30963-12-3

Basic information

• Product Name: 1-METHYL-1-(3-NITRO-2-PYRIDYL)HYDRAZINE
• Synonyms: 1-METHYL-1-(3-NITRO-2-PYRIDYL)HYDRAZINE;2-(1-Methylhydrazino)-3-nitropyridine;N-METHYL-N-(3-NITROPYRIDIN-2-YL)HYDRAZINE;1-Methyl-1-(3-nitro-2-pyridinyl)hydrazine;1-Methyl-1-(3-nitropyridin-2-yl)hydrazine
• CAS NO: 30963-12-3
• Molecular Formula: C₆H₈N₄O₂
• Molecular Weight: 168.15
• Mol File: 30963-12-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 319°C at 760 mmHg
• Flash Point: 146.7°C
• Appearance: /
• Density: 1.405g/cm³
• Vapor Pressure: 0.000348mmHg at 25°C
• Refractive Index: 1.658
• PKA: 2.55±0.10(Predicted)
• CAS DataBase Reference: 1-METHYL-1-(3-NITRO-2-PYRIDYL)HYDRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-METHYL-1-(3-NITRO-2-PYRIDYL)HYDRAZINE(30963-12-3)
• EPA Substance Registry System: 1-METHYL-1-(3-NITRO-2-PYRIDYL)HYDRAZINE(30963-12-3)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 30963-12-3(Hazardous Substances Data)

Usage

Description

1-METHYL-1-(3-NITRO-2-PYRIDYL)HYDRAZINE is a chemical compound characterized by the molecular formula C7H9N5O2. It is an organic compound that features a nitro group and a pyridine ring, and it is classified as a hydrazine derivative. 1-METHYL-1-(3-NITRO-2-PYRIDYL)HYDRAZINE is predominantly utilized as a building block and intermediate in the realm of organic synthesis. Additionally, it garners interest in the pharmaceutical sector due to its biological activity, with a notable potential as an antitumor agent. However, caution is advised in its handling due to its potential hazards to human health and the environment.

Uses

Used in Organic Synthesis:
1-METHYL-1-(3-NITRO-2-PYRIDYL)HYDRAZINE is used as a building block and intermediate for the synthesis of various organic compounds. Its unique structure, which includes a nitro group and a pyridine ring, makes it a valuable component in the creation of complex organic molecules.
Used in Pharmaceutical Industry:
1-METHYL-1-(3-NITRO-2-PYRIDYL)HYDRAZINE is used as a potential antitumor agent in the pharmaceutical industry. Its biological activity suggests that it may contribute to the development of new drugs for cancer treatment, although further research and development are necessary to fully understand its therapeutic potential and safety profile.
Used in Research and Development:
In the field of research and development, 1-METHYL-1-(3-NITRO-2-PYRIDYL)HYDRAZINE serves as a subject of study for scientists exploring its chemical properties, reactivity, and potential applications in various chemical and pharmaceutical processes. Understanding its behavior can lead to the discovery of new synthetic routes and therapeutic agents.

InChI:InChI=1/C6H8N4O2/c1-9(7)6-5(10(11)12)3-2-4-8-6/h2-4H,7H2,1H3

Upstream product

• 5470-18-8 2-Chloro-3-nitropyridine 
• 60-34-4 methylhydrazine 

Downstream Products

• 110606-69-4 ethyl 1,2,3,4-tetrahydro-1-methyl-3-phenylpyrido<3,2-e>-1,2,4-triazine-3-carboxylate 
• 110606-62-7 ethyl 2-phenylacetate 

Relevant articles and documents

Synthesis of Hydrazinylpyridines via Nucleophilic Aromatic Substitution and Further Transformation to Bicyclo[22.2]octenes Fused with Two N -Aminosuccinimide Moieties

Efficient and reliable synthesis of substituted hydrazinylpyridines in thick-wall ACE tubes via nucleophilic substitution of a chlorine substituent in different chloropyridines is presented. Hydrazine hydrate and alkylhydrazines were used as nucleophiles and simple alcohols and diethyl ether were the only organic solvents necessary, making the process environmentally and user friendly, potentially reaching 100% atomic efficiency. In the next step, transformations of succinic anhydride moieties fused to the bicyclo[2.2.2]octene framework into succinimide moieties via nucleophilic substitution of oxygens were conducted. As nucleophiles two of the synthesized hydrazinylpyridines (2-hydrazinyl-3-nitropyridine and 2-hydrazinyl-5-nitropyridine) and also hydrazine hydrate, phenylhydrazine, and 4-nitrophenylhydrazine were used. Reactions were again carried out in ACE tubes and only simple alcohols, diethyl ether, and acetone were needed as solvents. One of the prepared bicyclo[2.2.2]octene adducts displayed water solubility thus being a promising candidate for future studies as a novel bidentate ligand for various metal cations in aqueous solutions or acting as an unprecedented halogen bond acceptor.

Synthesis of pyrido[3,2-e]pyrrolo[2,1-c][1,2,4]triazines from pyrido[3,2-e][1,2,4]triazine derivatives

In carrying on our interest in heteropolycyclic structures with biological activities, we projected the preparation of compounds containing the pyrido[3,2-e][1,2,4]triazine or pyrido[2,3-b][1,4]triazepine systems. The established synthetic approach for the preparation of latter system led to the triazine derivatives 5a-f while a new bicyclic triazepine structure 6 is accomplished with difficulty. In expanding the pyridotriazine structure, we obtained derivatives of a new tricyclic structure, 5-substituted-6a-ethyloxycarbonyl-5,6,6a,7-tetrahydropyrido[2,3- e]pyrrolo[2,1-c][1,2,4]triazin-9(8H)-ones 8 in which the triazine ring is fused with a pyrrole nucleus. Compounds 5a-f and 8a,b will be tested as potential CNS depressant, antiinflammatory, analgesic and antibacterial agents.