312750-63-3

Basic information

• Product Name: O-(N^α-tert-butoxycarbonyl-L-tert-butoxytyrosinyl) O-(S-pivaloyl-2-thioethyl) N,N-diisopropylphosphoramidite
• Synonyms: O-(N^α-tert-butoxycarbonyl-L-tert-butoxytyrosinyl) O-(S-pivaloyl-2-thioethyl) N,N-diisopropylphosphoramidite
• CAS NO: 312750-63-3
• Molecular Weight: 628.811
• Mol File: 312750-63-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: O-(N^α-tert-butoxycarbonyl-L-tert-butoxytyrosinyl) O-(S-pivaloyl-2-thioethyl) N,N-diisopropylphosphoramidite(CAS DataBase Reference)
• NIST Chemistry Reference: O-(N^α-tert-butoxycarbonyl-L-tert-butoxytyrosinyl) O-(S-pivaloyl-2-thioethyl) N,N-diisopropylphosphoramidite(312750-63-3)
• EPA Substance Registry System: O-(N^α-tert-butoxycarbonyl-L-tert-butoxytyrosinyl) O-(S-pivaloyl-2-thioethyl) N,N-diisopropylphosphoramidite(312750-63-3)

Safety Data

• Hazardous Substances Data: 312750-63-3(Hazardous Substances Data)

Upstream product

• 153121-88-1 S-(2-hydroxyethyl) 2,2-dimethylpropanethioate 
• 56183-63-2 bis(diisopropylamino)chlorophosphine 
• 3978-80-1 Boc-Tyr-OH 
• 18938-60-8 (S)-tert-butyl 2-((tert-butoxycarbonyl)amino)-3-(4-hydroxyphenyl)propanoate 
• 200502-01-8 S-pivaloyl-2-thioethyl di(N,N-diisopropylamino)phosphoramidite 

Downstream Products

• 312750-67-7 O-(N^α-tert-butoxycarbonyl-L-tert-butoxytyrosinyl) O-(S-pivaloyl-2-thioethyl) 3'-azido-2',3'-deoxythymidin-5'-yl phosphate 
• 855429-61-7 (S)-3-(4-{[(2S,3S,5R)-3-Azido-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethoxy]-[2-(2,2-dimethyl-propionylsulfanyl)-ethoxy]-phosphanyloxy}-phenyl)-2-tert-butoxycarbonylamino-propionic acid tert-butyl ester 

Relevant articles and documents

Design of new mononucleotide prodrugs: Aryl (SATE) phosphotriester derivatives

Synthesis, biological activities and decomposition kinetics of novel phosphotriester derivatives of 3′-azido-2′,3′-dideoxythymidine (AZT) bearing a S-tButyl-2-thioethyl (tBuSATE) group and L-tyrosinyl residues are reported. All the derivatives appeared to

Rational design of a new series of mixed anti-HIV pronucleotides

MonoSATE aryl phosphotriesters of AZT are able to deliver intracellularly the corresponding 5'-mononucleotide. This process requires activation by an esterase followed by a phosphodiesterase. This finding opens the way to the design of new pronucleotide s