312-57-2

Basic information

• Product Name: N-(4-Chlorophenyl)-4-fluorobenzenesulfonaMide, 97%
• Synonyms: N-(4-Chlorophenyl)-4-fluorobenzenesulfonaMide, 97%
• CAS NO: 312-57-2
• Molecular Formula: C₁₂H₉ClFNO₂S
• Molecular Weight: 285.7217632
• Mol File: 312-57-2.mol
• Article Data: 4

Chemical Properties

• Melting Point: 146 °C
• Boiling Point: 402.6°C at 760 mmHg
• Flash Point: 197.3°C
• Appearance: /
• Density: 1.467g/cm³
• Vapor Pressure: 1.08E-06mmHg at 25°C
• Refractive Index: 1.625
• PKA: 7.31±0.10(Predicted)
• CAS DataBase Reference: N-(4-Chlorophenyl)-4-fluorobenzenesulfonaMide, 97%(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-Chlorophenyl)-4-fluorobenzenesulfonaMide, 97%(312-57-2)
• EPA Substance Registry System: N-(4-Chlorophenyl)-4-fluorobenzenesulfonaMide, 97%(312-57-2)

Safety Data

• Hazardous Substances Data: 312-57-2(Hazardous Substances Data)

Usage

General Description

N-(4-Chlorophenyl)-4-fluorobenzenesulfonamide, 97%, is a chemical compound that is commonly used as a reagent in organic synthesis and pharmaceutical research. It is a white to off-white solid with a purity of 97% and is known for its high stability and solubility in a variety of organic solvents. N-(4-Chlorophenyl)-4-fluorobenzenesulfonaMide, 97% is often used in the production of pharmaceutical drugs, as well as in the synthesis of various organic compounds in research and industrial settings. It is important to handle and store N-(4-Chlorophenyl)-4-fluorobenzenesulfonamide, 97% with care, following all safety regulations and guidelines to ensure safe handling and use.

InChI:InChI=1/C12H9ClFNO2S/c13-9-1-5-11(6-2-9)15-18(16,17)12-7-3-10(14)4-8-12/h1-8,15H

Upstream product

• 349-88-2 4-Fluorobenzenesulfonyl chloride 
• 106-47-8 4-chloro-aniline 

Downstream Products

• 106914-82-3 Cl(C₆H₄)N(Hg(C₆H₅))SO₂(C₆H₄)F 
• 415963-32-5 N-(4-chlorophenyl)-N-(2-hydrazino-2-oxoethyl)-4-{[2-(4-morpholinyl)ethyl]amino}benzenesulfonamide 
• 415963-31-4 {(4-chloro-phenyl)-[4-(2-morpholin-4-yl-ethylamino)-benzenesulfonyl]-amino}-acetic acid methyl ester 
• 415963-42-7 N-(4-chlorophenyl)-4-[3-(dimethylamino)propoxy]-N-(2-hydrazino-2-oxoethyl)benzenesulfonamide 
• 415963-41-6 methyl [4-chloro-({4-[3-(dimethylamino)propoxy]phenyl}sulfonyl)anilino]acetate 
• 871827-57-5 N-(2-hydrazino-2-oxoethyl)-4-(2-methoxyethoxy)-N-(4-chlorophenyl)benzenesulfonamide 
• 1026481-16-2 ({[4-(2-methoxyethoxy)phenyl]sulfonyl}-4-chloroanilino)acetate 

Relevant articles and documents

Discovery and development of a new class of potent, selective, orally active oxytocin receptor antagonists

We report a novel chemical class of potent oxytocin receptor antagonists showing a high degree of selectivity against the closely related vasopressin receptors (Via, V1b, V2). An initial compound, 7, was shown to be active in an animal model of preterm labor when administered by the intravenous but not by the oral route. Stepwise SAR investigations around the different structural elements revealed one position, the arenesulfonyl moiety, to be amenable to structural changes. Consequently, this position was used to introduce a variety of substituents to improve the physicochemical properties. Some of the resulting analogues were found to be superior to 7 both in terms of potency in vitro and aqueous solubility, which translated into significantly improved efficacy in the animal model after intravenous and oral administration. The best compound, 73, potently inhibited oxytocin-induced uterine contractions in nonpregnant rats and reduced spontaneous uterine contractions in late-term pregnant rats.

19F NMR STUDY OF THE TRANSMISSION CAPACITY OF BINUCLEAR-N(X)SO2-BRIDGING GROUPS

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