3052-61-7Relevant articles and documents
Emulsion polymerization of vinyl acetate using iodine-transfer and RAFT radical polymerizations
Nomura, Naoki,Shinoda, Keiji,Takasu, Akinori,Nagata, Kenji,Inomata, Katsuhiro
, p. 534 - 545 (2013)
This study deals with control of the molecular weight and molecular weight distribution of poly(vinyl acetate) by iodine-transfer radical polymerization and reversible addition-fragmentation transfer (RAFT) emulsion polymerizations as the first example. E
Synthetic method of dialkyl amino dithiocarbamate alkyl ester
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Paragraph 0010-0016, (2020/02/04)
In organic sulfur compounds, dialkyl amino dithiocarbamate alkyl ester plays a very important role. Researches show that dialkyl amino dithiocarbamate alkyl ester and the derivatives thereof have widebiological characteristics and pharmacological activity. For example, many studies show that the dialkyl amino dithiocarbamate alkyl ester has various activities, including anti-proliferative, anti-glaucoma, antibacterial, antifungal, breast cancer treatment and cholinesterase inhibition activities, and can be used as a myocardial imaging agent. It is known that dialkyl amino dithiocarbamate alkyl ester and the derivatives thereof can be taken as inhibitors of HIV-1 NCp7, antiviral agents, and non-flavonoid TRPV1 antagonists. Dialkyl amino dithiocarbamate alkyl ester has a wide application range, and is massively produced in the world. The invention provides a method for efficiently synthesizing dialkyl amino dithiocarbamate alkyl ester. Under the catalysis of CuI, a chiral quaternary ammonium salt and a dialkyl amino dithioformate are used for C-S cross coupling for the first time, and dialkyl amino dithiocarbamate alkyl ester is prepared. The target product is further converted andcoupled with brominated aromatic hydrocarbons to obtain high-purity enantiomer chiral thioethers. The synthesis process has the advantages of mild reaction conditions, wide universality, no toxicity or danger, high yield, wide substrate range and the like.
A novel electrocatalytic nanocomposite of reduced graphene oxide/silver nanocube hybrid decorated imprinted polymer for ultra-trace sensing of temozolomide
Pathak, Purnendu Kumar,Kumar, Anil,Prasad, Bhim Bali
, p. 13486 - 13496 (2018/08/21)
A new nanocomposite of reduced graphene oxide/silver nanocube hybrid decorated molecularly imprinted polymer at the surface of a screen-printed carbon electrode was developed for the electroanalysis of an anticancerous drug, temozolomide, at the ultra-trace level. For this, a hybrid of reduced graphene oxide/silver nanocubes was successfully obtained through the simultaneous reduction of Ag+ and graphene oxide via simple one-pot green synthesis. Among the various shapes of nanomaterials used in imprinted polymer synthesis, silver nanocubes, as evident from SEM, TEM and, X-ray diffraction methods, have been found to render high surface to volume ratios and a higher electrocatalytic activity. Herein, the synergistic electrocatalytic effect of reduced graphene oxide and silver nanocubes was utilized for decreasing the analyte oxidation overpotential, without any interfacial barrier in between the imprinted film and the electrode surface, owing to the porous texture of the coating. Consequently, approximately 3-fold differential pulse anodic stripping current and ～5-fold electron transfer rate kinetics were obtained on the reduced graphene oxide/silver nanocube hybrid compared with the simple graphene oxide decorated sensor. The covalent Ag-S links, in between the imprinted film and the silver nanocube decorated screen-printed carbon electrode, were crucial for imparting higher stability to the coating of the film. A perfect linearity in the current-concentration profile was observed, in the range 1.09-144.21 ng mL-1, with the detection limits of 0.16 (aqueous), 0.24 (blood plasma), 0.31 (pharmaceutics), and 0.42 (urine) ng mL-1 (S/N = 3). The proposed sensor was found to be useful in aqueous and real samples (human blood plasma, human urine, and pharmaceutics), without any matrix effect, cross-reactivity, or false-positives.
