30411-81-5Relevant articles and documents
Sodium dichloroiodate promoted C-C bond cleavage: An efficient synthesis of 1,3-Benzazoles via condensation of o -amino/mercaptan/hydroxyanilines with β -diketones
Bhagat, Saket B,Ghodse, Shrikant M,Telvekar, Vikas N
, (2018/02/09)
An efficient aqueous sodium dichloroiodate (NaICl 2) mediated protocol is developed for the synthesis of benzofused azoles by the cyclization of 2-amino anilines/thiophenols/phenols with β-diketone compounds. The reactions gave moderate to good yield of the corresponding 2-substituted benzimidazoles/benzothiazoles/benzoxazoles under mild conditions. This tandem process involved a C-C bond cleavage and C-N bond formation. Graphical Abstract?: SYNOPSIS A facile and single protocol for the synthesis of three versatile 1,3-benzazoles viz 2-substituted 1H-benzimidazoles, benzoxazoles and benzothiazoles from readily available starting materials, 1,3-diketones and corresponding o-amino anilines/thiophenols/phenols, by aqueous sodium dichloroiodate (NaICl 2) mediated C—C bond cleavage has been developed. The reaction provides a rapid access to these 1, 3-benzazoles in good yields, thus speeding up the drug discovery process.[Figure not available: see fulltext.].
Method for preparing benzimidazole compound through supported bimetallic catalyst at room temperature
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Paragraph 0090, (2017/07/21)
The invention belongs to the technical field of photochemistry organic synthesis, and particularly relates to a method for preparing a benzimidazole compound through a supported bimetallic catalyst at room temperature .The preparation method of the benzimidazole compound comprises the steps that o-phenylenediamine and reactant alcohol are used as initial reactants, a photocatalyst is used as a supported bimetallic nanoparticles, in an organic solvent and under the stirring condition and irradiation of ultraviolet light or visible light or sunlight, the o-phenylenediamine and the reactant alcohol are directly subjected to photocatalysis through light source irradiation to be converted into benzimidazole and a derivative thereof .According to the method, reaction conditions are mild, high-temperature reaction conditions are not needed, the reaction speed at room temperature is high, and the selectivity of the target product benzimidazole is 95% or above .
A rapid access to novel and known benzimidazole derivatives using silica chloride as a reusable catalyst
Karami, Bahador,Ghashghaee, Vahideh,Khodabakhshi, Saeed
experimental part, p. 959 - 964 (2012/05/31)
A new application of silica chloride as an easily available and reusable solid acid catalyst for the synthesis of benzimidazole and its derivatives through the condensation of o-phenylenediamines and orthoesters under thermal and solvent-free conditions is described. This novel and eco-friendly method is very cheap and has many advantages including excellent yields, short reaction time, and simple work-up procedure. Copyright