31408-28-3

Basic information

• Product Name: 5-(4-chlorophenyl)pyriMidin-2-aMine
• Synonyms: 5-(4-chlorophenyl)pyriMidin-2-aMine;[5-(4-Chlorophenyl)pyrimidin-2-yl]amine;2-Amino-5-(p-chlorophenyl)pyrimidine
• CAS NO: 31408-28-3
• Molecular Formula: C₁₀H₈ClN₃
• Molecular Weight: 205.64362
• Mol File: 31408-28-3.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Density: 1.323
• CAS DataBase Reference: 5-(4-chlorophenyl)pyriMidin-2-aMine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-chlorophenyl)pyriMidin-2-aMine(31408-28-3)
• EPA Substance Registry System: 5-(4-chlorophenyl)pyriMidin-2-aMine(31408-28-3)

Safety Data

• Hazardous Substances Data: 31408-28-3(Hazardous Substances Data)

Usage

Chemical compound

5-(4-chlorophenyl)pyrimidin-2-amine

Structure

Pyrimidine derivative with a chlorine atom attached to the 4th position of the phenyl ring

Class

Aminopyrimidines

Uses

Synthesis of pharmaceuticals and agrochemicals

Biological activities

Being studied for potential therapeutic effects

Potential applications

Drug development

Versatile compound

Useful for research and development in medicinal chemistry

Upstream product

• 7752-82-1 5-bromo-2-aminopyrimidine 
• 1679-18-1 4-Chlorophenylboronic acid 
• 1445-39-2 2-amino-5-iodopyrimidine 
• 1878-66-6 4-chlorophenylacetic Acid 
• 113-00-8 guanidine nitrate 

Downstream Products

• 742700-90-9 2-amino-5-[4-(4-trifluoromethylbenzylamino)-3-nitrophenyl]pyrimidine 
• 742700-81-8 2-amino-5-[4-(2-methylbenzylamino)-3-nitrophenyl]pyrimidine 
• 742700-82-9 2-amino-5-[4-(4-methylbenzylamino)-3-nitrophenyl]pyrimidine 
• 742700-88-5 5-[4-(4-fluoro-benzylamino)-3-nitro-phenyl]-pyrimidin-2-ylamine 
• 742700-84-1 2-amino-5-[4-(4-methoxybenzylamino)-3-nitrophenyl]pyrimidine 
• 742700-78-3 5-(4-chloro-3-nitrophenyl)-2-pyrimidinamine 

Relevant articles and documents

Preparation of 2,5-disubstituted pyrimidines from vinamidinium salts and synthesis of novel disulfane derivatives

Novel pyrimidine derivatives were prepared from the reaction of 2-substituted 1,3-bis(dimethylamino)-trimethinium salts with thiourea or guanidine in the presence of ethyl-diisopropylamine in ethanol at reflux, and also some 5-substituted pyrimidine-2-thi

Structural studies on bioactive compounds. Part 37. Suzuki coupling of diaminopyrimidines: A new synthesis of the antimalarial drug pyrimethamine

Suzuki reactions have been used successfully to effect cross-coupling of 5-halopyrimidines with 4-chlorobenzeneboronic acid and 2,4-diamino-5-(4-chloro-3-halo)-6-ethylpyrimidines with 4-methoxybenzeneboronic acid. The antimalarial drug pyrimethamine has been prepared by coupling 2,4-diamino-6-ethyl-5-iodopyrimidine with 4-chlorobenzeneboronic acid.