303752-38-7

Basic information

• Product Name: 3-[(TERT-BUTOXYCARBONYL)AMINO]BICYCLO[1.1.1]PENTANE-1-CARBOXYLIC ACID
• Synonyms: 3-[(TERT-BUTOXYCARBONYL)AMINO]BICYCLO[1.1.1]PENTANE-1-CARBOXYLIC ACID;3-(Boc-aMino)-bicyclo[1.1.1]pentane-1-carboxylic acid;3-Aminobicyclo[1.1.1]pentane-1-carboxylicacid,N-BOCprotected;Bicyclo[1.1.1]pentane-1-carboxylic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-
• CAS NO: 303752-38-7
• Molecular Formula: C₁₁H₁₇NO₄
• Molecular Weight: 227.25698
• Mol File: 303752-38-7.mol
• Article Data: 12

Chemical Properties

• Melting Point: 172 °C (decomp)(Solv: ethyl ether (60-29-7))
• Boiling Point: 370.4±41.0 °C(Predicted)
• Appearance: /
• Density: 1.26±0.1 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.69±0.40(Predicted)
• CAS DataBase Reference: 3-[(TERT-BUTOXYCARBONYL)AMINO]BICYCLO[1.1.1]PENTANE-1-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[(TERT-BUTOXYCARBONYL)AMINO]BICYCLO[1.1.1]PENTANE-1-CARBOXYLIC ACID(303752-38-7)
• EPA Substance Registry System: 3-[(TERT-BUTOXYCARBONYL)AMINO]BICYCLO[1.1.1]PENTANE-1-CARBOXYLIC ACID(303752-38-7)

Safety Data

• Hazardous Substances Data: 303752-38-7(Hazardous Substances Data)

Usage

Uses

3-(Boc-amino)bicyclo[1.1.1]pentane-1-carboxylic Acid is used as an intermediate for preparation of heteroaryldihydropyrimidine derivatives which are applied for treatment of hepatitis B infections

Upstream product

• 676371-64-5 3-((tert-butoxycarbonyl)amino)bicyclo[1.1.1]pentane-1-carboxylic acid methyl ester 
• 83249-10-9 3‐(methoxycarbonyl)bicyclo[1.1.1]pentane‐1‐carboxylic acid 
• 83249-09-6 methyl 3-phenylbicyclo<1.1.1>pentane-1-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1172097-47-0 3-aminobicyclo[1.1.1]pentane-1-carboxylic acid hydrochloride 
• 1172097-47-0 3-aminobicyclo[1.1.1]pentane-1-carboxylic acid hydrochloride 
• 115913-32-1 dimethyl bicyclo<1.1.1>pentane-1,3-dicarboxylate 
• 115913-30-9 1,1′-(bicyclo[1.1.1]pentane-1,3-diyl)bis(ethan-1-one) 
• 56842-95-6 bicyclo<1.1.1>pentane-1,3-dicarboxylic acid 

Downstream Products

• 676371-75-8 Fmoc-bicyclo[1.1.1]pentane-L-Tyr(O-t-Bu)-L-Leu-OMe 
• 676371-64-5 3-((tert-butoxycarbonyl)amino)bicyclo[1.1.1]pentane-1-carboxylic acid methyl ester 
• 1935125-14-6 3-(((benzyloxy)carbonyl)amino)bicyclo[1.1.1]pentane-1-carboxylic acid 
• 1172097-47-0 3-aminobicyclo[1.1.1]pentane-1-carboxylic acid hydrochloride 
• 1638771-06-8 tert-butyl (3-formyl bicyclo[1.1.1]pentan-1-yl)carbamate 
• 1638767-25-5 tert-butyl N-(1-amino-3-bicyclo[1.1.1]pentanyl)carbamate 
• 1638765-26-0 (3-(hydroxymethyl)bicyclo[1.1.1]pent-1-yl)carbamic acid tert-butyl ester 

Relevant articles and documents

Large-Scale Synthesis and Modifications of Bicyclo[1.1.1]pentane-1,3-dicarboxylic Acid (BCP)

In flow photochemical addition of propellane to diacetyl allowed construction of the bicyclo[1.1.1]pentane (BCP) core in a 1 kg scale within 1 day. Haloform reaction of the formed diketone in batch afforded bicyclo[1.1.1]pentane-1,3-dicarboxylic acid in a

HETEROARYLDIHYDROPYRIMIDINE DERIVATIVES AND METHODS OF TREATING HEPATITIS B INFECTIONS

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COMPOUNDS, COMPOSITIONS AND METHODS

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