30481-54-0

Basic information

• Product Name: 2-AMINO-5-NITROBENZANILIDE
• Synonyms: 2-Amino-5-nitro-N-phenylbenzamide;2-AMINO-5-NITROBENZANILIDE
• CAS NO: 30481-54-0
• Molecular Formula: C₁₃H₁₁N₃O₃
• Molecular Weight: 257.24
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
• Mol File: 30481-54-0.mol
• Article Data: 5

Chemical Properties

• Melting Point: 202-204°C
• Boiling Point: 410.2 °C at 760 mmHg
• Flash Point: 201.9 °C
• Appearance: /
• Density: 1.41 g/cm³
• Vapor Pressure: 6.15E-07mmHg at 25°C
• Refractive Index: 1.714
• PKA: 12.25±0.70(Predicted)
• CAS DataBase Reference: 2-AMINO-5-NITROBENZANILIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-5-NITROBENZANILIDE(30481-54-0)
• EPA Substance Registry System: 2-AMINO-5-NITROBENZANILIDE(30481-54-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 30481-54-0(Hazardous Substances Data)

Usage

Description

2-Amino-5-nitrobenzanilide, a chemical compound with the molecular formula C13H11N3O3, is a yellow crystalline solid. It is recognized for its nitro and amino functional groups, which contribute to its versatility as a building block in the synthesis of various organic compounds. 2-AMINO-5-NITROBENZANILIDE is primarily utilized as an intermediate in the production of pharmaceuticals and dyes.

Uses

Used in Pharmaceutical Industry:
2-Amino-5-nitrobenzanilide is used as an intermediate in the synthesis of pharmaceuticals due to its functional groups that facilitate the creation of a wide range of medicinal compounds.
Used in Dye Industry:
In the dye industry, 2-Amino-5-nitrobenzanilide serves as an intermediate for the production of various dyes, capitalizing on its chemical structure to develop colorants for different applications.
Used in Cosmetic Products:
2-Amino-5-nitrobenzanilide is used as a component in the manufacturing of hair dyes and other cosmetic products, leveraging its chemical properties to enhance the coloration and performance of these products.
Used as a Reagent in Organic Synthesis:
2-AMINO-5-NITROBENZANILIDE functions as a reagent in organic synthesis, where it aids in the formation of desired organic compounds through chemical reactions.
Used as a Research Tool in Chemical and Biochemical Studies:
2-Amino-5-nitrobenzanilide is employed as a research tool in chemical and biochemical studies, providing insights into various chemical reactions and processes due to its unique structure and properties.

InChI:InChI=1/C13H11N3O3/c14-12-7-6-10(16(18)19)8-11(12)13(17)15-9-4-2-1-3-5-9/h1-8H,14H2,(H,15,17)

Upstream product

• 4693-02-1 6-nitroisatoic anhydride 
• 62-53-3 aniline 
• 616-79-5 2-amino-5-nitro-benzoic acid 
• 69123-71-3 2-Amino-5-nitro-benzoyl chloride 

Downstream Products

• 964-25-0 6-nitro-3-phenyl-4(3H)-quinazolinone 
• 21092-27-3 6-nitro-3-phenylquinazoline-2,4(1H,3H)-dione 
• 1632062-57-7 2-(4-ethylpiperazin-1-yl)-6-nitro-3-phenylquinazolin-4(3H)-one 
• 60041-99-8 6-nitro-3-phenylbenzo[d][1,2,3]triazin-4(3H)-one 

Relevant articles and documents

Inhibition of diverse opportunistic viruses by structurally optimized retrograde trafficking inhibitors

Opportunistic viruses are a major problem for immunosuppressed individuals, particularly following organ or stem cell transplantation. Current treatments are non-existent or suffer from problems such as high toxicity or development of resistant strains. We previously published that a trafficking inhibitor that targets a host protein greatly reduces the replication of human cytomegalovirus. This inhibitor was also shown to be moderately effective against polyomaviruses, another family of opportunistic viruses. We have developed a panel of analogues for this inhibitor and have shown that these analogues maintain their high efficacy against HCMV, while substantially lowering the concentration required to inhibit polyomavirus replication. By targeting a host protein these compounds are able to inhibit the replication of two very different viruses. These observations open up the possibility of pan-viral inhibitors for immunosuppressed individuals that are effective against multiple, diverse opportunistic viruses.

One-Pot, Multistep Reactions for the Modular Synthesis of N, N′-Diarylindazol-3-ones

The pot-economic synthesis of N,N′-diarylindazol-3-ones has been developed using readily available isatoic anhydrides, aryl amines, and aryl boronic acids. A Cu-catalyzed oxidative C-N cross-coupling and dehydrogenative N-N formation sequence under an air atmosphere affords indazol-3-one derivatives in good to excellent yields. Such process merges well with the preceding decarboxylative amination reaction, resulting in a more modular and straightforward approach.

NONTOXIC COMPOUNDS FOR THE TREATMENT AND PREVENTION OF HERPESVIRUS INFECTIONS

Compositions for preventing or treating virus infections inhibit the biogenesis of cytoplasmic viral assembly compartment (cVAC). The preferred compounds are dihydroquinazolinones.