303957-69-9 Usage
Description
Reutericyclin is a cyclic peptide antibiotic produced by certain strains of Lactobacillus reuteri bacteria. It is characterized by its strong anti-microbial activity against various pathogenic bacteria, such as Staphylococcus aureus, Streptococcus pyogenes, and Clostridium difficile. reutericyclin works by disrupting bacterial cell membranes and inhibiting protein synthesis, making it a promising natural compound in the field of antibiotic research and development.
Uses
Used in Pharmaceutical Industry:
Reutericyclin is used as a therapeutic agent for the treatment of bacterial infections. Its effectiveness in inhibiting the growth of pathogenic bacteria, such as Staphylococcus aureus, Streptococcus pyogenes, and Clostridium difficile, makes it a valuable asset in combating antibiotic-resistant strains and improving patient outcomes.
Used in Food Preservation Industry:
Reutericyclin is used as a natural preservative to extend the shelf life of food products. Its strong anti-microbial properties help to inhibit the growth of spoilage-causing bacteria, ensuring the safety and quality of food items while reducing the reliance on synthetic preservatives.
Check Digit Verification of cas no
The CAS Registry Mumber 303957-69-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,0,3,9,5 and 7 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 303957-69:
(8*3)+(7*0)+(6*3)+(5*9)+(4*5)+(3*7)+(2*6)+(1*9)=149
149 % 10 = 9
So 303957-69-9 is a valid CAS Registry Number.
303957-69-9Relevant articles and documents
Synthesis of the antibiotic (R)-reutericyclin via Dieckmann condensation
Boehme, Roswitha,Jung, Guenther,Breitmaier, Eberhard
, p. 2837 - 2841 (2005)
(R)-Reutericyclin ((R)-1), a bactericidal, amphiphilic natural product with a trisubstituted tetramic acid moiety, was prepared in four steps from D-leucine in anoverall yieldof 24%. The chiral heterocyclic portion of 1 was synthesized by Dieckmann cyclization of ethyl N-(acetoacetyl)leucinate (7), and the resulting pyrrole derivative 8 was N-acylated with (E)-dec-2-enoyl chloride in the presence of BuLi at-70° (Scheme2). This new procedure is straightforward and allows the synthesis of both antipodes of reutericyclin in anenantiomeric excess (ee) of ca. 80%.