30754-24-6

Basic information

• Synonyms: Heptakis(6-aMino-6-deoxy) b-cyclodextrin;Heptakis(6-amino-6-deoxy)-beta-cyclodextrin;heptakis(6-deoxy-6-amino)beta-CD;β-Cyclodextrin,6A,6B,6C,6D,6E,6F,6G-heptaamino-6A,6B,6C,6D,6E,6F,6G-heptadeoxy;Heptakis(6-amino-6-deoxy)-β-cyclodextrin
• CAS NO: 30754-24-6
• Molecular Formula: C42H77N7O28
• Molecular Weight: 1128.09
• EINECS: 1312995-182-4
• Mol File: 30754-24-6.mol
• Article Data: 19

Chemical Properties

• Melting Point: 208 °C
• Boiling Point: 1453.9±60.0 °C(Predicted)
• Appearance: /
• Density: 1.520±0.06 g/cm3(Predicted)
• PKA: 11.76±0.70(Predicted)
• CAS DataBase Reference: N/A(CAS DataBase Reference)
• NIST Chemistry Reference: N/A(30754-24-6)
• EPA Substance Registry System: N/A(30754-24-6)

Safety Data

• Hazardous Substances Data: 30754-24-6(Hazardous Substances Data)

Usage

Uses

functionalized for condensations with amine-containing reagents, e.g., drugs and proteins.

Upstream product

• 53784-83-1 heptakis(6-bromo-6-deoxy)-β-cyclodextrin 
• 53958-47-7 heptakis-6-azido-6-deoxy-beta-cyclodextrin 

Downstream Products

• 144136-94-7 C₁₁₉H₂₁₀N₁₄O₄₉ 

Relevant articles and documents

Cell transfection with polycationic cyclodextrin vectors

Polycationic cyclodextrins (CDs) were complexed with plasmid DNA and their effectiveness as vectors was tested on COS-7 cells. These CDs were modified with pyridylamino, alkylimidazole, methoxyethylamino or primary amine groups at 6-positions of the glucose units. Uncharged CDs, β-CD, hydroxypropyl- β-CD, and dimethyl-β-CD were also tested, but these did not form stable complexes with the DNA and produced only a slight improvement in transfection level over DNA alone. The polycationic CDs neutralised DNA to form stable nanoparticulate complexes. The transfection efficiency of these CDs was dependent on the substituents present, with the most efficient having either an amino, pyridylamino or butylimidazole group at the 6-positions and unmodified 2- and 3-hydroxyls. One of the most effective vectors, heptakispyridylamino CD, produced a 4000-fold increase in transfection level over DNA alone. Levels were improved 10-fold by use of the endosomolytic agent, chloroquine. The transfection efficiency of the best of these systems in serum equals that of DOTAP in serum. Studies with 32P-labelled plasmid DNA indicate that the polycationic CDs are exceptional promoters of DNA cellular-uptake, the most efficient surpassing DOTAP. Uptake is dependent on proteoglycan-mediated binding to cells. The data imply that intracellular trafficking but not cellular uptake, may be the rate-limiting step in the transfection process. These initial results indicate that CDs are useful templates for further modification to produce molecular constructs capable of enhanced gene delivery.

Method for synthesizing beta-hydroxy carbonyl compound by catalyzing asymmetric Aldol reaction in water phase

The invention discloses a method for synthesizing a beta-hydroxy carbonyl compound by catalyzing asymmetric Aldol reaction in a water phase. The method comprises the following steps: in the water phase, catalyzing ketone and aldehyde with equal molar weig

INHIBITION OF GALECTIN 3 BINDING TO THE AIRWAY EPITHELIAL SURFACE TO TREAT OR PREVENT SEPTIC SHOCK RESULTING FROM INFLUENZA AND SUBSEQUENT PNEUMOCOCCAL PNEUMONIA INFECTION

Galectin 3 inhibitors and methods for treating sepsis using the same are provided herein.