3084-53-5Relevant articles and documents
Influence of Temperature on the Liquid-Liquid Equilibrium of the Ternary System Acetonitrile-2-Furyloxirane-Cyclohexane
Rakotondramanana, Samuel,Borredon, Marie-Elisabeth,Molinier, Jacques
, p. 306 - 308 (1987)
2-Furyloxirane can be obtained by a low hydrated solid-liquid phase transfer process from furfural and a sulfonium salt in basic medium by using acetonitrile as a solvent.It is purified by extraction in a reactive medium with an extracting solvent, cyclohexane.Diagrams on solubility isotherms and tie-line data are given for the ternary system acetonitrile-2-furyloxirane-cyclohexane at 20-30 and 40 deg C.Under these conditions 2-furyloxirane extraction by cyclohexane appears not to depend on temperature.
Redox-Divergent Construction of (Dihydro)thiophenes with DMSO
Chen, Qing-An,He, Gu-Cheng,Hu, Yan-Cheng,Ji, Ding-Wei,Liu, Heng,Zhang, Xiang-Xin,Zhao, Chao-Yang
supporting information, p. 24284 - 24291 (2021/10/08)
Thiophene-based rings are one of the most widely used building blocks for the synthesis of sulfur-containing molecules. Inspired by the redox diversity of these features in nature, we demonstrate herein a redox-divergent construction of dihydrothiophenes, thiophenes, and bromothiophenes from the respective readily available allylic alcohols, dimethyl sulfoxide (DMSO), and HBr. The redox-divergent selectivity could be manipulated mainly by controlling the dosage of DMSO and HBr. Mechanistic studies suggest that DMSO simultaneously acts as an oxidant and a sulfur donor. The synthetic potentials of the products as platform molecules were also demonstrated by various derivatizations, including the preparation of bioactive and functional molecules.
Preparation method of medetomidine and intermediate thereof
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Paragraph 0072; 0073; 0074; 0075, (2017/08/28)
The invention relates to a preparation method of 2-(2, 3-xylyl)-2-methyloxirane. The method is characterized in that the preparation process includes the following reaction shown as the specification, wherein Y is selected from Cl, Br, I, CH3SO4 or HSO4; alkali is selected from KOH, NaOH, LiOH, CsOH, K2CO3, Li2CO3, Cs2CO3, Na2CO3, EtONa, EtOK, (CH3)2CHONa, (CH3)2CHOK, (CH3)3CONa, (CH3)3COK, NH2Na or NH2K. The invention adopts the synthesis method using the 2-(2, 3-xylyl)-2-methyloxirane critical intermediate to prepare medetomidine.