30286-75-0 Usage
Description
Oxitropium bromide is an analog of the anticholinergics methscopolamine bromide
and ipratropium bromide, useful in the treatment of bronchial asthma. Cited
advantages include a long duration of action and lack of cardiovascular effects.
Chemical Properties
White or almost white, crystalline powder.
Originator
Boehringer Ingelheim (W. Germany)
Uses
Different sources of media describe the Uses of 30286-75-0 differently. You can refer to the following data:
1. Anticholinergic; treatment of reversible airways obstruction.
2. Oxitropium Bromide is an anticholinergic agent.
Manufacturing Process
14.5 g (0.05 mol) of (-)-norscopolamine and 5.4 g (0.05 mol) of ethyl bromide were dissolved in 300 cc of acetonitrile, 5.3 g (0.05 mol) of anhydrous sodium carbonate were suspended in the solution, and the suspension was heated at the boiling point for 10 hours. After a boiling time of 2.5 and 5 hours, respectively, the supply of ethyl bromide and sodium carbonate in the reaction mixture was replenished by adding each time 5.4 g (0.05 mol) of ethyl bromide and 5.3 g (0.05 mol) of anhydrous sodium carbonate. At the end of 10 hours of boiling, the inorganic sodium salts which had separated out were separated by vacuum filtration, the filter cake was washed with acetonitrile, and the acetonitrile was distilled out of the filtrate. The distillation residue was dissolved in ether, the solution was extracted with a small amount of water and then dried, and the ether was distilled off, yielding raw (-)-N-ethylnorscopolamine.
7.0 g (0.022 mol) of (-)-N-ethylnorscopolamine were dissolved in acetonitrile, 10.4 g (0.11 mol) of methyl bromide were added to the solution, and the mixture was allowed to stand at room temperature. The crystalline precipitate formed thereby was collected and recrystallized from acetonitrile.8.9 g (97.8% of theory) of white crystalline (-)-N-ethylnorscopolamine methobromide, melting point 203°C to 204°C (decomposition), were obtained.
Brand name
Oxivent (Boehringer Ingelheim);TERSIGAT.
Therapeutic Function
Anticholinergic bronchodilator
Safety Profile
Poison by intravenous route. Moderately toxic by ingestion and subcutaneous routes. An anticholinergic bronchodilator. When heated to decomposition it emits very toxic fumes of NOx and Brí.
Check Digit Verification of cas no
The CAS Registry Mumber 30286-75-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,0,2,8 and 6 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 30286-75:
(7*3)+(6*0)+(5*2)+(4*8)+(3*6)+(2*7)+(1*5)=100
100 % 10 = 0
So 30286-75-0 is a valid CAS Registry Number.
InChI:InChI=1/C19H26NO4.BrH/c1-3-20(2)15-9-13(10-16(20)18-17(15)24-18)23-19(22)14(11-21)12-7-5-4-6-8-12;/h4-8,13-18,21H,3,9-11H2,1-2H3;1H/q+1;/p-1/t13?,14-,15-,16-,17-,18+,20?;/m1./s1
30286-75-0Relevant articles and documents
Pharmaceutical composition using a mixture of propellant gases for a metered dose inhaler
-
, (2008/06/13)
New advantageous propellent gas mixtures contain two or more components, at least one of which is a partially fluorinated lower alkane, and may be used in pharmaceutical preparations.
The synthesis of anticholinergically active N-alkylnorscopolamines and their quaternary salts with particular consideration of the bronchospasmolytic compound (-)-N-ethylnorscopolamine methobromide (Ba 253 BR)
Banholzer,Pook
, p. 217 - 228 (2007/10/02)
The synthesis of anticholinergic N-alkylnorscopolamines and their quaternary salts, especially the synthesis of (-)-N-ethylnorscopolamine methobromide (Ba 253 BR), is reported. (-)-N-Ethylnorscopolamine methobromide differs from the stereoisomeric (-)-N-ethylscopolammonium bromide not only by its physico-chemical, but also by its pharmacological properties. (-)-N-Ethylnorscopolamine methobromide represents an anticholinergic bronchodilator with long duration of action.
