307512-34-1 Usage
General Description
5-(4-methylphenyl)thieno[2,3-d]pyrimidine-4(3H)-thione is a chemical compound with a molecular formula of C14H10N2S2. It is a heterocyclic compound containing a thieno[2,3-d]pyrimidine skeleton with a thione functional group. 5-(4-METHYLPHENYL)THIENO[2,3-D]PYRIMIDINE-4(3H)-THIONE has potential pharmaceutical properties and may be used in the field of medicinal chemistry for the development of new drugs. Its structure and properties make it an interesting candidate for further research and potential drug discovery.
Check Digit Verification of cas no
The CAS Registry Mumber 307512-34-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,0,7,5,1 and 2 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 307512-34:
(8*3)+(7*0)+(6*7)+(5*5)+(4*1)+(3*2)+(2*3)+(1*4)=111
111 % 10 = 1
So 307512-34-1 is a valid CAS Registry Number.
InChI:InChI=1/C13H10N2S2/c1-8-2-4-9(5-3-8)10-6-17-13-11(10)12(16)14-7-15-13/h2-7H,1H3,(H,14,15,16)
307512-34-1Relevant articles and documents
Synthesis and biological evaluation of substituted (thieno[2,3-d]pyrimidin- 4-ylthio)carboxylic acids as inhibitors of human protein kinase CK2
Golub, Andriy G.,Bdzhola, Volodymyr G.,Briukhovetska, Nadiia V.,Balanda, Anatoliy O.,Kukharenko, Olexander P.,Kotey, Igor M.,Ostrynska, Olga V.,Yarmoluk, Sergiy M.
, p. 870 - 876 (2011/04/22)
A novel series of substituted (thieno[2,3-d]pyrimidin-4-ylthio)carboxylic acids has been synthesized and tested in vitro towards human protein kinase CK2. It was revealed that the most active compounds inhibiting CK2 are 3-{[5-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]thio}propanoic acid and 3-{[5-(4-ethoxyphenyl)thieno[2,3-d]pyrimidin-4-yl]thio}propanoic acid (IC 50 values are 0.1 μM and 0.125 μM, respectively). Structure-activity relationships of 28 tested thienopyrimidine derivatives have been studied and binding mode of this chemical class has been predicted. Evaluation of the inhibitors on seven protein kinases revealed considerable selectivity towards CK2.
