310404-45-6

Basic information

• Product Name: Pentanoic acid, 2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy]-4-methyl-,(2R)-
• Synonyms: Pentanoic acid, 2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy]-4-methyl-,(2R)-;3-dioxo-2H-isoindol-2-yl)oxy]-4-Methyl-;(R)-2-(1,3-Dioxoisoindolin-2-yloxy)-4-methylpentanoic acid
• CAS NO: 310404-45-6
• Molecular Formula: C₁₄H₁₅NO₅
• Molecular Weight: 277.27
• Product Categories: API intermediates
• Mol File: 310404-45-6.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 445.01°C at 760 mmHg
• Flash Point: 222.935°C
• Appearance: /
• Density: 1.355g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.591
• CAS DataBase Reference: Pentanoic acid, 2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy]-4-methyl-,(2R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Pentanoic acid, 2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy]-4-methyl-,(2R)-(310404-45-6)
• EPA Substance Registry System: Pentanoic acid, 2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy]-4-methyl-,(2R)-(310404-45-6)

Safety Data

• Hazardous Substances Data: 310404-45-6(Hazardous Substances Data)

Usage

General Description

The compound "Pentanoic acid, 2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy]-4-methyl-,(2R)-" is a specific form of an organic chemical molecule. Boasting a sophisticated structure, it involves several functional groups and a chiral center, indicated by the "(2R)-" in its name, which defines its stereospecific orientation. Its structure includes a pentanoic acid (a five-carbon chain acid), an isoindole ring (a fused two-ring structure), and a methyl group attached to the fourth carbon of the pentanoic acid. The "dihydro-1,3-dioxo-" description suggests the isoindole ring carries two carbonyl (C=O) groups. The complexity of its structure implies that this molecule features prominently in specialized applications, likely in the pharmaceutical or agrochemical industry. The exact properties and uses would depend on the specific reactions this compound is involved in.

InChI:InChI=1/C14H15NO5/c1-8(2)7-11(14(18)19)20-15-12(16)9-5-3-4-6-10(9)13(15)17/h3-6,8,11H,7H2,1-2H3,(H,18,19)/t11-/m1/s1

Upstream product

• 310404-40-1 benzyl (R)-4-methyl-2-phthalimidooxypentanoate 
• 380886-35-1 D-tert-butyl 2-phthalimid-N-oxy-4-methylpentanoate 
• 61-90-5 L-leucine 
• 13748-90-8 (S)-2-hydroxyl-3,3-dimethylbutyric acid 
• 3069-50-9 O-acetyl-L-α-hydroxyisocapric acid 
• 3069-52-1 (2S)-2-hydroxy-4-methylpentanoic acid 1,1-dimethylethyl ester 
• 3069-51-0 L-α-Acetoxyisocapronsaeure-tert-butylester 
• 37755-48-9 benzyl (2S)-2-hydroxy-4-methylpentanoate 

Downstream Products

• 627079-37-2 (S)-2-[(R)-2-((R)-2-Benzyloxycarbonylamino-propionylaminooxy)-4-methyl-pentanoylaminooxy]-3-phenyl-propionic acid tert-butyl ester 
• 627079-36-1 (S)-2-[(R)-2-((S)-2-Benzyloxycarbonylamino-propionylaminooxy)-4-methyl-pentanoylaminooxy]-3-phenyl-propionic acid tert-butyl ester 
• 627079-35-0 (S)-2-[(R)-2-(2-Benzyloxycarbonylamino-acetylaminooxy)-4-methyl-pentanoylaminooxy]-3-phenyl-propionic acid tert-butyl ester 
• 500800-65-7 (S)-2-((R)-2-Aminooxy-4-methyl-pentanoylaminooxy)-3-phenyl-propionic acid tert-butyl ester 
• 380886-45-3 D-p-chlorophenyl 2-phthalimidoxy-4-methylpentanoamide 

Relevant articles and documents

Disulfide bond creates a small connecting loop in aminoxy peptide backbone

Disulfide-bond formation between the side chains of cysteine-cysteine pairs is often critical to the folding behavior, stability, and functionality of proteins. In this paper, we report that sulfur atoms can be introduced into the amide groups of aminoxy peptides to form a novel type of disulfide bridge, which creates a connecting loop in the peptide backbone.

α-Aminoxy Oligopeptides: Synthesis, Secondary Structure, and Cytotoxicity of a New Class of Anticancer Foldamers

α-Aminoxy peptides are peptidomimetic foldamers with high proteolytic and conformational stability. To gain an improved synthetic access to α-aminoxy oligopeptides we used a straightforward combination of solution- and solid-phase-supported methods and obtained oligomers that showed a remarkable anticancer activity against a panel of cancer cell lines. We solved the first X-ray crystal structure of an α-aminoxy peptide with multiple turns around the helical axis. The crystal structure revealed a right-handed 28-helical conformation with precisely two residues per turn and a helical pitch of 5.8 ?. By 2D ROESY experiments, molecular dynamics simulations, and CD spectroscopy we were able to identify the 28-helix as the predominant conformation in organic solvents. In aqueous solution, the α-aminoxy peptides exist in the 28-helical conformation at acidic pH, but exhibit remarkable changes in the secondary structure with increasing pH. The most cytotoxic α-aminoxy peptides have an increased propensity to take up a 28-helical conformation in the presence of a model membrane. This indicates a correlation between the 28-helical conformation and the membranolytic activity observed in mode of action studies, thereby providing novel insights in the folding properties and the biological activity of α-aminoxy peptides.

Synthetic Ion Channels

Provided herein are self-assembling compounds that can form ion channels in lipid bilayers or cell membranes and ion-channel-forming compositions comprising the self-assembling compounds. Also provided are methods of making and using the ion channels formed from a plurality of molecules of the self-assembling compounds. Further, provided are methods of treating or preventing conditions and diseases that are related to the dysfunction of ion channels, including chloride channels.