30379-55-6

Basic information

• Product Name: Benzyloxyacetic acid
• Synonyms: PHENYLMETHOXY ACETIC ACID;RARECHEM AL BE 0628;BENZYLOXYACETIC ACID;ACETIC ACID, (PHENYLMETHOXY)-;benzyloxy acctic acid;2-(benzyloxy)acetic acid;Acetic acid, 2-(phenylMethoxy)-;Benzyloxyacetic acid 95%
• CAS NO: 30379-55-6
• Molecular Formula: C₉H₁₀O₃
• Molecular Weight: 166.17
• Product Categories: C9;Carbonyl Compounds;Carboxylic Acids;Building Blocks/Intermediates;NULL
• Mol File: 30379-55-6.mol
• Article Data: 48

Chemical Properties

• Melting Point: 80-81 °C
• Boiling Point: 137-139 °C0.6 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 1.162 g/mL at 25 °C(lit.)
• Vapor Pressure: 9.33E-05mmHg at 25°C
• Refractive Index: n20/D 1.526(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.52±0.10(Predicted)
• CAS DataBase Reference: Benzyloxyacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: Benzyloxyacetic acid(30379-55-6)
• EPA Substance Registry System: Benzyloxyacetic acid(30379-55-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 30379-55-6(Hazardous Substances Data)

Usage

Chemical Properties

Colorless liquid

Uses

Different sources of media describe the Uses of 30379-55-6 differently. You can refer to the following data:
1. It is a compound for proteomics research use. It may be used for following synthesis mixed benzyloxyacetic pivalic anhydride, chiral glycolates, 1,2:4,5-di-O-isopropylidene-β-D-fructopyranos-3-yl benzyloxyacetate, via esterification, tetra aqua(1,10-phenanthroline-[κ]2N,N?)magnesium(II) bis[(2,4-dichlorophenyl)acetate], as ligand in the preparation of diaquabis(benzyloxyacetato)copper(II) complex.
2. Benzyloxyacetic acid may be used for the following syntheses:mixed benzyloxyacetic pivalic anhydridechiral glycolates, 1,2:4,5-di-O-isopropylidene-β-D-fructopyranos-3-yl benzyloxyacetate, via esterificationtetraaqua(1,10-phenanthroline-[κ]2N,N′)magnesium(II) bis[(2,4-dichlorophenyl)acetate]as ligand in the preparation of diaquabis(benzyloxyacetato)copper(II) complex

General Description

In vitro activities of phenoxy and benzyloxyacetic acid derivatives as antisickling agents has been investigated by the application of quantitative structure activity relationship (QSAR) of Hansch-type.

InChI:InChI=1/C9H10O3/c10-9(11)7-12-6-8-4-2-1-3-5-8/h1-5H,6-7H2,(H,10,11)

Upstream product

• 100-51-6 benzyl alcohol 
• 30379-54-5 benzyloxyacetate de benzyle 
• 105-39-5 chloroacetic acid ethyl ester 
• 79-08-3 bromoacetic acid 
• 20194-18-7 sodium phenyl-methanolate 
• 31600-43-8 methyl 2-(benzyloxy)acetate 
• 124-38-9 carbon dioxide 
• 66222-28-4 (benzyloxymethyl)tributylstannane 
• 79-11-8 chloroacetic acid 
• 13071-59-5 3-benzyloxypropan-1,2-diol 
• 622-08-2 2-Benzyloxyethanol 
• 14690-00-7 2-O-benzylglycerol 
• 51164-00-2 4-Benzyloxymethyl-2-phenyl-[1,3]dioxolane 
• 68728-34-7 5-benzyloxy-2-phenyl-1,3-dioxane 

Downstream Products

• 97416-41-6 trimethylsilyl 2-(benzyloxy)acetate 
• 70258-22-9 1-Benzyloxy-9b-phenyl-1,4,5,9b-tetrahydro-azeto[2,1-a]isoquinolin-2-one 
• 81017-16-5 3-Benzyloxy-4-(4-chloro-phenyl)-1-(4-methoxy-phenyl)-azetidin-2-one 
• 61458-01-3 3-benzyloxy-4-(4-methoxy-phenyl)-1-p-tolyl-azetidin-2-one 
• 154710-30-2 Benzyloxy-acetic acid 2-bromo-3-methyl-cyclohex-2-enyl ester 
• 66922-43-8 formaldehyde benzyl t-butyl acetal 
• 88920-28-9 benzyloxymethyl benzyloxyacetate 
• 112497-09-3 1-Benzyloxy-3-((R)-toluene-4-sulfinyl)-propan-2-one 
• 61458-01-3 (3S,4R)-3-Benzyloxy-4-(4-methoxy-phenyl)-1-p-tolyl-azetidin-2-one 
• 81017-15-4 3-Benzyloxy-4-(4-benzyloxy-phenyl)-1-(4-chloro-phenyl)-azetidin-2-one 
• 115140-93-7 Benzyloxy-acetic acid (R)-1-{(3aS,4S,7S,7aR)-4-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-7-ylmethyl}-but-2-ynyl ester 
• 144446-51-5 (1S,2R,5R)-1-(2-Benzyloxy-acetoxy)-2-[(E)-3-(tert-butyl-dimethyl-silanyloxy)-propenyl]-4-(tert-butyl-diphenyl-silanyloxymethyl)-5-methyl-cyclohex-3-enecarboxylic acid methyl ester 
• 144446-56-0 (1S,2R,5R)-1-(2-Benzyloxy-acetoxy)-2-[(E)-7-(tert-butyl-dimethyl-silanyloxy)-hept-1-enyl]-4-(tert-butyl-diphenyl-silanyloxymethyl)-5-methyl-cyclohex-3-enecarboxylic acid methyl ester 
• 142611-72-1 (3S)-(Z)-1-(Dimethylphenylsilyl)-1-buten-3-yl (benzyloxy)acetate 

Relevant articles and documents

On the electron withdrawing nature of ethers in glycosylation chemistry

The present paper is a commentary on the electronic effects that protecting groups exert on glycosylation chemistry. Specifically, its purpose is to rectify the misguided use of the term electron donating benzyl groups, which hardly makes sense in the context of protecting groups on alcohols in saturated systems such as carbohydrates. It is argued that benzyl ethers (OBn) should rightfully be referred to as being inductively electron withdrawing, even if they are less so than benzoyl esters (OBz).

Nickel-Catalyzed Cyanation of Aryl Thioethers

A nickel-catalyzed cyanation of aryl thioethers using Zn(CN)2 as a cyanide source has been developed to access functionalized aryl nitriles. The ligand dcype (1,2-bis(dicyclohexylphosphino)ethane) in combination with the base KOAc (potassium acetate) is essential for achieving this transformation efficiently. This reaction involves both a C-S bond activation and a C-C bond formation. The scalability, low catalyst and reagents loadings, and high functional group tolerance have enabled both late-stage derivatization and polymer recycling, demonstrating the reaction's utility across organic chemistry.

Oxidation of Primary Alcohols and Aldehydes to Carboxylic Acids via Hydrogen Atom Transfer

The oxidation of primary alcohols and aldehydes to the corresponding carboxylic acids is a fundamental reaction in organic synthesis. In this paper, we report a new chemoselective process for the oxidation of primary alcohols and aldehydes. This metal-free reaction features a new oxidant, an easy to handle procedure, high isolated yields, and good to excellent functional group tolerance even in the presence of vulnerable secondary alcohols and tert-butanesulfinamides.