31005-04-6

Basic information

• Product Name: 7-(benzyloxy)-2H-chromen-2-one
• Synonyms: 7-(benzyloxy)-2H-chromen-2-one
• CAS NO: 31005-04-6
• Molecular Formula: C₁₆H₁₂O₃
• Molecular Weight: 252.26468
• Mol File: 31005-04-6.mol
• Article Data: 23

Chemical Properties

• Melting Point: 155 °C
• Boiling Point: 442.1±45.0 °C(Predicted)
• Appearance: /
• Density: 1.250±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 7-(benzyloxy)-2H-chromen-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-(benzyloxy)-2H-chromen-2-one(31005-04-6)
• EPA Substance Registry System: 7-(benzyloxy)-2H-chromen-2-one(31005-04-6)

Safety Data

• Hazardous Substances Data: 31005-04-6(Hazardous Substances Data)

Upstream product

• 93-35-6 7-hydroxy-2H-chromen-2-one 
• 100-39-0 benzyl bromide 
• 100-44-7 benzyl chloride 
• 100-51-6 benzyl alcohol 
• 4279-77-0 S-phenyl hydrogen thiomalonate 
• 52085-14-0 4-benzoxy-salicylaldehyde 
• 620-05-3 iodomethylbenzene 
• 3769-41-3 3-Benzyloxyphenol 
• 623-47-2 propynoic acid ethyl ester 

Downstream Products

• 107052-26-6 (E)-3-(4-Benzyloxy-2-hydroxy-phenyl)-acrylic acid methyl ester 
• 93-35-6 7-hydroxy-2H-chromen-2-one 
• 26486-92-0 6-deoxyisojacareubin 
• 96566-00-6 3,4-dihydro-7-(phenylmethoxy)-1-benzopyran-2-one 
• 94243-90-0 7-(benzyloxy)-2,2-dimethyl-2H-1-benzopyran 
• 1416152-15-2 (E)-butyl 3-(7-(benzyloxy)-2-oxo-2H-chromen-3-yl)acrylate 
• 1417997-51-3 C₁₇H₁₆O₄ 
• 1417997-45-5 C₁₉H₂₀O₄ 
• 11037-15-3 hemiprangosine 
• 15399-67-4 Prangosine 
• 107052-40-4 7-Benzyloxy-6-((2E,6E)-3,7,11-trimethyl-dodeca-2,6,10-trienyl)-chromen-2-one 

Relevant articles and documents

Oxyprenylated Phenylpropanoids Bind to MT1 Melatonin Receptors and Inhibit Breast Cancer Cell Proliferation and Migration

Oxyprenylated compounds (i.e., ferulic acid and coumarin derivatives) demonstrate neuroprotection and anticancer properties as reported in previous studies. We have tested the affinity of oxyprenylated ferulic acid (1-4) and umbelliferone derivatives (5-1

Visible-Light-Induced Direct Csp2-H Radical Trifluoroethylation of Coumarins with 1,1,1-Trifluoro-2-iodoethane (CF3CH2I)

Herein, we developed the first visible-light-induced direct Csp2-H radical 2,2,2-trifluoroethylation of coumarins with commercially available and cheap reagent CF3CH2I at room temperature. This transformation proceeded smoothly under mild conditions and showed excellent functional group compatibility. The synthetic value of the protocol was also demonstrated by the successful functionalization of several pharmaceuticals.

Design, synthesis and biological evaluation of O-alkyl umbelliferone derivatives as pancreatic lipase inhibitors

A series of coumarin derivatives were synthesised through O-alkylation of umbelliferone. These derivatives were screened for their pancreatic lipase (PL) inhibitory potential. The PL inhibitory effect of compounds with various benzyl and long chain alkyl substituents on umbelliferone were analysed. The compound 1g, having the geranyl substituent was found to have better PL inhibitory potential with an IC50 of 21.64 M. The compounds 1a-j were subjected to molecular docking into the crystal structure of human PL. The molecular docking results are in correlation with the in vitro PL inhibition activity, wherein compound 1g showed a higher MolDock score of -122.12 kcal/mol. The long chain alkyl groups were found to have PL inhibition due to additional interactions with lid domain amino acids (Phe215, Tyr114, Phe77), as revealed by molecular docking study.