3080-99-7

Basic information

• Product Name: 3,4-DIHYDRO-2H-1,4-BENZOTHIAZINE
• Synonyms: ASINEX-REAG BAS 07625764;AKOS BBS-00002921;3,4-DIHYDRO-2H-BENZO[1,4]THIAZINE;3,4-DIHYDRO-2H-1,4-BENZOTHIAZINE;TIMTEC-BB SBB010332;2,3-dihydro-1,4-benzothiazine;2,3-Dihydrobenzo-1,4-thiazine;2H-1,4-Benzothiazine, 3,4-dihydro-
• CAS NO: 3080-99-7
• Molecular Formula: C₈H₉NS
• Molecular Weight: 151.23
• Product Categories: pharmacetical
• Mol File: 3080-99-7.mol
• Article Data: 33

Chemical Properties

• Boiling Point: 274.4°C at 760 mmHg
• Flash Point: 119.8°C
• Appearance: /
• Density: 1.147g/cm³
• Vapor Pressure: 0.00541mmHg at 25°C
• Refractive Index: 1.604
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 3,4-DIHYDRO-2H-1,4-BENZOTHIAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-DIHYDRO-2H-1,4-BENZOTHIAZINE(3080-99-7)
• EPA Substance Registry System: 3,4-DIHYDRO-2H-1,4-BENZOTHIAZINE(3080-99-7)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 3080-99-7(Hazardous Substances Data)

Usage

Description

3,4-Dihydro-2H-1,4-benzothiazine is a chemical compound that serves as a crucial intermediate in various industrial applications. It is characterized by its unique molecular structure, which contributes to its versatility and reactivity in different chemical processes.

Uses

Used in Organic Synthesis:
3,4-Dihydro-2H-1,4-benzothiazine is used as a key intermediate for the synthesis of various organic compounds. Its chemical properties allow it to participate in a range of reactions, making it a valuable building block in the creation of complex molecules.
Used in Pharmaceutical Industry:
3,4-Dihydro-2H-1,4-benzothiazine is used as a vital component in the development of pharmaceutical drugs. Its unique structure enables it to interact with biological targets, potentially leading to the discovery of new therapeutic agents.
Used in Agrochemicals:
In the agrochemical industry, 3,4-Dihydro-2H-1,4-benzothiazine is used as a starting material for the synthesis of various agrochemical products. Its application in this field highlights its importance in developing compounds that can protect crops and enhance agricultural productivity.
Used in Dyestuff Industry:
3,4-Dihydro-2H-1,4-benzothiazine is also utilized in the dyestuff industry as a raw material for the production of various dyes and pigments. Its chemical properties make it suitable for creating a wide range of colors and shades, contributing to the diversity of dyes available in the market.

InChI:InChI=1/C8H9NS/c1-2-4-8-7(3-1)9-5-6-10-8/h1-4,9H,5-6H2

Upstream product

• 5325-20-2 2H-1,4-benzothiazin-3-one 
• 87012-05-3 4-(Trifluoroacetyl)-2,3-dihydro-1,4-benzothiazine 
• 74-88-4 methyl iodide 
• 106-93-4 ethylene dibromide 
• 137-07-5 2-amino-benzenethiol 
• 6397-16-6 4-acetyl-2,3-dihydrobenzo-1,4-thiazine 
• 1493-27-2 ortho-nitrofluorobenzene 
• 96220-47-2 3-Oxo-3,4-dihydro-2H-1,4-benzothiazine 
• 82595-42-4 2-acetamidophenyl-2-chloroethyl-sulphide 
• 82595-41-3 2-aminophenyl-2-chloroethyl-sulphide 
• 88-73-3 2-Chloronitrobenzene 
• 6375-65-1 (2-nitro-phenylsulfanyl)-acetic acid 
• 6320-02-1 o-bromothiophenol 
• 76800-99-2 2,3-dihydro-4H-benzo[b][1,4]thiazine-4-carbaldehyde 

Downstream Products

• 163155-61-1 (3,4-Dihydro-2H-benzo[1,4]thiazin-5-yl)-(2-fluoro-phenyl)-methanone 
• 6397-22-4 4-(4-nitro-benzoyl)-3,4-dihydro-2H-benzo[1,4]thiazine 
• 461665-68-9 methyl 4-((1-oxido-2,3-dihydro-4H-benzo[b][1,4]thiazin-4-yl)methyl)benzoate 
• 313546-34-8 4-((6bR,10aS)-1,2,6b,9,10,10a-hexahydro-7H-3-thia-8,10b-diaza-fluoranthen-8-yl)-1-(4-fluorophenyl)butan-1-one 
• 1445981-38-3 (S)-(2H-benzo[b][1.4]thiazin-4(3H)-yl)(1-(2,5-dichlorobenzyl)pyrrolidin-2-yl)methanone 
• 1415407-29-2 C₁₉H₁₃Cl₂N₃O₂S 
• 1394833-77-2 (4H-benzo[b][1,4]thiazin-4-yl)(phenyl)methanone 
• 6397-17-7 (2H-benzo[b][1,4]thiazin-4(3H)-yl)(phenyl)methanone 
• 888731-52-0 (4-benzyloxy-3,5-dichlorophenyl)-(2,3-dihydrobenzo[1,4]thiazin-4-yl)-methanone 
• 461665-67-8 methyl 4-((2,3-dihydro-4H-benzo[b][1,4]thiazin-4-yl)methyl)benzoate 
• 727374-97-2 2-(2,3-dihydrobenzo[1,4]-thiazin-4-ylmethyl)-1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol 
• 79602-52-1 4-acetyl-2,3-dihydrobenzo-1,4-thiazine 1,1-dioxide 
• 87012-19-9 4-benzoyl-2-chloro-4H-1,4-benzothiazine 
• 87012-07-5 N-benzoyl-N-<2-(ethylthio)phenyl>ethenamine 

Relevant articles and documents

REACTION BETWEEN N-ACYL-2,3-DIHYDROBENZO-1,4-THIAZINE AND N-ACYLPHENOTIAZINE WITH ORGANOMETALLIC REAGENTS

The title N-acyl-derivatives react with n-BuLi and Grignard reagents leading to products, which, formally, can be considered as derived from a Claisen-type condensation reaction.

Sodium Triethylborohydride-Catalyzed Controlled Reduction of Unactivated Amides to Secondary or Tertiary Amines

The first transition-metal-free catalytic protocol for controlled reduction of amide functions using cheap and bench-stable hydrosilanes as reducing agents has been established. By altering the hydrosilane and solvent, the new method enables the selective cleavage of unactivated C-O bonds in amides and allows the C-N bonds to selectively break via the deacylated cleavage. Overall, this novel process may offer a versatile alternative to current methodologies employing stoichiometric metal systems for the controlled reduction of carboxamides.

Design, Synthesis, Safener Activity, and Molecular Docking of Novel N-Substituted Thiazide/Thiazole Derivatives

A series of novel substituted thiazide/thiazole compounds were designed by splicing active groups and bioisosterism. The title compounds were synthesized via the cyclization, acylation, and carbamylation. All the compounds were characterized by IR, 1H-NMR, 13C-NMR, and HRMS. The single crystal of compound 3f was determined by X-ray crystallography. The biological activity tests indicated that all the compounds showed potential safener activity to the herbicide chlorsulfuron, in which compound 3e showed almost the same level as the commercialized safener AD-67. The molecular docking results were in good agreement with the bioassay results, which demonstrated that compound 3e might compete with chlorsulfuron in the acetolactate synthase active site, causing the herbicide ineffective in maize.