312753-75-6

Basic information

• Product Name: 8-benzyloxy-5-((S)-2-chloro-1-hydroxy-ethyl)-1H-quinolin-2-one
• Synonyms: 8-benzyloxy-5-((S)-2-chloro-1-hydroxy-ethyl)-1H-quinolin-2-one
• CAS NO: 312753-75-6
• Molecular Weight: 329.783
• Mol File: 312753-75-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 8-benzyloxy-5-((S)-2-chloro-1-hydroxy-ethyl)-1H-quinolin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 8-benzyloxy-5-((S)-2-chloro-1-hydroxy-ethyl)-1H-quinolin-2-one(312753-75-6)
• EPA Substance Registry System: 8-benzyloxy-5-((S)-2-chloro-1-hydroxy-ethyl)-1H-quinolin-2-one(312753-75-6)

Safety Data

• Hazardous Substances Data: 312753-75-6(Hazardous Substances Data)

Upstream product

• 63404-86-4 8-benzyloxy-5-[2-chloroacetyl]-1H-quinolin-2-one 
• 100331-89-3 8-benzyloxy-5-(2-bromoacetyl)-1H-quinolin-2-one 

Downstream Products

• 312753-76-7 (S)-8-benzyloxy-5-oxiranyl-1H-quinolin-2-one 

Relevant articles and documents

Scalable ruthenium-catalyzed asymmetric synthesis of a key intermediate for the β2-adrenergic receptor agonist

An enantioselective and robust synthetic process to obtain a useful intermediate for the β2-adrenergic receptor agonist is described. Asymmetric transfer hydrogenation of ketone 1c by (S,S)-3b (Ms-DENEB) afforded chiral alcohol 2c in 71% isolated yield and 99% ee. The deprotection completed the synthesis of (R)-5 in 41% overall yield from 1b, which is readily commercially available.

Beta2-adrenoceptor agonists

Compounds of formula in free or salt or solvate form, where Ar is a group of formula Y is carbon or nitrogen and R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, n, p, q and r are as defined in the specification, their preparation and their use as pharmaceuticals, particularly for the treatment of obstructive or inflammatory airways diseases.