30299-28-6

Basic information

• Product Name: 2-(4-{1-[4-(1-Ethoxycarbonyl-1-methyl-propoxy)-phenyl]-cyclohexyl}-phenoxy)-2-methyl-butyric acid ethyl ester
• Synonyms: 2-(4-{1-[4-(1-Ethoxycarbonyl-1-methyl-propoxy)-phenyl]-cyclohexyl}-phenoxy)-2-methyl-butyric acid ethyl ester
• CAS NO: 30299-28-6
• Molecular Weight: 524.698
• Mol File: 30299-28-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(4-{1-[4-(1-Ethoxycarbonyl-1-methyl-propoxy)-phenyl]-cyclohexyl}-phenoxy)-2-methyl-butyric acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-{1-[4-(1-Ethoxycarbonyl-1-methyl-propoxy)-phenyl]-cyclohexyl}-phenoxy)-2-methyl-butyric acid ethyl ester(30299-28-6)
• EPA Substance Registry System: 2-(4-{1-[4-(1-Ethoxycarbonyl-1-methyl-propoxy)-phenyl]-cyclohexyl}-phenoxy)-2-methyl-butyric acid ethyl ester(30299-28-6)

Safety Data

• Hazardous Substances Data: 30299-28-6(Hazardous Substances Data)

Upstream product

• 108-94-1 cyclohexanone 
• 108-95-2 phenol 
• 843-55-0 1,1-bis(p-hydroxyphenyl)cyclohexane 
• 5398-71-0 2-bromo-2-ethyl-2-methyl acetic acid ethyl ester 
• 116-53-0 2-Methylbutanoic acid 

Downstream Products

• 30299-08-2 clinofibrate 

Relevant articles and documents

Method for preparing high-purity kerley Bette

The invention relates to a preparation method of high-purity clinofibrate, the field of preparation of pharmaceutical compounds. The preparation method comprises the following steps: reacting cyclohexanone and phenol in concentrated hydrochloric acid and glacial acetic acid in a volume ratio of 3:1-7:1 to obtain an intermediate I crude product, decolorizing with a single solvent, and cooling to crystallize to obtain an intermediate I; reacting 2-methylbutyric acid with liquid bromine in phosphorus trichloride, reacting with anhydrous alcohol, extracting, and carrying out vacuum distillation to obtain an intermediate II; reacting the intermediate I and the intermediate II under solventless conditions to obtain an intermediate III; and hydrolyzing the intermediate III and sodium hydroxide, extracting, crystallizing to obtain a clinofibrate crude product; and recrystallizing with an anhydrous solvent to obtain the clinofibrate. The material proportion is adjusted to shorten the production operation period; the invention has the advantages of low energy consumption and low solvent consumption; and the obtained product has the advantages of uniform crystal grains, high purity and low cost.