3095-73-6Relevant articles and documents
Girig et al.
, p. 2173,2174, 2175 (1978)
SUPEPANes SUPEFANE COMPOUND, AND PREPARATION METHOD AND APPLICATION THEREOF
-
, (2022/03/27)
The invention discloses a superhanes super-phane compound and a preparation method and application thereof, the superhanes super-phane compound is independently selected from one or more of an imine type superhanes compound, a secondary amine type superhanes compound and a tertiary amine type superhanes compound, and X is selected from a straight-chain carbon chain, an alicyclic group, an aromatic ring group, an alicyclic ring group, an aromatic ring group, a metal complex and a supramolecular macroring. According to the superhanes super-phane compound with the structure and the preparation method and application thereof, the compound has the advantages of being high in symmetry, adjustable in recognition cavity size, multiple in recognition site in a cavity and the like, has liquid fluorescence and solid fluorescence at the same time, and can be applied to ion recognition and separation, neutral molecule capture and cell imaging.
Potent anti-proliferative activities of organochalcogenocyanates towards breast cancer
Banerjee, Kaustav,Padmavathi, Ganesan,Bhattacherjee, Debojit,Saha, Suchismita,Kunnumakkara, Ajaikumar B.,Bhabak, Krishna P.
supporting information, p. 8769 - 8782 (2018/11/30)
The pharmacological importance, particularly the anti-cancer and chemopreventive potentials, of organochalcogen compounds has attracted wide research attention recently. Herein we describe the synthesis of a series of organochalcogenocyanates that have one or more selenocyanate or thiocyanate units in a single molecule. The anti-proliferative activity of these organochalcogenocyanates in different breast cancer cells shows that selenocyanates exhibit much higher anti-proliferative activities than thiocyanates in general. Our study reveals that the activity of benzyl selenocyanate (1, BSC) could be significantly enhanced by 4-nitro substitution (12), which was more selective towards triple-negative breast cancer cells (MDA-MB-231) over other ER+ breast cancer cells (MCF-7 and T-47D). Furthermore, to the best of our knowledge, this is the first report on the synthesis of compounds having more than two selenocyanate units with promising anti-proliferative activities. Our studies further indicate that the apoptotic activities of selenocyanates are associated with modulation of cellular morphology and cell cycle arrest at S-phase. Selenocyanates also inhibited cellular migration and exhibited weak antioxidant activities. An effective binding interaction of compound 12 with serum albumin indicates its feasible transport in the bloodstream for its enhanced anti-cancer properties. Mechanistic studies by western blot analysis demonstrate that benzylic selenocyanates exhibit anti-proliferative activities by modulating key cellular proteins such as Survivin, Bcl-2 and COX-2; this was further supported by molecular docking studies. The results of this study would be helpful in designing suitable chemotherapeutic and chemopreventive drugs in the future.
Composition comprising polymers having a star structure, the polymers, and their use
-
, (2008/06/13)
A composition, comprising, in a physiologically acceptable medium, at least one polymer with a highly specific ordered structure is disclosed. These compositions find a specific application in the field of caring for the skin, in particular of the face, and more especially for treating, that is to say decreasing, erasing and/or smoothing out, wrinkles and/or fine lines of the skin.
