3128-88-9Relevant articles and documents
Electrochemical synthesis of isocyanides and 1,n-diisocyanides
Hess, Ulrich,Brosig,Komenda,Schaefer
, p. 412 - 417 (2007/10/03)
Some isocyanide structures have shown fungicide, antibiotic, insecticide, akarizide and other biological activities. Electrochemical reduction of substituted tosylmethylisocyanides (TosMICs) in acetonitrile/0,1 M tetraalkylammonium supporting-electrolyte at Hg-electrodes led to new alkyl-, aryl and 1,n-diisocyanides in good yields. The reaction proceeds in a two-electron C,S-cleavage, reducing exclusively the tosyl-function. The high selectivity of the corresponding ECE-mechanism is supported by quantum- chemical calculation.