3027-05-2

Basic information

• Product Name: N,N'-DIACETYLGLYCINE ANHYDRIDE
• Synonyms: N,N'-DIACETYLGLYCINE ANHYDRIDE;1,4-DIACETYL-PIPERAZINE-2,5-DIONE;1,4-DIACETYLTETRAHYDRO-2,5-PYRAZINEDIONE;1,4-DIACETYL-2,5-DIKETOPIPERAZINE;1,4-DIACETYL-2,5-DIOXOPIPERAZINE;1,4-DIACETYL-2,5-PIPERAZINEDIONE;1,4-Diacetyl-2,5-diketopiperazine 1,4-Diacetyl-2,5-dioxopiperazine 1,4-Diacetyl-2,5-piperazinedione;N,N′-Diacetyl-2,5-dioxopiperazine
• CAS NO: 3027-05-2
• Molecular Formula: C₈H₁₀N₂O₄
• Molecular Weight: 198.18
• Mol File: 3027-05-2.mol
• Article Data: 29

Chemical Properties

• Melting Point: 99-100°C
• Boiling Point: 424.4 °C at 760 mmHg
• Flash Point: 216.6 °C
• Appearance: /
• Density: 1.375 g/cm³
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: -1.74±0.20(Predicted)
• BRN: 188115
• CAS DataBase Reference: N,N'-DIACETYLGLYCINE ANHYDRIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N,N'-DIACETYLGLYCINE ANHYDRIDE(3027-05-2)
• EPA Substance Registry System: N,N'-DIACETYLGLYCINE ANHYDRIDE(3027-05-2)

Safety Data

• Hazard Codes: Xn
• Statements: 36/37/38-43-36/38-22
• Safety Statements: 26-36/37/39-36/37
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 3027-05-2(Hazardous Substances Data)

Usage

General Description

N,N'-Diacetylglycine anhydride is a chemical compound with the formula C8H10N2O5. It is a derivative of the amino acid glycine and is used as a reagent in organic synthesis. The compound is a white solid that is soluble in organic solvents. It is commonly used as an acetylation reagent in the production of pharmaceuticals and other organic compounds. N,N'-Diacetylglycine anhydride is also utilized in the preparation of peptide reagents and as a building block in the synthesis of complex organic molecules. It is important to handle this chemical with care and to follow proper safety precautions when working with it in the laboratory.

Upstream product

• 106-57-0 Glycine anhydride 
• 75-36-5 acetyl chloride 
• 292638-85-8 acrylic acid methyl ester 
• 153074-39-6 1,4-Diacetyl-3-bromopiperazine-2,5-dione 
• 109-92-2 ethyl vinyl ether 
• 107-13-1 acrylonitrile 
• 5535-48-8 PVS 
• 108-24-7 acetic anhydride 

Downstream Products

• 249620-64-2 (3Z,6Z)-3,6-bis(3,4-didodecyloxybenzylidene)piperazine-2,5-dione 
• 106-57-0 Glycine anhydride 
• 543-24-8 N-acetylglycine 

Relevant articles and documents

A highly substituted pyrazinophane generated from a quinoidal system: Via a cascade reaction

The generation of a highly-substituted [2.2](2,5)pyrazinophane via a cascade reaction is presented. The pyrazinophane product is formed via the dimerization of a member of the para-azaquinodimethane (p-AQM) family of conjugated quinoidal compounds - reactivity that sheds light on the nature of stability in p-AQMs. Additionally, the electronic and structural nature of this highly-strained ring system are characterized.

Phenotype-Guided Natural Products Discovery Using Cytological Profiling

Phenotype-guided natural products discovery is emerging as a useful new discovery tool that addresses challenges in early, unbiased natural product biological annotation. These high-content approaches yield screening results that report directly on the im

Chiral 1,2,3-Triazolium Salt Catalyzed Asymmetric Mono- and Dialkylation of 2,5-Diketopiperazines with the Construction of Tetrasubstituted Carbon Centers

Novel asymmetric mono- and dialkylation reactions of α-substituted 2,5-diketopiperazines catalyzed by new chiral spirocyclic-amide-derived triazolium organocatalysts have been developed, resulting in a range of enantioenriched 2,5-diketopiperazine derivatives containing one or two tetrasubstituted carbon stereocenters. The reactions feature high yields (up to 98%), and excellent cis-diastereo- and enantioselectivities (up to >20:1 dr, >99 % ee), and they provide a new asymmetric synthetic approach to important functionalized 2,5-diketopiperazine skeletons. Furthermore, a possible reaction mechanism was proposed based on both control experiments and extensive DFT calculations.

One pot synthesis of N-monoalkylated plinabulin derivatives via multicomponent protocol and their application as anticancer agents

A chemical library of seventeen N-monoalkylated plinabulin derivatives was designed and synthesized in one pot with high atom economy, good yield and operational simplicity in site selective manner with Z-configuration at 3,6-positions (3Z,6Z) which have

The synthesis and biological activity of the 3-ferrocenylpropenamides derived from 5(4H)-oxazolones

We described a synthesis of new 3-ferrocenylpropenamides prepared by oxazolone-ring opening reaction with various primary and secondary amines. The antiproliferative activities of the obtained compounds were screened on human tumor cell lines (HCT116, SW6