313969-31-2

Basic information

• Product Name: N-Benzhydrylthiophene-2-carboxamide
• Synonyms: N-Benzhydrylthiophene-2-carboxamide;N-(diphenylmethyl)thiophene-2-carboxamide
• CAS NO: 313969-31-2
• Molecular Formula: C18H15NOS
• Molecular Weight: 293.3828
• Mol File: 313969-31-2.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: N-Benzhydrylthiophene-2-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-Benzhydrylthiophene-2-carboxamide(313969-31-2)
• EPA Substance Registry System: N-Benzhydrylthiophene-2-carboxamide(313969-31-2)

Safety Data

• Hazardous Substances Data: 313969-31-2(Hazardous Substances Data)

Usage

General Description

N-benzhydrylthiophene-2-carboxamide is a chemical compound with a molecular formula C22H19NOS. It is a white to off-white solid that is used in research and industry as a building block for the synthesis of pharmaceuticals and agrochemicals. N-benzhydrylthiophene-2-carboxamide is important in the development of new drugs and has potential applications in the treatment of various medical conditions. It has been studied for its anti-inflammatory and anti-cancer properties, as well as its potential as a treatment for neurodegenerative diseases. Additionally, N-benzhydrylthiophene-2-carboxamide has been shown to exhibit pesticidal activity, making it a versatile and valuable compound for various scientific and industrial applications.

Upstream product

• 17698-15-6 N-hydroxythiophene-2-carboxamide 
• 527-72-0 2-thiophenylcarboxylic acid 
• 98-03-3 thiophene-2-carbaldehyde 

Relevant articles and documents

Method for synthesizing amide compound by taking nitrile and diaryl methane as raw materials

The invention discloses a method for synthesizing an amide compound by taking nitrile and diaryl methane as raw materials, the method comprises the following steps: taking diaryl methane as a reaction raw material, nitrile as a raw material and a solvent, 2, 3-dichloro-5, 6-dinitrile group-1, 4-benzoquinone (DDQ) and tert-butyl nitrite (TBN) as catalysts, acid as an auxiliary agent and oxygen as an oxidizing agent, reacting under the conditions of normal temperature, normal pressure and blue light irradiation, and after the reaction is finished, carrying out separation treatment to obtain the amide compound. According to the method, the problem of metal residues in the product can be solved, oxygen is used as a terminal oxidizing agent, the method is environmentally friendly, and energy can be saved.

Preparation method of photocatalytic N-alkylamide compound

The invention belongs to the technical field of organic synthesis, and provides a preparation method of an N-alkylamide compound. According to the method, a dioxazolone compound and an alkane derivative are used as raw materials, a manganese catalyst and an additive react for 12-24 hours in an organic solvent under a mild condition under photocatalysis, and the product is converted into an N-alkylamide compound. The method has the beneficial effects that the raw materials are cheap and easy to obtain, the conditions are mild, the method is environment-friendly, the possibility of industrialization is realized, and the yield of the N-alkylamide compound is high; the N-alkylamide compound can be further functionalized to obtain various compounds, and is applied to development and research of natural products, functional materials and fine chemicals.

Practical Synthesis of N -(Diphenylmethyl)- and N -(1-Adamantyl)amides Directly from Aldehydes via a One-Pot Schmidt and Ritter Reaction Sequence

Nonoxidative and noncoupling reaction conditions have been developed for the synthesis of N-(diphenylmethyl)- and N-(1-adamantyl)amide derivatives directly from aldehydes by employing the concept of a Schmidt and Ritter reaction sequence in a one-pot operation. The reagent mixture consisting of sodium azide and HBF4·OEt2 in acetic acid converts the aldehydes into their respective nitrile analogues which in situ undergo the Ritter reaction with diphenylmethanol or 1-adamantanol to afford the corresponding N-(diphenylmethyl)- or N-(1-adamantyl)amide derivatives in very good yields. The method does not require column chromatographic purification for isolation of the products. With its simple reaction procedure and easy product purification technique, this method outshines earlier conventional two-step methods.