302901-22-0

Basic information

• Product Name: 1-NAPHTHALENECARBOXAMIDE, N-(2-METHYLPHENYL)-
• Synonyms: 1-NAPHTHALENECARBOXAMIDE,N-(2-METHYLPHENYL)-
• CAS NO: 302901-22-0
• Molecular Formula: C18H15NO
• Molecular Weight: 261.323
• Mol File: 302901-22-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-NAPHTHALENECARBOXAMIDE, N-(2-METHYLPHENYL)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-NAPHTHALENECARBOXAMIDE, N-(2-METHYLPHENYL)-(302901-22-0)
• EPA Substance Registry System: 1-NAPHTHALENECARBOXAMIDE, N-(2-METHYLPHENYL)-(302901-22-0)

Safety Data

• Hazardous Substances Data: 302901-22-0(Hazardous Substances Data)

Usage

Type of compound

Naphthalenecarboxamide derivative

Usage

Production of coatings, adhesives, sealants, and elastomers; intermediate for synthesis of pharmaceuticals and agrochemicals

Biological activities

Anti-inflammatory and anti-cancer properties (requires further research)

Importance

Versatile and widely used in industrial and research applications

Upstream product

• 201230-82-2 carbon monoxide 
• 90-14-2 1-Iodonaphthalene 
• 95-53-4 o-toluidine 
• 86-55-5 1-naphthalenecarboxylic acid 
• 879-18-5 naphthalene-1-carbonic acid chloride 

Relevant articles and documents

Palladium-Catalyzed Annulation of Arylbenzamides with Diaryliodonium Salts

By using diaryliodonium salts, a cylization has been accomplished in the synthesis of N-aryl phenanthridinone derivatives via a cascade of ortho-arylation and Csp2-N bond formation in the presence of palladium catalyst. The reaction exhibits a broad compatibility of readily available N-arylnaphthamides. (Figure presented.).

Highly efficient aminocarbonylation of iodoarenes at atmospheric pressure catalyzed by a robust acenaphthoimidazolyidene allylic palladium complex

A robust allylic palladium-NHC complex was developed and exhibited extremely high catalytic activity toward aminocarbonylation of various (hetero)aryl iodides under atmospheric carbon monoxide pressure, in which a broad range of secondary and primary amines were well tolerated. In addition, the concise synthesis of an anticancer drug tamibarotene was accomplished even in a gram scale, further highlighting the practical applicability of the protocol.