31250-16-5Relevant articles and documents
Efficient synthesis of some novel macrocyclic diamides using fast addition method
Sharghi, Hashem,Zare, Abdolkarim
, p. 999 - 1004 (2006)
Synthesis of some new macrocyclic diamides based on catechol scaffold by cyclization reactions between various diamines and 2-[2-(2-chloro-2-oxoethoxy) phenoxy]ethanoyl chloride using fast addition method has been described. The reactions were carried out in short reaction times and the expected macrocycles were obtained in good to high yields. Georg Thieme Verlag Stuttgart.
Physical properties of Eu2+-containing cryptates as contrast agents for ultrahigh-field magnetic resonance imaging
Garcia, Joel,Kuda-Wedagedara, Akhila N. W.,Allen, Matthew J.
, p. 2135 - 2140 (2012)
The kinetic stabilities and relaxivities of a series of Eu 2+-containing cryptates have been investigated. Transmetallation studies, which monitored the change in the longitudinal relaxation rate of water protons in the presence of Ca2+/s
Synthesis and Evaluation of Bifunctional [2.2.2]-Cryptands for Nuclear Medicine Applications
McDonagh, Anthony W.,McNeil, Brooke L.,Patrick, Brian O.,Ramogida, Caterina F.
supporting information, p. 10030 - 10037 (2021/07/19)
For the first time, synthesis of bifunctional [2.2.2]-cryptands (CRYPT) and demonstration of radiolabeling with lead(II) (Pb2+) isotopes are disclosed herein. The synthesis is convenient and high-yielding and gives access to three distinct bifunctional handles (azide (-N3), isothiocyanate (-NCS), and tetrazine (-Tz)) that can enable the construction of radioimmunoconjugates for targeted and pretargeted therapy. Proof-of-principle CRYPT radiolabeling was successful with lead-203 ([203Pb]Pb2+) and demonstrated complexation efficiency superior to that of DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) and efficiency comparable to that of the current industry standard TCMC (1,4,7,10-tetraaza-1,4,7,10-tetra-(2-carbamoylmethyl)-cyclododecane). In vitro human serum stability assays demonstrated excellent [203Pb]Pb-CRYPT stability over 72 h (91.7 ± 0.56%; n = 3). [203Pb]Pb-CRYPT-radioimmunoconjugates were synthesized from the corresponding CRYPT-immunoconjugate or by conjugating [203Pb]Pb-Tz-CRYPT to transcyclooctene modified trastuzumab (TCO-trastuzumab) via the inverse electron-demand Diels-Alder (IEEDA) reaction. This investigation reveals the potential for CRYPT ligands to become new industry standards for therapeutic and diagnostic radiometals in radiopharmaceutical elaboration.
Photolariats: Synthesis, metal ion complexation and photochromism
Ducrot, Aurelien,Verwilst, Peter,Scarpantonio, Luca,Goudet, Sebastien,Kauffmann, Brice,Denisov, Sergey,Jonusauskas, Gediminas,McClenaghan, Nathan D.
experimental part, p. 462 - 472 (2012/09/05)
Photolariat development, as an extension to the family of synthetic photochromic crown ether receptors, or photocrowns, is reported. Incorporated additional chelating groups, namely two anisoles or thioanisoles, contribute in completing the metal ion coor
