31160-10-8Relevant articles and documents
USE OF HEXAMETHYLPHOSPHORAMIDE (HMPA) IN THE ALKYLATION OF AROMATIC AMINES: SYNTHESIS OF AZETIDINES, PYRROLIDINES, PIPERIDINES AND HEXAHYDROAZEPINES
Juaristi, Eusebio,Madrigal, Domingo
, p. 629 - 636 (2007/10/02)
The direct alkylation of p-toluidine, as a model of aromatic amines, with 1,3-, 1,4-, 1,5- and 1,6-ditosylates, -dibromides or -dimesitylates in HMPA as solvent affords the corresponding cyclic amines.The convenience of this reaction and some observed lim