31408-47-6

Basic information

• Product Name: 5-(4-Methoxyphenyl)pyrimidin-2-amine
• Synonyms: 5-(4-METHOXYPHENYL)PYRIMIDIN-2-YLAMINE;5-(4-Methoxyphenyl)pyrimidin-2-ylamine95%;5-(4-methoxyphenyl)pyrimidin-2-amine;5-(4-METHOXYPHENYL)PYRIMIDIN-2-YLAMINE 95%
• CAS NO: 31408-47-6
• Molecular Formula: C₁₁H₁₁N₃O
• Molecular Weight: 201.22
• EINECS: 604-604-1
• Mol File: 31408-47-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 435.6 °C at 760 mmHg
• Flash Point: 217.2 °C
• Appearance: /
• Density: 1.201 g/cm³
• Vapor Pressure: 8.66E-08mmHg at 25°C
• Refractive Index: 1.608
• CAS DataBase Reference: 5-(4-Methoxyphenyl)pyrimidin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-Methoxyphenyl)pyrimidin-2-amine(31408-47-6)
• EPA Substance Registry System: 5-(4-Methoxyphenyl)pyrimidin-2-amine(31408-47-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 31408-47-6(Hazardous Substances Data)

Usage

General Description

5-(4-Methoxyphenyl)pyrimidin-2-amine is a chemical compound with the molecular formula C12H11N3O. It is a pyrimidine derivative with a 4-methoxyphenyl group attached to the 5-position of the pyrimidine ring. 5-(4-Methoxyphenyl)pyrimidin-2-amine is commonly used as a building block in the synthesis of various organic compounds, particularly in the pharmaceutical industry. It has shown potential as a drug candidate for the treatment of various diseases and conditions, including cancer and inflammatory disorders. The specific properties and potential applications of 5-(4-Methoxyphenyl)pyrimidin-2-amine make it an important and valuable chemical in medicinal and organic chemistry research.

InChI:InChI=1/C11H11N3O/c1-15-10-4-2-8(3-5-10)9-6-13-11(12)14-7-9/h2-7H,1H3,(H2,12,13,14)

Upstream product

• 7752-82-1 5-bromo-2-aminopyrimidine 
• 5720-07-0 4-methoxyphenylboronic acid 
• 1445-39-2 2-amino-5-iodopyrimidine 

Downstream Products

• 925438-85-3 5-(4-{3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propoxy}-phenyl)-pyrimidin-2-ylamine 

Relevant articles and documents

Aminoguanidine hydrazone derivatives as non-peptide NPFF1 receptor antagonists reverse opioid induced hyperalgesia

Neuropeptide FF receptors (NPFF1R and NPFF2R) and their endogenous ligand Neuropeptide FF have been shown previously to display anti-opioid properties and to play a critical role in the adverse effects associated with chronic administrations of opiates including the development of opioid-induced hyperalgesia and analgesic tolerance. In this work, we sought to identify novel NPFF receptors ligands by focusing our interest on a series of heterocycles as rigidified non-peptide NPFF receptor ligands, starting from already described aminoguanidine hydrazones (AGH's). Binding experiments and functional assays highlighted AGH 1n and its rigidified analog 2-amino-dihydropyrimidine 22e for in vivo experiments. As earlier shown with the prototypical dipeptide antagonist RF9, both 1n and 22e reduced significantly the long lasting fentanyl-induced hyperalgesia in rodents. Altogether these data indicate that AGH rigidification maintains nanomolar affinities for both NPFF receptors, while improving antagonist character towards NPFF1R.

Reduction of CYP450 inhibition in the 4-[(1H-imidazol-4-yl)methyl] piperidine series of histamine H3 receptor antagonists

A novel series of histamine H3 receptor antagonists based on the 4-[(1H-imidazol-4-yl)methyl]piperidine template displaying low CYP2D6 and CYP3A4 inhibitory profiles has been identified. Structural features responsible for the reduction of P450 activity, a typical liability of 4-substituted imidazoles, have been established.