3048-46-2

Basic information

• Product Name: Benzothiazole, 4-methoxy- (7CI,8CI,9CI)
• Synonyms: Benzothiazole, 4-methoxy- (7CI,8CI,9CI);Benzothiazole, 4-methoxy-;4-methoxy-Benzothiazole;4-methoxy-1,3-benzothiazole;4-methoxybenzo[d]thiazole
• CAS NO: 3048-46-2
• Molecular Formula: C₈H₇NOS
• Molecular Weight: 165.21228
• Product Categories: BENZOTHIAZOLE
• Mol File: 3048-46-2.mol
• Article Data: 11

Chemical Properties

• Melting Point: 103 °C
• Boiling Point: 274.42 °C at 760 mmHg
• Flash Point: 119.765 °C
• Appearance: /
• Density: 1.268 g/cm³
• Vapor Pressure: 0.009mmHg at 25°C
• Refractive Index: 1.646
• Storage Temp.: 2-8°C
• PKA: 1.00±0.10(Predicted)
• CAS DataBase Reference: Benzothiazole, 4-methoxy- (7CI,8CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzothiazole, 4-methoxy- (7CI,8CI,9CI)(3048-46-2)
• EPA Substance Registry System: Benzothiazole, 4-methoxy- (7CI,8CI,9CI)(3048-46-2)

Safety Data

• Hazardous Substances Data: 3048-46-2(Hazardous Substances Data)

Usage

General Description

4-methoxy-Benzothiazole (7CI,8CI,9CI) is a chemically synthesized compound that's based on benzothiazole, a type of heterocyclic compound. The addition of a methoxy group (-OCH3) on the benzothiazole base makes it different. This chemical compound is known for its diverse physical and chemical properties, which makes it applicable in various fields. It is frequently used in the manufacture of dyes, rubber accelerators and fungicides. The compound is also used in various chemical research and development processes. However, like other chemical compounds, handling must be done with utmost care as it may cause irritation to the eyes, skin, and respiratory tract.

InChI:InChI=1/C8H7NOS/c1-10-6-3-2-4-7-8(6)9-5-11-7/h2-5H,1H3

Upstream product

• 124-38-9 carbon dioxide 
• 73931-64-3 2-amino-3-methoxybenzenethiol 
• 90915-52-9 N-(4-methoxybenzo[d]thiazol-2-yl)acetamide 
• 5464-79-9 4-methoxy-1,3-benzothiazol-2-amine 
• 3507-48-0 4-methoxybenzo[d]thiazole-2-carboxylic acid 
• 1516-37-6 1-(2-methoxyphenyl)thiourea 
• 90-04-0 2-methoxy-phenylamine 

Downstream Products

• 7405-23-4 4-hydroxybenzothiazole 
• 73931-64-3 2-amino-3-methoxybenzenethiol 
• 67694-77-3 4-Oxiranylmethoxy-benzothiazole 
• 1312610-50-6 C₁₇H₁₃NO₂S 
• 1312610-51-7 C₄₁H₄₉N₅O₁₂S 
• 1312608-63-1 C₄₁H₄₉N₉O₆S 
• 1312610-85-7 C₄₃H₅₃N₅O₁₂S 
• 1312608-74-4 C₄₃H₅₃N₉O₆S 
• 1448856-32-3 2-(phenylthio)-4-methoxybenzo[d]thiazole 

Relevant articles and documents

Synthesis of benzothiazoles from 2-aminobenzenethiols in the presence of a reusable polythiazolium precatalyst under atmospheric pressure of carbon dioxide

Synthesis of benzothiazoles from 2-aminobenzenethiols and carbon dioxide was carried out using poly(3,4-dimethyl-5-vinylthiazolium) iodide as a precatalyst to in situ generation of NHCs by deprotonation. The reaction was successfully carried out under mild conditions (1 atm of CO2 and 60–70 °C) with a broad substrate scope and functional group tolerance. The precatalyst salt was recovered and reused for several times without any loss of activity.

IMIDAZOTHIADIAZOLE DERIVATIVES AS PROTEASE ACTIVATED RECEPTOR 4 (PAR4) INHIBITORS FOR TREATING PLATELET AGGREGATION

The present invention provides imidazothiadiazole compounds of Formula (I) wherein A, B, D, Rx, R1, R2, R3, X1, X2 and s are as defined herein, or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of platelet aggregation and thus can be used as medicaments.

Design, synthesis and activity of benzothiazole-based inhibitors of NO production in LPS-activated macrophages

Series of benzothiazoles were synthesized and evaluated their inhibitory activities for NO production in lipopolysaccharide-activated macrophages. The most potent compound was the indole-containing benzothiazole 3c with 4.18 μM of IC50. The mec