3107-34-4

Basic information

• Product Name: 2-(Trifluoromethyl)phenylhydrazine hydrochloride
• Synonyms: N'-(2-TRIFLUOROMETHYL-PHENYL)-HYDRAZINIUM, CHLORIDE;BUTTPARK 44\57-17;1-[2-(TRIFLUOROMETHYL)PHENYL]HYDRAZINE HYDROCHLORIDE;2-(TRIFLUOROMETHYL)PHENYLHYDRAZINE HYDROCHLORIDE;2-(TRIFLUOROMETHYL)PHENYLHYDRAZINE MONOHYDROCHLORIDE;alpha,alpha,alpha-Trifluoro-o-tolylhydrazine monohydrochloride;alpha,alpha,alpha-Trifluoro-o-tolylhydrazinemonoHCl;à,à,à-trifluoro-o-tolylhydrazine monohydrochloride
• CAS NO: 3107-34-4
• Molecular Formula: C₇H₇F₃N₂*ClH
• Molecular Weight: 212.6
• EINECS: -0
• Product Categories: Phenylhydrazine
• Mol File: 3107-34-4.mol
• Article Data: 4

Chemical Properties

• Melting Point: 220 °C
• Boiling Point: 221.5 °C at 760 mmHg
• Flash Point: 87.7 °C
• Appearance: white to light yellow crystal powder
• Density: 1.505g/cm3
• Vapor Pressure: 0.107mmHg at 25°C
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Water Solubility: Soluble in water
• BRN: 4582303
• CAS DataBase Reference: 2-(Trifluoromethyl)phenylhydrazine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(Trifluoromethyl)phenylhydrazine hydrochloride(3107-34-4)
• EPA Substance Registry System: 2-(Trifluoromethyl)phenylhydrazine hydrochloride(3107-34-4)

Safety Data

• Hazard Codes: Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39-22
• RIDADR: 2811
• HazardClass: IRRITANT
• Hazardous Substances Data: 3107-34-4(Hazardous Substances Data)

Usage

Chemical Properties

white to light yellow crystal powde

InChI:InChI=1/C7H7F3N2.ClH/c8-7(9,10)5-3-1-2-4-6(5)12-11;/h1-4,12H,11H2;1H

Upstream product

• 88-17-5 2-(trifluoromethyl)benzenamine 
• 395-47-1 [2-(trifluoromethyl)phenyl]magnesium bromide 
• 115171-06-7 C₁₇H₂₃F₃N₂O₄ 

Downstream Products

• 792953-04-9 5-amino-1-(2-(trifluoromethyl)phenyl)-1H-pyrazole-4-carbonitrile 
• 1095263-50-5 (1R,2R)-N-(1-cyanocyclopropyl)-2-{[6-(trifluoromethyl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl]carbonyl}cyclohexanecarboxamide 
• 1245010-56-3 5-(trifluoromethyl)-1-(2-(trifluoromethyl)phenyl)-1H-pyrazole-4-carboxylic acid 
• 138717-70-1 5-Butyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-2-(2-trifluoromethyl-phenyl)-2H-pyrazole-3-carboxylic acid ethyl ester 
• 138732-94-2 5-Propyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-2-(2-trifluoromethyl-phenyl)-2H-pyrazole-3-carboxylic acid ethyl ester 
• 1329422-97-0 1-(2-(trifluoromethyl)phenyl)-1H-pyrazole-4-carbaldehyde 
• 84401-17-2 1-(2-(trifluoromethyl)phenyl)-1H-pyrazole 

Relevant articles and documents

Design, synthesis and pharmacological evaluation of 6,7-disubstituted-4- phenoxyquinoline derivatives as potential antitumor agents

Two series of 6,7-disubstituted-4-phenoxyquinoline derivatives bearing 2,4-imidazolinedione/pyrazolone scaffold were designed, synthesized and evaluated for their c-Met kinase inhibition and cytotoxicity against HT-29, H460, A549, MKN-45, and U87MG cancer cell lines in vitro. The pharmacological data indicated that most of the tested compounds showed moderate to significant cytotoxicity and high selectivity against HT-29, H460 and A549 cancer cell lines as compared with foretinib. The SAR analyses indicated that compounds with halogen groups, especially trifluoromethyl groups at 2-position on the phenyl ring (moiety B) were more effective. In this study, a promising compound 17 (c-Met IC50 = 2.20 nM, a multi-target tyrosine kinase inhibitor) showed the most potent antitumor activities with IC50 values of 0.14 μM, 0.18 μM, 0.09 μM, 0.03 μM, and 1.06 μM against HT-29, H460, A549, MKN-45, and U87MG cell lines, respectively.

Process for the preparation of indazoles

A process for the preparation of aryl hydrazines and indazoles by reacting organometallic regents with azodicarboxylates.