302600-49-3

Basic information

• Product Name: 2-(3-tert-butoxycarbonylamino-propionyl)-3-isobutyl-succinic acid 1-tert-butyl ester 4-methyl ester
• Synonyms: 2-(3-tert-butoxycarbonylamino-propionyl)-3-isobutyl-succinic acid 1-tert-butyl ester 4-methyl ester
• CAS NO: 302600-49-3
• Molecular Weight: 415.527
• Mol File: 302600-49-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(3-tert-butoxycarbonylamino-propionyl)-3-isobutyl-succinic acid 1-tert-butyl ester 4-methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-tert-butoxycarbonylamino-propionyl)-3-isobutyl-succinic acid 1-tert-butyl ester 4-methyl ester(302600-49-3)
• EPA Substance Registry System: 2-(3-tert-butoxycarbonylamino-propionyl)-3-isobutyl-succinic acid 1-tert-butyl ester 4-methyl ester(302600-49-3)

Safety Data

• Hazardous Substances Data: 302600-49-3(Hazardous Substances Data)

Upstream product

• 20312-37-2 (R)-2-hydroxy-4-methylpentanoic acid 

Downstream Products

• 302600-52-8 (R)-6-tert-Butoxycarbonylamino-2-isobutyl-4-oxo-hexanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-2-(4-methoxy-phenyl)-1-(2-trimethylsilanyl-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester 

Relevant articles and documents

Synthesis of stable analogs in blood and conformational analysis of arenastatin A, a potent cytotoxic spongean depsipeptide

In order to produce stable analogs in blood of arenastatin A, a potent cytotoxic depsipeptide from the marine sponge Dysidea arenaria, we synthesized four analogs in which the 15-20 ester linkage was modified. Among them, the carba analog and 20-deoxo analog showed stability in serum. The conformation of arenastatin A and its three analogs were analyzed by distance-restrained molecular dynamic calculation to elucidate a three-dimensional stereostructure contributing to the extremely potent cytotoxicity of arenastatin A.