310431-26-6

Basic information

• Product Name: 1-Amino-3-methylpyrrole-2,4-dicarboxylic acid dimethyl ester
• Synonyms: 1-Amino-3-methylpyrrole-2,4-dicarboxylic acid dimethyl ester;1H-Pyrrole-2,4-dicarboxylic acid, 1-aMino-3-Methyl-, 2,4-diMethyl ester;DiMethyl 1-aMino-3-Methyl-1H-pyrrole-2,4-dicarboxylate;Dimethyl 1-Amino-3-Methyl-1H-Pyrrole-2,4-Dicarboxylate(WX618109)
• CAS NO: 310431-26-6
• Molecular Formula: C9H12N2O4
• Molecular Weight: 212.2
• Mol File: 310431-26-6.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 1-Amino-3-methylpyrrole-2,4-dicarboxylic acid dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Amino-3-methylpyrrole-2,4-dicarboxylic acid dimethyl ester(310431-26-6)
• EPA Substance Registry System: 1-Amino-3-methylpyrrole-2,4-dicarboxylic acid dimethyl ester(310431-26-6)

Safety Data

• Hazardous Substances Data: 310431-26-6(Hazardous Substances Data)

Usage

General Description

1-Amino-3-methylpyrrole-2,4-dicarboxylic acid dimethyl ester is a complex organic compound belonging to the class of substances known as pyrroles, which are polycyclic aromatic compounds containing one or more pyrrole rings. Pyrroles are five-membered rings consisting of four carbon atoms and one nitrogen atom. This specific compound has additional functional groups including an amino group, two carboxylic acid groups, and two methyl ester groups. These functional groups may influence its reactivity, solubility, and other properties. Over all, it is highly specialized chemical, likely used in specific industrial or laboratory contexts, but its specific applications and properties would depend on further details.

Upstream product

• 623-43-8 methyl crotonate 
• 623-43-8 crotonic acid methyl ester 
• 40318-15-8 methyl 4-methyl-1H-pyrrole-3-carboxylate 
• 3780-42-5 dimethyl 3-methyl-1H-pyrrole-2,4-dicarboxylate 

Downstream Products

• 1005196-65-5 methyl 4-(2-methyl-5-(methoxycarbamoyl)phenylamino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylate 
• 1005196-67-7 methyl 4-(2-methyl-5-(ethoxycarbamoyl)phenylamino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylate 
• 1005196-62-2 4-((5-(methoxycarbamoyl)-2-methylphenyl)amino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid 
• 1621384-50-6 4-(2-methyl-5-(ethoxycarbamoyl)phenylamino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid 
• 310442-40-1 methyl 4-chloro-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylate 
• 310442-33-2 4-[(3-Hydroxy-4-methylphenyl)amino]-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid 
• 310442-32-1 4-[(3-Hydroxy-4-methylphenyl)amino]-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid methyl ester 
• 310431-29-9 5-methyl-4-oxo-3,4-dihydro-pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid methyl ester 

Relevant articles and documents

Synthesis of carbon-11-labeled 4-(phenylamino)-pyrrolo[2,1-f][1,2,4] triazine derivatives as new potential PET tracers for imaging of p38α mitogen-activated protein kinase

The reference standards methyl 4-(2-methyl-5-(methoxycarbamoyl)phenylamino) -5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylate (10a), methyl 4-(2-methyl-5-(ethoxycarbamoyl)phenylamino)-5-methylpyrrolo[2,1-f][1,2,4] triazine-6-carboxylate (10b) and corre

Synthesis and SAR of 4-(3-hydroxyphenylamino)pyrrolo[2,1-f][1,2,4]triazine based VEGFR-2 kinase inhibitors

A versatile synthesis of the suitably functionalized pyrrolo[2,1-f][1,2,4] triazine nucleus is described. SAR at the C-5 and C-6 positions of the 4-(3-hydroxy-4-methylphenylamino)pyrrolo[2,1-f][1,2,4]triazine template led to compounds with good in vitro potency against VEGFR-2 kinase. Glucuronidation of the phenol group is mitigated by incorporation of a basic amino group on the C-6 side chain of the pyrrolotriazine nucleus.