline derivatives as IDO (indoleamine 2,3-Deoxygenase) inhibitors, for potential use in Alzheimer’s treatment.

Application

Serine is a non-essential amino acid and a natural ligand and allosteric activator of pyruvate kinase M2.DL-Serine is used in the synthesis of novel tryptoline derivatives as IDO (indoleamine 2,3-Deoxygenase) inhibitors, for potential use in Alzheimer?s treatment.

Definition

ChEBI: Serine is an alpha-amino acid that is alanine substituted at position 3 by a hydroxy group. It has a role as a fundamental metabolite. It is an alpha-amino acid and a polar amino acid. It contains a hydroxymethyl group. It is a conjugate base of a serinium. It is a conjugate acid of a serinate. It is a tautomer of a serine zwitterion.

Synthesis Reference(s)

Canadian Journal of Chemistry, 33, p. 1119, 1955 DOI: 10.1139/v55-131The Journal of Organic Chemistry, 35, p. 1505, 1970 DOI: 10.1021/jo00830a054

Biochem/physiol Actions

NMDA agonist acting at the glycine site; precursor of glycine by serine hydroxymethyltransferase

Safety Profile

When heated to decomposition emits toxic fumes of NOx.

in vitro

DL-Serine, a fundamental metabolite, is a mixture of D-Serine and L-Serine. DL-Serine has antiviral activity against the multiplication of tobacco mosaic virus (TMV). Subcutaneous injection of DL-serine increases the number and size of renal tubular cell tumors in male W rats treated with 500 or 1,000 ppm N-ethyl-N-hydroxyethylnitrosamine.

Check Digit Verification of cas no

The CAS Registry Mumber 302-84-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,0 and 2 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 302-84:
(5*3)+(4*0)+(3*2)+(2*8)+(1*4)=41
41 % 10 = 1
So 302-84-1 is a valid CAS Registry Number.
InChI:InChI=1/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1

302-84-1 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • TCI America

  • (S0034)  DL-Serine  >98.0%(T)

  • 302-84-1

  • 25g

  • 103.00CNY

  • Detail
  • TCI America

  • (S0034)  DL-Serine  >98.0%(T)

  • 302-84-1

  • 500g

  • 1,230.00CNY

  • Detail
  • Alfa Aesar

  • (A15184)  DL-Serine, 99%   

  • 302-84-1

  • 100g

  • 422.0CNY

  • Detail
  • Alfa Aesar

  • (A15184)  DL-Serine, 99%   

  • 302-84-1

  • 500g

  • 1763.0CNY

  • Detail
  • Sigma

  • (S4375)  DL-Serine  ≥98% (TLC)

  • 302-84-1

  • S4375-100G

  • 697.32CNY

  • Detail
  • Sigma

  • (S4375)  DL-Serine  ≥98% (TLC)

  • 302-84-1

  • S4375-1KG

  • 5,112.90CNY

  • Detail

302-84-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name serine

1.2 Other means of identification

Product number -
Other names 2-Amino-3-Hydroxypropionicacid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Food additives -> Flavoring Agents
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:302-84-1 SDS

302-84-1Synthetic route

benzyl α-amino-β-hydroxypropionate
1738-71-2

benzyl α-amino-β-hydroxypropionate

serin
302-84-1

serin

Conditions
ConditionsYield
With aluminum oxide at 75℃; for 0.05h; microwave irradiation;92%
5-benzoylamino-5-(1-ethoxycarbonyl-1,4-dihydro-4-pyridyl)-4-oxo-1,3-dioxane
90936-22-4

5-benzoylamino-5-(1-ethoxycarbonyl-1,4-dihydro-4-pyridyl)-4-oxo-1,3-dioxane

serin
302-84-1

serin

Conditions
ConditionsYield
With hydrogenchloride for 6h; Heating;90%
2-amino-3-hydroxypropionitrile
125310-61-4

2-amino-3-hydroxypropionitrile

serin
302-84-1

serin

Conditions
ConditionsYield
With methylamine In water at 150℃; under 22502.3 Torr; for 10h; Autoclave; Inert atmosphere;89.4%
Stage #1: 2-amino-3-hydroxypropionitrile With calcium hydroxide; ammonia In water at 180 - 190℃; under 18751.9 - 22502.3 Torr; for 4h;
Stage #2: With ammonium bicarbonate In water at 40 - 50℃; for 1h; Reagent/catalyst; Temperature; Pressure;
87.9%
L-serin
56-45-1

L-serin

serin
302-84-1

serin

Conditions
ConditionsYield
salicylaldehyde In acetic acid at 80℃; for 5h;86%
With acid Hydrolysis.Racemisierung des in den Proteinen enthaltenen l-Serins bei der Hydrolyse vieler Eiweissstoffe;
With hydrogenchloride; ethanethiol at 110℃; Rate constant; various times;
2-amino-3-hydroxy-propionic acid 9-bora-bicyclo[3.3.1]non-9-yl ester

2-amino-3-hydroxy-propionic acid 9-bora-bicyclo[3.3.1]non-9-yl ester

serin
302-84-1

serin

Conditions
ConditionsYield
Stage #1: 2-amino-3-hydroxy-propionic acid 9-bora-bicyclo[3.3.1]non-9-yl ester With hydrogenchloride In methanol at 20℃; for 0.166667h;
Stage #2: With methyloxirane In methanol; water Further stages.;
62%
formic acid
64-18-6

formic acid

ethylamine
75-04-7

ethylamine

A

serin
302-84-1

serin

B

glycine
56-40-6

glycine

C

rac-Ala-OH
302-72-7

rac-Ala-OH

D

3-amino propanoic acid
107-95-9

3-amino propanoic acid

Conditions
ConditionsYield
In water at 10 - 20℃; for 1h; contact glow discharge electrolysis (500-600 V, 45 mA);A 0.1%
B 0.1%
C 1.5%
D 3.1%
sodium formate
141-53-7

sodium formate

ethylamine
75-04-7

ethylamine

A

serin
302-84-1

serin

B

glycine
56-40-6

glycine

C

rac-Ala-OH
302-72-7

rac-Ala-OH

D

3-amino propanoic acid
107-95-9

3-amino propanoic acid

Conditions
ConditionsYield
In water at 10 - 20℃; for 1h; contact glow discharge electrolysis (500-600 V, 45 mA);A 1%
B 0.3%
C 3.1%
D 0.6%
rac-Ala-OH
302-72-7

rac-Ala-OH

A

serin
302-84-1

serin

B

ASPARAGINE
3130-87-8

ASPARAGINE

C

glycine
56-40-6

glycine

Conditions
ConditionsYield
With sulfuric acid In water at 0 - 10℃; for 1.5h; contact glow discharge electrolysis;A n/a
B 3%
C n/a
With sulfuric acid In water at 0 - 10℃; for 2h; contact glow discharge electrolysis;A 1.8%
B n/a
C n/a
With sulfuric acid In water at 0 - 10℃; for 3h; contact glow discharge electrolysis;
sarcosine
107-97-1

sarcosine

serin
302-84-1

serin

Conditions
ConditionsYield
biochemische Umwandlung;
3-chloro-DL-alanine
3981-36-0

3-chloro-DL-alanine

serin
302-84-1

serin

Conditions
ConditionsYield
With water; silver(l) oxide
3-methoxy-2-aminopropionic acid
19794-53-7

3-methoxy-2-aminopropionic acid

serin
302-84-1

serin

Conditions
ConditionsYield
With hydrogen bromide
ethoxyacetaldehyde
22056-82-2

ethoxyacetaldehyde

serin
302-84-1

serin

Conditions
ConditionsYield
With methanol; hydrogen cyanide; ammonia man verseift das entstandene Aminonitril mit kalter konz.Salzsaeure und kocht die gebildete β-Aethoxy-α-amino-propionsaeure mit Bromwasserstoffsaeure;
acetylamino-hydroxymethyl-malonic acid diethyl ester
6267-40-9

acetylamino-hydroxymethyl-malonic acid diethyl ester

serin
302-84-1

serin

Conditions
ConditionsYield
With sodium hydroxide; water Eindampfen des Reaktionsprodukts mit Essigsaeure und anschliessendes Kochen mit konz.wss.HCl;
1,1-dihydroxyacetone
1186-47-6

1,1-dihydroxyacetone

serin
302-84-1

serin

Conditions
ConditionsYield
With ammonia anschliessend mit wss.H2O2;
N-benzoyl-serine ethyl ester
4783-22-6

N-benzoyl-serine ethyl ester

serin
302-84-1

serin

Conditions
ConditionsYield
With sulfuric acid ueber mehrere Stufen;
With sulfuric acid
methoxymethyl-phthalimido-malonic acid

methoxymethyl-phthalimido-malonic acid

serin
302-84-1

serin

Conditions
ConditionsYield
With hydrogenchloride
O-benzylserine
5445-44-3

O-benzylserine

serin
302-84-1

serin

acetylamino-hydroxymethyl-malonic acid
872790-82-4

acetylamino-hydroxymethyl-malonic acid

acetic acid
64-19-7

acetic acid

serin
302-84-1

serin

Conditions
ConditionsYield
Kochen des Reaktionsprodukts mit konz.wss.HCl;
Glycolaldehyde
141-46-8

Glycolaldehyde

serin
302-84-1

serin

Conditions
ConditionsYield
With ethanol; hydrogen cyanide; ammonia man fuegt waessr.Salzsaeure hinzu und engt die filtrierte Fluessigkeit ein;
With ammonium hydroxide; sodium hydroxide; ammonium chloride In water
formaldehyd
50-00-0

formaldehyd

glycine
56-40-6

glycine

serin
302-84-1

serin

Conditions
ConditionsYield
With copper(II) sulfate
methanol
67-56-1

methanol

A

serin
302-84-1

serin

B

Glutamic acid
617-65-2

Glutamic acid

C

glycine
56-40-6

glycine

D

rac-Ala-OH
302-72-7

rac-Ala-OH

E

aspartic Acid
617-45-8

aspartic Acid

Conditions
ConditionsYield
With water; ammonium chloride; Pt/titania at 27℃; for 72h; Product distribution; Irradiation; other reagent;
2-Amino-1-propanol
6168-72-5

2-Amino-1-propanol

A

DL-2-amino-propionaldehyde
4744-12-1

DL-2-amino-propionaldehyde

B

serin
302-84-1

serin

C

glycine
56-40-6

glycine

D

rac-Ala-OH
302-72-7

rac-Ala-OH

Conditions
ConditionsYield
With argon arc plasma; water at 30℃; Product distribution; tungsten rod cathode, copper nozzle anode, 40 A, 10 V, pH= 3; variation of the time;
2-Amino-1-propanol
6168-72-5

2-Amino-1-propanol

A

DL-2-amino-propionaldehyde
4744-12-1

DL-2-amino-propionaldehyde

B

serin
302-84-1

serin

C

rac-Ala-OH
302-72-7

rac-Ala-OH

Conditions
ConditionsYield
O2+H2 In water at 40 - 50℃; for 0.5h;A n/a
B n/a
C 16.0 % Chromat.
town gas-oxigen flame In water at 40 - 50℃; for 0.5h;A 18.6 % Chromat.
B n/a
C n/a
O2+H2 In water at 40 - 50℃; for 1h;A n/a
B 2.20 % Chromat.
C n/a
methyl-cycloserine
2076-49-5

methyl-cycloserine

A

formaldehyd
50-00-0

formaldehyd

B

serin
302-84-1

serin

C

Glycolaldehyde
141-46-8

Glycolaldehyde

D

methylamine
74-89-5

methylamine

Conditions
ConditionsYield
With Carbonate buffer Product distribution; controlled potential electrolysis: glassy-carbon plate electrode, pH 10;
methane
34557-54-5

methane

A

serin
302-84-1

serin

B

Glutamic acid
617-65-2

Glutamic acid

C

glycine
56-40-6

glycine

D

rac-Ala-OH
302-72-7

rac-Ala-OH

E

aspartic Acid
617-45-8

aspartic Acid

Conditions
ConditionsYield
With ammonium hydroxide; Pt/titania at 27℃; for 216h; Product distribution; Irradiation; other reagent, time;
ethanol
64-17-5

ethanol

A

serin
302-84-1

serin

B

Glutamic acid
617-65-2

Glutamic acid

C

glycine
56-40-6

glycine

D

aspartic Acid
617-45-8

aspartic Acid

Conditions
ConditionsYield
With water; ammonium chloride; Pt/titania at 27℃; for 120h; Product distribution; Irradiation;
3-aminobutyric acid
2835-82-7

3-aminobutyric acid

A

3-hydroxyaspartic acid
71653-06-0

3-hydroxyaspartic acid

B

serin
302-84-1

serin

C

(3-S)-3-Amino-2-hydroxybutanoic acid
565-81-1

(3-S)-3-Amino-2-hydroxybutanoic acid

D

3-Amino-4-hydroxybutyric Acid
589-44-6

3-Amino-4-hydroxybutyric Acid

E

rac-Ala-OH
302-72-7

rac-Ala-OH

F

aspartic Acid
617-45-8

aspartic Acid

Conditions
ConditionsYield
In water at 20℃; for 0.666667h; Mechanism; oxidative degradation by contact glow discharge electrolysis, further byproducts;A 0.7 % Chromat.
B 0.9 % Chromat.
C 1.2 % Chromat.
D 13.7 % Chromat.
E 4.9 % Chromat.
F 1.6 % Chromat.
O-phospho-DL-serine
17885-08-4

O-phospho-DL-serine

serin
302-84-1

serin

Conditions
ConditionsYield
With water at 30℃; for 0.166667h; Rate constant; relative rate, different alkaline phosphotases;
With mono-p-nitrophenyl phosphate; D-Sorbose; 2-amino-ethanol hydrochloride; magnesium chloride In water at 25℃; for 0.0833333h; Rate constant;
β-nitroaminoalanine
82863-40-9

β-nitroaminoalanine

A

serin
302-84-1

serin

B

3-chloro-DL-alanine
3981-36-0

3-chloro-DL-alanine

Conditions
ConditionsYield
With hydrogenchloride for 18h; Heating;A 5.5 mg
B n/a
With hydrogenchloride for 18h; Heating;A 5.5 mg
B 5.5 mg
serin
302-84-1

serin

pyrroloquinoline quinone
72909-34-3

pyrroloquinoline quinone

C15H7N3O7
132847-84-8

C15H7N3O7

Conditions
ConditionsYield
In water at 30℃; for 24h; pH = 9.7;100%
With air; cetyltrimethylammonim bromide at 30℃;55%
[4,5,6,7-2H4]indole
73509-22-5

[4,5,6,7-2H4]indole

serin
302-84-1

serin

acetic anhydride
108-24-7

acetic anhydride

acetic acid
64-19-7

acetic acid

Nb-acetyl-DL-[4',5',6',7'-(2)H4]tryptophan
1190220-65-5

Nb-acetyl-DL-[4',5',6',7'-(2)H4]tryptophan

Conditions
ConditionsYield
for 2h; Inert atmosphere; Reflux;99%
methanol
67-56-1

methanol

serin
302-84-1

serin

methyl 2-amino-3-hydroxypropanoate hydrochloride
5619-04-5

methyl 2-amino-3-hydroxypropanoate hydrochloride

Conditions
ConditionsYield
With acetyl chloride for 2h; Reflux;98%
With thionyl chloride at 0 - 20℃; Inert atmosphere;95%
With thionyl chloride for 19h; Time; Cooling with ice; Reflux;94.2%
serin
302-84-1

serin

isopropyl alcohol
67-63-0

isopropyl alcohol

(+/-)-3-hydroxyl-1-isopropoxycarbonylprop-2-amine hydrochloride
103292-59-7

(+/-)-3-hydroxyl-1-isopropoxycarbonylprop-2-amine hydrochloride

Conditions
ConditionsYield
With thionyl chloride Reflux;96.9%
With hydrogenchloride92%
With hydrogenchloride at 85℃; for 12h;
With hydrogenchloride at 85℃; for 12h;
With hydrogenchloride at 85℃; for 12h;
serin
302-84-1

serin

chloroacetic acid
79-11-8

chloroacetic acid

N,N-bis(carboxymethyl)serine trisodium salt

N,N-bis(carboxymethyl)serine trisodium salt

Conditions
ConditionsYield
Stage #1: serin With sodium hydroxide In water at 61.5℃; for 1.25h; pH=9.3 - 9.8;
Stage #2: chloroacetic acid In water at 62 - 65℃; for 2.5h;
Stage #3: With potassium iodide In water at 92℃; for 5.5h;
96.9%
Conditions
ConditionsYield
With thionyl chloride at 0 - 20℃;96%
With thionyl chloride at 0℃; for 3h; Reflux; Inert atmosphere;90%
With hydrogenchloride man verdampft unter geringem Druck, zersetzt das entstandene Hydrochlorid durch eine 2prozentige Loesung von Natrium in Methylalkohol und verdampft das Filtrat unter geringem Druck bei gewoehnlicher Temp.;
serin
302-84-1

serin

3-(trimethylsilyl)propynoyl chloride
66224-70-2

3-(trimethylsilyl)propynoyl chloride

3-hydroxy-2-{[3-(trimethylsilyl)prop-2-ynoyl]amino}propanoic acid

3-hydroxy-2-{[3-(trimethylsilyl)prop-2-ynoyl]amino}propanoic acid

Conditions
ConditionsYield
Stage #1: serin With sulfuric acid; 1,1,1,3,3,3-hexamethyl-disilazane for 0.333333h; Heating;
Stage #2: 3-(trimethylsilyl)propynoyl chloride In diethyl ether at 20℃; for 1h;
Stage #3: With water In diethyl ether
95%
serin
302-84-1

serin

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

N-Boc-DL-serine
3850-40-6

N-Boc-DL-serine

Conditions
ConditionsYield
With sodium hydroxide In water at 0 - 27℃;94.7%
With sodium hydroxide In 1,4-dioxane at 0 - 20℃; for 72h; pH=9;78%
With sodium hydroxide In water at 0 - 27℃; Industry scale;
3,4-epoxy-4-methyltetrahydropyran
33331-97-4, 134309-95-8

3,4-epoxy-4-methyltetrahydropyran

serin
302-84-1

serin

3-Hydroxy-2-((3S,4S)-4-hydroxy-4-methyl-tetrahydro-pyran-3-ylamino)-propionic acid
129673-43-4

3-Hydroxy-2-((3S,4S)-4-hydroxy-4-methyl-tetrahydro-pyran-3-ylamino)-propionic acid

Conditions
ConditionsYield
With sodium hydroxide In water at 80℃; for 4h;94%
serin
302-84-1

serin

2,2'-dihydroxybenzophenone
835-11-0

2,2'-dihydroxybenzophenone

tetramethyl ammoniumhydroxide
75-59-2

tetramethyl ammoniumhydroxide

C4H12N(1+)*C16H14NO5(1-)
1101869-93-5

C4H12N(1+)*C16H14NO5(1-)

Conditions
ConditionsYield
In methanol at 20℃; for 3h;94%
Indole-3-carboxaldehyde
487-89-8

Indole-3-carboxaldehyde

serin
302-84-1

serin

C16H20N3O2(1+)*Cl(1-)

C16H20N3O2(1+)*Cl(1-)

copper dichloride

copper dichloride

C28H32Cl2CuN5O5(1+)*Cl(1-)

C28H32Cl2CuN5O5(1+)*Cl(1-)

Conditions
ConditionsYield
In methanol; water at 20℃; for 24h; Temperature; Resolution of racemate; enantioselective reaction;94%
serin
302-84-1

serin

hydrogen fluoride
7664-39-3

hydrogen fluoride

water
7732-18-5

water

antimony(III) fluoride
7783-56-4

antimony(III) fluoride

DL-serinium heptafluorodiantimonate(III)

DL-serinium heptafluorodiantimonate(III)

Conditions
ConditionsYield
at 50 - 60℃; pH=1 - 2;93%
serin
302-84-1

serin

butan-1-ol
71-36-3

butan-1-ol

D,L-Serine butyl ester hydrochloride
52779-16-5

D,L-Serine butyl ester hydrochloride

Conditions
ConditionsYield
With hydrogenchloride room temp., 40 h; reflux, 8 h;92%
serin
302-84-1

serin

o-phthalic dicarboxaldehyde
643-79-8

o-phthalic dicarboxaldehyde

3-hydroxy-2-(1-oxoisoindolin-2-yl)propanoic acid

3-hydroxy-2-(1-oxoisoindolin-2-yl)propanoic acid

Conditions
ConditionsYield
With acetic acid for 0.166667h; Heating;91%
serin
302-84-1

serin

C27H22N4O3

C27H22N4O3

tetramethyl ammoniumhydroxide
75-59-2

tetramethyl ammoniumhydroxide

C4H12N(1+)*C30H26N5O5(1-)

C4H12N(1+)*C30H26N5O5(1-)

Conditions
ConditionsYield
In methanol at 20℃; for 3h;90%
diisopropyl hydrogenphosphonate
1809-20-7

diisopropyl hydrogenphosphonate

serin
302-84-1

serin

2-(Diisopropoxy-phosphorylamino)-3-hydroxy-propionic acid
117286-89-2

2-(Diisopropoxy-phosphorylamino)-3-hydroxy-propionic acid

Conditions
ConditionsYield
With sodium hydroxide; sodium hypochlorite; tetrabutylammomium bromide In water at 0 - 5℃; for 6h; pH=9.0 - 9.5;89%
9-fluorenylmethyl 4,6-dimethoxy-1,3,5-triazinyl carbonate
909114-66-5

9-fluorenylmethyl 4,6-dimethoxy-1,3,5-triazinyl carbonate

serin
302-84-1

serin

N-(9-fluorenylmethoxycarbonyl)-DL-serine
136083-72-2

N-(9-fluorenylmethoxycarbonyl)-DL-serine

Conditions
ConditionsYield
With sodium carbonate In acetonitrile at 20℃; for 0.666667h;89%
serin
302-84-1

serin

benzaldehyde
100-52-7

benzaldehyde

(RS)-N-benzylserine
106910-76-3

(RS)-N-benzylserine

Conditions
ConditionsYield
Stage #1: serin; benzaldehyde With sodium hydroxide In water at 20℃; for 1h;
Stage #2: With sodium tetrahydroborate In water at 5 - 20℃; for 1.5h;
88%
Stage #1: serin; benzaldehyde With sodium hydroxide In water for 0.5h;
Stage #2: With sodium tetrahydroborate at 20℃; for 4h; Cooling with ice;
40%
With sodium hydroxide; sodium tetrahydroborate 1) 30 min; 2) 6-10 deg C, 1+1+1+2 h; Yield given. Multistep reaction;
serin
302-84-1

serin

sodium 4-chloro-3-nitro-5-(trifluoromethyl)benzenesulfonate

sodium 4-chloro-3-nitro-5-(trifluoromethyl)benzenesulfonate

2-(2-nitro-4-sulfo-6-(trifluoromethyl)phenylamino)-3-hydroxypropanoic acid

2-(2-nitro-4-sulfo-6-(trifluoromethyl)phenylamino)-3-hydroxypropanoic acid

Conditions
ConditionsYield
With sodium hydrogencarbonate In water at 100℃; for 18h;87%
serin
302-84-1

serin

2-pyrrolidin-1-ylbenzaldehyde
58028-74-3

2-pyrrolidin-1-ylbenzaldehyde

3-hydroxy-2-(1,2,3,3a-tetrahydropyrrolo[1,2-a]quinazolin-4(5H)-yl)propanoic acid

3-hydroxy-2-(1,2,3,3a-tetrahydropyrrolo[1,2-a]quinazolin-4(5H)-yl)propanoic acid

Conditions
ConditionsYield
With 2,2,2-trifluoroethanol at 20℃;87%
serin
302-84-1

serin

9-borabicyclo[3.3.1]nonane
280-64-8

9-borabicyclo[3.3.1]nonane

2-amino-3-hydroxy-propionic acid 9-bora-bicyclo[3.3.1]non-9-yl ester

2-amino-3-hydroxy-propionic acid 9-bora-bicyclo[3.3.1]non-9-yl ester

Conditions
ConditionsYield
In methanol for 3h; Heating;86%
N-phenyl-maleimide
941-69-5

N-phenyl-maleimide

serin
302-84-1

serin

salicylaldehyde
90-02-8

salicylaldehyde

2-hydroxymethyl-4-o-hydroxyphenyl-6,8-dioxo-7-phenyl-3,7-diazabicyclo<3.3.0>octane-2-carboxylic acid
88967-46-8

2-hydroxymethyl-4-o-hydroxyphenyl-6,8-dioxo-7-phenyl-3,7-diazabicyclo<3.3.0>octane-2-carboxylic acid

Conditions
ConditionsYield
With acetic acid In methanol; toluene for 2h; Reflux; stereospecific reaction;86%
bismuth(III) tert-butoxide

bismuth(III) tert-butoxide

serin
302-84-1

serin

water
7732-18-5

water

tris-(2-amino-3-hydroxypropanoato) bismuth(III) monohydrate

tris-(2-amino-3-hydroxypropanoato) bismuth(III) monohydrate

Conditions
ConditionsYield
In tetrahydrofuran at -78 - 20℃; for 3h; Inert atmosphere; Schlenk technique; Cooling with ethanol-dry ice;86%
serin
302-84-1

serin

1-tert-butoxycarbonyloxybenzotriazole
89037-64-9

1-tert-butoxycarbonyloxybenzotriazole

N-Boc-DL-serine
3850-40-6

N-Boc-DL-serine

Conditions
ConditionsYield
With triethylamine In 1,4-dioxane; water for 0.166667h; Ambient temperature;85%
serin
302-84-1

serin

4-chloro-5,6-dimethyl-thieno[2,3-d]pyrimidine
108831-68-1

4-chloro-5,6-dimethyl-thieno[2,3-d]pyrimidine

2-(5,6-dimethylthieno[2,3-d]pyrimidin-4-ylamino)-3-hydroxy-propionic acid

2-(5,6-dimethylthieno[2,3-d]pyrimidin-4-ylamino)-3-hydroxy-propionic acid

Conditions
ConditionsYield
Stage #1: serin With sodium carbonate In water pH=9 - 9.5;
Stage #2: 4-chloro-5,6-dimethyl-thieno[2,3-d]pyrimidine In water at 100℃; for 6h; pH=9 - 9.5;
85%

302-84-1Relevant articles and documents

Catalytic mechanism of serine racemase from Dictyostelium discoideum

Ito, Tomokazu,Maekawa, Motoki,Hayashi, Shuhei,Goto, Masaru,Hemmi, Hisashi,Yoshimura, Tohru

, p. 1073 - 1084 (2013)

The eukaryotic serine racemase from Dictyostelium discoideum is a fold-type II pyridoxal 5′-phosphate (PLP)-dependent enzyme that catalyzes racemization and dehydration of both isomers of serine. In the present study, the catalytic mechanism and role of the active site residues of the enzyme were examined by site-directed mutagenesis. Mutation of the PLP-binding lysine (K56) to alanine abolished both serine racemase and dehydrase activities. Incubation of d- and l-serine with the resultant mutant enzyme, K56A, resulted in the accumulation of PLP-serine external aldimine, while less amounts of pyruvate, α-aminoacrylate, antipodal serine and quinonoid intermediate were formed. An alanine mutation of Ser81 (S81) located on the opposite side of K56 against the PLP plane converted the enzyme from serine racemase to l-serine dehydrase; S81A showed no racemase activity and had significantly reduced d-serine dehydrase activity, but it completely retained its l-serine dehydrase activity. Water molecule(s) at the active site of the S81A mutant enzyme probably drove d-serine dehydration by abstracting the α-hydrogen in d-serine. Our data suggest that the abstraction and addition of α-hydrogen to l- and d-serine are conducted by K56 and S81 at the si- and re-sides, respectively, of PLP.

Metal ion dependency of serine racemase from Dictyostelium discoideum

Ito, Tomokazu,Murase, Hirotaka,Maekawa, Motoki,Goto, Masaru,Hayashi, Shuhei,Saito, Hajime,Maki, Masatoshi,Hemmi, Hisashi,Yoshimura, Tohru

, p. 1567 - 1576 (2012)

d-Serine is known to act as an endogenous co-Agonist of the N-methyl-d-Aspartate receptor in the mammalian brain and is endogenously synthesized from l-serine by Apyridoxal 5′-phosphate-dependent enzyme, serine racemase. Though the soil-living mycetozoa Dictyostelium discoideum possesses no genes homologous to that of NMDA receptor, it contains genes encoding putative proteins relating to the d-serine metabolism, such as serine racemase, d-Amino acid oxidase, and d-serine dehydratase. D. discoideum is an attractive target for the elucidation of the unknown functions of d-serine such as Arole in cell development. As part of the elucidation of the role of d-serine in D. discoideum, we cloned, overexpressed, and examined the properties of the putative serine racemase exhibiting 46% amino acid sequence similarity with the human enzyme. The enzyme is unique in its stimulation by monovalent cations such as Na+ in addition to Mg2+ and Ca2+, which are well-known activators for the mammalian serine racemase. Mg2+ or Na+ binding caused two- to ninefold enhancement of the rates of both racemization and dehydration. The half-maximal activation concentrations of Mg2+ and Na+ were determined to be 1.2 μM and 2.2 mM, respectively. In the l-serine dehydrase reaction, Mg2+ and Na + enhanced the k cat value without changing the K m value. Alanine mutation of the residues E207 and D213, which correspond to the Mg2+-binding site of Schizosaccharomyces pombe serine racemase, abolished the Mg2+- and Na+-dependent stimulation. These results suggest that Mg2+ and Na+ share the common metal ion-binding site.

Direct monitoring of biocatalytic deacetylation of amino acid substrates by1H NMR reveals fine details of substrate specificity

De Cesare, Silvia,McKenna, Catherine A.,Mulholland, Nicholas,Murray, Lorna,Bella, Juraj,Campopiano, Dominic J.

supporting information, p. 4904 - 4909 (2021/06/16)

Amino acids are key synthetic building blocks that can be prepared in an enantiopure form by biocatalytic methods. We show that thel-selective ornithine deacetylase ArgE catalyses hydrolysis of a wide-range ofN-acyl-amino acid substrates. This activity was revealed by1H NMR spectroscopy that monitored the appearance of the well resolved signal of the acetate product. Furthermore, the assay was used to probe the subtle structural selectivity of the biocatalyst using a substrate that could adopt different rotameric conformations.

Preparation and purification method of amino acid compound

-

Paragraph 0058; 0059; 0072; 0073; 0074; 0075, (2018/06/21)

The invention relates to the field of industrial organic synthesis, in particular to a preparation and purification method of an amino acid compound. The method comprises the following steps that (1)alpha-amino nitrile compounds or hydantoin compounds or mixtures thereof are heated to react to obtain alpha-amino acid salt under the condition that volatile alkali and a suitable solvent exist; (2)after the alpha-amino acid salt obtained in step (1) is distilled, the alpha-amino acid salt is recrystallized in an organic solvent to obtain the alpha-amino acid compound. According to the method, reaction conditions are mild, materials can be recycled, and introduction of metal ions and use of ammonium carbonate salt are avoided, so that post-treatment is simple and no waste salt is generated.

Degradation of complexons derived from succinic acid under UV radiation

Smirnova,Khizhnyak,Nikol’skii,Khalyapina, Ya. M.,Pakhomov

, p. 507 - 511 (2017/08/02)

The destruction of complexons derived from succinic acid under the action of UV radiation was studied. IR spectroscopy, thin-layer paper chromatography, and complexometric titration were used to determine the destruction products of these complexons. It was found that the complexons decompose under UV irradiation substantially more easily than ethylenediaminetetraacetic acid does, and the products of their decomposition can undergo a biological utilization under natural conditions. The data obtained in the study make it possible to choose, instead of ethylenediaminetetraacetic acid, ligands that will be nearly fully destructible in the light without deteriorating the ecology.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 302-84-1