30235-26-8

Basic information

• Product Name: 4-PYRIDIN-2-YL-THIAZOL-2-YLAMINE
• Synonyms: 4-(2-PYRIDINYL)-1,3-THIAZOL-2-AMINE;4-PYRIDIN-2-YL-1,3-THIAZOL-2-AMINE;4-PYRIDIN-2-YL-THIAZOL-2-YLAMINE;2-AMINO-4-(2-PYRIDYL)THIAZOLE;IFLAB-BB F0447-0233;BUTTPARK 29\06-84;TIMTEC-BB SBB010613;4-(Pyridin-2-yl)thiazol-2-amine
• CAS NO: 30235-26-8
• Molecular Formula: C₈H₇N₃S
• Molecular Weight: 177.23
• Mol File: 30235-26-8.mol
• Article Data: 6

Chemical Properties

• Melting Point: 173-174 °C(Solv: ethanol, 50% (64-17-5))
• Boiling Point: 383.6 °C at 760 mmHg
• Flash Point: 185.8 °C
• Appearance: Pale brown/Solid
• Density: 1.333 g/cm³
• Vapor Pressure: 4.36E-06mmHg at 25°C
• Refractive Index: 1.669
• Storage Temp.: 2-8°C(protect from light)
• PKA: 3.40±0.10(Predicted)
• CAS DataBase Reference: 4-PYRIDIN-2-YL-THIAZOL-2-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-PYRIDIN-2-YL-THIAZOL-2-YLAMINE(30235-26-8)
• EPA Substance Registry System: 4-PYRIDIN-2-YL-THIAZOL-2-YLAMINE(30235-26-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 30235-26-8(Hazardous Substances Data)

Usage

General Description

4-Pyridin-2-yl-thiazol-2-ylamine is a chemical compound with the molecular formula C8H7N3S. It belongs to the class of heterocyclic compounds containing a pyridine ring and a thiazole ring, making it a potential scaffold for drug design and development. 4-PYRIDIN-2-YL-THIAZOL-2-YLAMINE has been studied for its potential use in medicinal chemistry and pharmaceutical research, as it exhibits interesting biological activities and is a promising candidate for the synthesis of new therapeutic agents. Its unique structure and functional groups make it a versatile building block for the synthesis of various biologically active compounds, and it has the potential for further exploration in the field of drug discovery.

InChI:InChI=1/C8H7N3S/c9-8-11-7(5-12-8)6-3-1-2-4-10-6/h1-5H,(H2,9,11)

Upstream product

• 40086-66-6 2-Bromoacetylpyridine 
• 17356-08-0 thiourea 

Downstream Products

• 372093-86-2 N-[4-(2-Pyridyl)thiazol-2-yl)-(2-chloro-5-nitrophenyl)carboxamide 
• 1610339-53-1 4-formyl-N-[4-(pyridin-2-yl)-1,3-thiazol-2-yl]benzamide 

Relevant articles and documents

Synthesis, cytotoxicity and anti-metastatic properties of new pyridyl–thiazole arene ruthenium(II) complexes

A series of novel ruthenium(II)–cymene complexes (1–8) containing substituted pyridyl–thiazole ligands, [Ru(η6-p-cymene)(L)Cl]Cl (L = N,N-chelating derivatives), have been synthesized and characterized using elemental analysis, infrared, 1H NMR and 13C NMR spectroscopies and mass spectrometry. All these complexes not only display marked cytotoxicity in vitro against three different human cancer cell lines (HeLa, A549 and MDA-MB-231), but also exhibit promising anti-metastatic activity at sub-cytotoxic concentrations. Cell cycle analysis shows that the ruthenium(II) complex-induced growth inhibition was mainly caused by S-phase cell cycle arrest. Further protein level analysis suggests that compound 5 may exert antitumor activity via a p53-independent mechanism.

Substituted 1,3-miscellaneous azole compound, preparation method thereof, pharmaceutical composition containing substituted 1,3-miscellaneous azole compound and purpose thereof

The invention relates to a substituted 1,3-miscellaneous azole compound, a preparation method thereof, a pharmaceutical composition containing the substituted 1,3-miscellaneous azole compound and a purpose thereof. The invention relates to the compound in a formula I, or its pharmaceutically acceptable salt, a stereisomer or a solvate, wherein R1, R2, R3 and X are defined as a specification; and the invention also relates to the preparation method, the pharmaceutical composition containing the substituted 1,3-miscellaneous azole compound and the purpose thereof. The compound of the present invention is the novel antituberculous compound, is effective to mycobacterium tuberculosis-susceptible strains, also possesses activity on strains with tolerance on traditional first-line antituberculous drugs such as isoniazide and rifampicin, and has good selectivity to mycobacterium tuberculosis.

Convenient and simple synthesis of 2-aminothiazoles by the reaction of α-halo ketone carbonyls with ammonium thiocyanate in the presence of N-methylimidazole

Substituted 2-aminothiazole derivatives were obtained as a result of N-methylimidazole catalyzed cyclization of α-halo ketone carbonyls with ammonium thiocyanate in water-alcoholic media. The generality of the method has been demonstrated by screening a series of aromatic/heteroaromatic/aliphatic α-halo ketones, α-halo β-diketones, and α-halo β-ketoesters. The developed method is simple, mild, and general route for the preparation of diversely functionalized 2-aminothiazoles in good to moderate yields from readily available starting materials.