30216-51-4

Basic information

• Product Name: 2-HYDRAZINO-1,3-THIAZOLE
• Synonyms: 2-Hydrazinylthiazole;1,3-thiazol-2-ylhydrazine
• CAS NO: 30216-51-4
• Molecular Formula: C₃H₅N₃S
• Molecular Weight: 115.16
• Mol File: 30216-51-4.mol
• Article Data: 5

Chemical Properties

• Melting Point: 96-98 °C
• Boiling Point: 252.3±23.0 °C(Predicted)
• Appearance: /
• Density: 1.58±0.1 g/cm3(Predicted)
• PKA: 0.67±0.20(Predicted)
• CAS DataBase Reference: 2-HYDRAZINO-1,3-THIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDRAZINO-1,3-THIAZOLE(30216-51-4)
• EPA Substance Registry System: 2-HYDRAZINO-1,3-THIAZOLE(30216-51-4)

Safety Data

• Hazardous Substances Data: 30216-51-4(Hazardous Substances Data)

Usage

General Description

2-Hydrazino-1,3-thiazole is a chemical compound with the molecular formula C3H5N3S. It is a heterocyclic organic compound containing a thiazole ring and a hydrazine functional group. 2-HYDRAZINO-1,3-THIAZOLE is known for its application in the synthesis of pharmaceuticals and agrichemicals. It has also been studied for its potential as a corrosion inhibitor for metal surfaces. 2-Hydrazino-1,3-thiazole is a versatile building block that can be used in the preparation of various other organic compounds, making it a valuable tool in the field of organic chemistry.

Upstream product

• 79-19-6 thiosemicarbazide 
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Downstream Products

• 307542-89-8 2-bromo-6-methoxy-4-(thiazol-2-yl-hydrazonomethyl)phenol 
• 347914-49-2 2,6-dimethoxy-4-(thiazol-2-yl-hydrazonomethyl)phenol 
• 1068515-45-6 3-methyl-4-phenyl-1-(thiazol-2-yl)-1H-pyrazol-5-ol 
• 957655-56-0 C₂₀H₁₄N₄O₂S 
• 114151-36-9 5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-(3-oxobutyl)-pyrazole thiazol-2-yl hydrazone 
• 30216-55-8 1-phenyl-ethanone thiazol-2-ylhydrazone 
• 89408-16-2 2-[1-(Thiazol-2-yl-hydrazono)-ethyl]-phenol 

Relevant articles and documents

Synthesis of 2-anilinopyridyl linked benzothiazole hydrazones as apoptosis inducing cytotoxic agents

A series of 2-anilinopyridyl linked benzothiazole-hydrazone conjugates (5a-aa) were designed, synthesized and evaluated for their in vitro cytotoxic potency against a panel of cancer cell lines like mouse skin melanoma (B16F10), lung adenocarcinoma (A549), breast adenocarcinoma (MCF-7), triple negative breast cancer (MDA-MB-231) and normal lung epithelial (L132) cell lines. Preliminary screening results revealed that some of these conjugates like 5i and 5l exhibited a significant antiproliferative effect against human breast cancer (MCF-7) with IC50 values of 1.03 and 1.69 μM respectively. Further, detailed biological studies of this promising conjugate (5i) were carried out on MCF-7 cells. The flow cytometric analysis revealed that this conjugate induces cell-cycle arrest in the G2/M phase in a dose dependent manner. Furthermore, in order to determine the effect of the conjugate on cell viability, various cell based assays such as clonogenic assay, ethidium bromide staining, Hoechst staining, detection of ROS generation and annexin V-FITC/PI assays were performed. In these studies, apoptotic features were clearly observed indicating that this conjugate inhibited cell proliferation by apoptosis.

PYRAZOLE AND PYRROLE COMPOUNDS USEFUL IN TREATING IRON DISORDERS

This invention is directed to pyrazole and pyrrole compounds, for example, compounds of formula (I): wherein R1, R2, R3 and R4 are as defined herein, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of iron disorders. This invention is also directed to pharmaceutical compositions comprising the compounds and methods of using the compounds to treat iron disorders.

3-[1-(2-Benzoxazolyl)hydrazino]propanenitrile derivatives: Inhibitors of immune complex induced inflammation

3-[1-(2-Benzoxazolyl)hydrazino]propanenitrile derivatives were evaluated in the dermal and pleural reverse passive Arthus reactions in the rat. In the pleural test these compounds were effective in reducing exudate volume and accumulation of white blood cells. This pattern of activity was similar to that of hydrocortisone and different from that of indomethacin. The structural requirements for inhibiting the Arthus reactions were studied by systematic chemical modification of 1. These structure-activity relationship studies revealed that nitrogen 1' of the hydrazino group is essential for activity and must be electron rich, whereas chemical modifications of other sites of 1 had only a modest effect on activity.