3051-84-1

Basic information

• Product Name: Uridine, adenylyl-(3'®5')-
• Synonyms: 3'-Adenylicacid, ester with uridine-(3'®5') (6CI); Adenosine, uridylyl-(5'®3')- (7CI,8CI); 1: PN: US20050272923 PAGE: 4 claimed sequence;Adenosyl-(3'®5')-uridine;Adenylyl-(3'®5')-uridine;Adenylyluridine; NSC 92172; Uridylyl-(5'®3')-adenosine
• CAS NO: 3051-84-1
• Molecular Formula: C19H24 N7 O12 P
• Molecular Weight: 573.413
• Mol File: 3051-84-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Density: 2.23g/cm³
• CAS DataBase Reference: Uridine, adenylyl-(3'®5')-(CAS DataBase Reference)
• NIST Chemistry Reference: Uridine, adenylyl-(3'®5')-(3051-84-1)
• EPA Substance Registry System: Uridine, adenylyl-(3'®5')-(3051-84-1)

Safety Data

• Hazardous Substances Data: 3051-84-1(Hazardous Substances Data)

Usage

General Description

Uridine, adenylyl-(3'®5')- is a chemical compound consisting of uridine and adenosine monophosphate linked together by a 3'-5' phosphodiester bond. It is a nucleotide that forms the building blocks of RNA, playing a critical role in the synthesis of RNA molecules. Uridine is a pyrimidine nucleoside that provides the structural backbone of RNA, while adenosine monophosphate is a key component of energy transfer in cells. Uridine, adenylyl-(3'®5')- is involved in various biological processes, including the regulation of gene expression, cell signaling, and energy metabolism. It may also have potential therapeutic applications in the treatment of cardiovascular diseases and neurological disorders.

Upstream product

• 125444-59-9 2',3'-O-bis-diethylphosphinothioyluridylyl-(5'-3')-adenosine 
• 125444-61-3 2',3'-O-bis-di-n-butylphosphinothioyluridylyl-(5'-3')-adenosine 
• 29108-90-5 2',3'-di-O-acetyl-uridine 
• 35665-55-5 O^5'-acetyl-O^2'_,O3'-hydroxyphosphoryl-adenosine 
• 130-49-4 adenosine 2'-monophosphate 
• 634-01-5 adenosine 2',3'-cyclic monophosphate 
• 74334-87-5 Uridine-2',3',5'-O-tris-diphenylphosphinothioate 
• 74334-86-4 2',3'-O-Isopropylidene-5'-O-diphenylphosphinothioyluridine 
• 362-43-6 2',3'-O-isopropylideneuridine 
• 58-96-8 uridine 
• 125456-06-6 2',3',5'-O-tris-di-n-butylphosphinothioyluridine 
• 125444-60-2 2',3',5'-O-tris-di-n-propylphosphinothioyluridine 
• 125444-58-8 2',3',5'-O-tris-diethylphosphinothioyluridine 
• 84-21-9 adenosine monophosphate 

Downstream Products

• 84-21-9 adenosine monophosphate 
• 130-49-4 adenosine 2'-monophosphate 
• 634-01-5 adenosine 2',3'-cyclic monophosphate 
• 58-96-8 uridine 

Relevant articles and documents

HIGH-YIELD SYNTHESIS OF OLIGORIBONUCLEOTIDES USING o-NITROBENZYL PROTECTION OF 2'-HYDROXYLS

Use of published procedures for photolytic removal of 2'-O-(o-nitrobenzyl) substituents from model oligoribonucleotides results in low yields of fully-deprotected products accompanied by significant amounts of oligomers carrying altered, ultraviolet light-resistant residues derived from the 2'-blocking groups.The efficiency of the deprotection has been found to be depend on pH; the side-reactions are avoided when the photolysis is carried out in solution buffered at pH 3.5.

Some observations relating to the use of 1-aryl-4-alkoxypiperidin-4-yl groups for the protection of the 2′-hydroxy functions in the chemical synthesis of oligoribonucleotides

The comparative rates of acid-catalysed removal often 1-aryl-4-methoxypiperidin-4-yl 8 (R = Me) [including the previously reported Ctmp 5 and Fpmp 6] protecting groups for the 2′-hydroxy functions in oligoribonucleotide synthesis are discussed. These studies have led to the development of the 1-(4-chlorophenyl)-4-ethoxypiperidin-4-yl (Cpep) protecting group 8 (R = Et, R1 = R2 = H, R3 = Cl) which is both more stable than the Ctmp and Fpmp groups at pH 0.5 and more labile at pH 3.75. The influence of the ribonucleoside aglycone on the stability of the 2′-O-Fpmp and 2′-O-Ctmp protecting groups both at low and high pH is examined. The Royal Society of Chemistry 2000.

A new facile synthesis of uridylyl-(5'-3')-adenosine

-