30425-47-9

Basic information

• Product Name: 1-(4-methoxyphenyl)pyrrolidin-2-one
• Synonyms: 1-(4-methoxyphenyl)pyrrolidin-2-one;2-pyrrolidinone, 1-(4-methoxyphenyl)-;1-(4-methoxyphenyl)-2-pyrrolidone;3-(4-methoxyphenyl)pyrrolidin-2-one
• CAS NO: 30425-47-9
• Molecular Formula: C₁₁H₁₃NO₂
• Molecular Weight: 191.22642
• EINECS: 250-191-1
• Mol File: 30425-47-9.mol
• Article Data: 57

Chemical Properties

• Boiling Point: 414.7°Cat760mmHg
• Flash Point: 204.6°C
• Appearance: /
• Density: 1.162g/cm³
• Vapor Pressure: 4.35E-07mmHg at 25°C
• Refractive Index: 1.561
• CAS DataBase Reference: 1-(4-methoxyphenyl)pyrrolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-methoxyphenyl)pyrrolidin-2-one(30425-47-9)
• EPA Substance Registry System: 1-(4-methoxyphenyl)pyrrolidin-2-one(30425-47-9)

Safety Data

• Hazardous Substances Data: 30425-47-9(Hazardous Substances Data)

Usage

Description

1-(4-methoxyphenyl)pyrrolidin-2-one is an organic compound that serves as a valuable synthetic intermediate in the pharmaceutical industry. It is characterized by its unique molecular structure, which features a pyrrolidinone ring with a 4-methoxyphenyl group attached. This structure endows the compound with specific properties that make it useful in the development of various pharmaceutical agents.

Uses

Used in Pharmaceutical Industry:
1-(4-methoxyphenyl)pyrrolidin-2-one is used as a synthetic intermediate for the development of pharmaceutical compounds. Its unique molecular structure allows it to be a key component in the synthesis of various drugs, contributing to their therapeutic effects.
Used in the Synthesis of Clanobutin (C558000):
1-(4-methoxyphenyl)pyrrolidin-2-one is used as a synthetic intermediate for the production of Clanobutin (C558000), a compound that inhibits gluconeogenesis in isolated perfused rat livers. This inhibition helps regulate glucose metabolism and can be beneficial for the treatment of conditions related to glucose imbalance, such as diabetes.
Used as a Choleretic Agent:
1-(4-methoxyphenyl)pyrrolidin-2-one is used as a choleretic agent, which means it promotes the flow of bile from the liver to the small intestine. This can help improve digestion and absorption of fats and fat-soluble vitamins, as well as support the elimination of waste products from the body.
Used as a Digestion-Stimulating Agent for Animals:
In the veterinary field, 1-(4-methoxyphenyl)pyrrolidin-2-one is used as a digestion-stimulating agent for animals. By enhancing the digestive process, it can help improve the overall health and well-being of animals, particularly those with digestive issues or those that require additional support for optimal digestion.

InChI:InChI=1/C11H13NO2/c1-14-10-6-4-9(5-7-10)12-8-2-3-11(12)13/h4-7H,2-3,8H2,1H3

Upstream product

• 77-78-1 dimethyl sulfate 
• 7517-07-9 1-(4-hydroxyphenyl)pyrrolidin-2-one 
• 173345-91-0 N-(p-methoxyphenyl)-4-chlorobutyramide 
• 616-45-5 2-pyrrolidinon 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 623-12-1 4-chloromethoxybenzene 
• 68737-65-5 (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane 
• 5097-25-6 N-(4-methoxylphenyl)piperidine 
• 4641-57-0 1-phenylpyrrolidin-2-one 
• 67-56-1 methanol 
• 1003309-09-8 1-[4-(4,4,5,5-tetramethyl-[1 ,3,2]dioxaborolan-2-yl)phenyl]pyrrolidin-2-one 
• 110-63-4 Butane-1,4-diol 
• 104-94-9 4-methoxy-aniline 
• 773837-37-9 sodium cyanide 

Downstream Products

• 58973-30-1 1-(4-methoxyphenyl)pyrrolidine-2-thione 
• 208646-35-9 N-(4-methoxyphenyl)-5-aminopentan-2-one 
• 208646-48-4 ethyl (4-methoxyphenylamino)propyl ketone 
• 208646-36-0 N-(4-methoxyphenyl)-7-aminoheptan-4-one 
• 6497-50-3 3-ethyl-1-(4-fluoro-phenyl)-6-(4-methoxy-phenyl)-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one 
• 162142-21-4 4-acetyl-3-hydroxy-1-(4-methoxyphenyl)-2-oxo-1,2,5,6-tetrahydropyridine 
• 162142-22-5 3-hydroxy-1-(4-methoxyphenyl)-2-oxo-4-propionyl-1,2,5,6-tetrahydropyridine 
• 179171-55-2 3-methoxy-1-(4-methoxyphenyl)-2-oxo-4-propionyl-1,2,5,6-tetrahydropyridine 
• 162142-23-6 4-butyryl-3-hydroxy-1-(4-methoxyphenyl)-2-oxo-1,2,5,6-tetrahydropyridine 
• 162141-77-7 1-Cyclopentyl-3-ethyl-6-(4-methoxy-phenyl)-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one 
• 1263220-14-9 C₂₀H₂₂N₂O₃ 
• 883794-31-8 C₁₁H₁₂BrNO₂ 
• 1325188-76-8 1-(3-((3R,5S)-3,5-dimethylpiperazin-1-yl)-4-methoxyphenyl)pyrrolidin-2-one 

Relevant articles and documents

Synthetic method of N - aryl substituted lactam compound

The invention discloses a method. NSynthesis method of - aryl substituted lactam compound, and synthesis method thereof is promoted by tertiary butyl hydroperoxide and-tert-butyl hydroperoxideNMulti-step series reaction synthesis - aryl substituted saturated cyclic amine compoundN- Aryl substituted lactam compounds are simple and convenient to operate. The method has the advantages of no transition metal catalysis, wide substrate application range and the like, and is suitable for industrial production.

Para-selective borylation of monosubstituted benzenes using a transient mediator

Herein, we conceptualized a transient mediator approach that has the capability of para-selective C-H functionalization of monosubstituted aromatics. This approach is enabled by in situ generation of a versatile sulfonium salt via highly electrophilic phenoxathiine or thianthrene dication intermediate which can be readily generated from its sulfoxide with trifluoromethanesulfonic anhydride. Preliminary mechanistic study implied that the remarkable para selectivity might be related to the incredible electrophilicity of thianthrene dication intermediate. The versatility of this approach was demonstrated via para-borylation of various monosubstituted simple aromatics combining the sulfonium salt formation with further photocatalyzed transformation.

Amidation of Aryl Chlorides Using a Microwave-Assisted, Copper-Catalyzed Concurrent Tandem Catalytic Methodology

A concurrent tandem catalytic (CTC) methodology has been developed for the amidation of aryl chlorides where the aryl chloride is first converted to an aryl iodide via halogen exchange and the aryl iodide is subsequently transformed into the aryl amide. A variety of aryl chlorides were converted to aryl amides in up to 85% isolated yield using 20 mol % CuI, 60 mol % N,N′-cyclohexane-1,2-diamine, 2.2 equiv of K2CO3, and 1.05-1.5 equiv of amide in acetonitrile at 200 °C after 0.75-1 h. The same copper/ligand system served as multifunctional catalyst for both steps of the concurrent catalytic process with iodide present in substoichiometric amounts. Mechanistic studies were consistent with CTC amidation occurring via a nonradical mechanism. Kinetic modeling was conducted to investigate the effect of competitive direct amidation of an aryl chloride or aryl bromide on the formation of product over time during a CTC amidation reaction.