302356-98-5Relevant articles and documents
Enantiospecific total synthesis of the enantiomer of the indole alkaloid affinisine
Liu,Wang,Xu,Ma,Cook
, p. 6299 - 6303 (2007/10/03)
The enantiomer of affinisine has been synthesized (from L-tryptophan) with 100% diastereoselectivity via the asymmetric Pictet-Spengler reaction coupled with a Pd°(enolate mediated) coupling process. This enantiomer has also been converted into a key inte
PICTET-SPENGLER REACTIONS IN APROTIC MEDIA. Nb-BENZYL PROMOTED RETENTION OF OPTICAL ACTIVITY IN THE SYNTHESIS OF AN INDOLO SUBSTITUTED AZABICYCLONONANE, A KEY TEMPLATE FOR THE SYNTHESIS OF MACROLINE ALKALOIDS.
Zhang, Lin-hua,Cook, James M.
, p. 2795 - 2802 (2007/10/02)
The Nb-benzyl group (see 7) has been employed in the Pictet-Spengler reaction in refluxing benzene to provide complete retention of optical activity in this process.The tetrahydro-β-carbolines 3b (trans) and 4b (cis) were independently converte