31413-67-9

Basic information

• Product Name: 3-Methoxy-2-methylpropanenitrile
• Synonyms: 3-Methoxy-2-methylpropanenitrile;3-methoxy-2-methyl-propionitrile
• CAS NO: 31413-67-9
• Molecular Formula: C₅H₉NO
• Molecular Weight: 99.13106
• Mol File: 31413-67-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-Methoxy-2-methylpropanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Methoxy-2-methylpropanenitrile(31413-67-9)
• EPA Substance Registry System: 3-Methoxy-2-methylpropanenitrile(31413-67-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 31413-67-9(Hazardous Substances Data)

Usage

Physical State

Colorless liquid

Odor

Faint

Common Uses

Solvent, intermediate in pharmaceuticals and pesticide synthesis

Flammability

Considered flammable

Safety Precautions

Handle with care, follow proper safety protocols in laboratory or industrial settings

Upstream product

• 67-56-1 methanol 
• 126-98-7 methacrylonitrile 
• 41658-69-9 2-bromo-2-methyl-propionitrile 
• 124-41-4 sodium methylate 

Downstream Products

• 3852-11-7 3-methoxy-2-methylpropionic acid methyl ester 
• 80-62-6 methacrylic acid methyl ester 

Relevant articles and documents

Effect of pressure on sterically congested cyanoalkylation reactions of alcohols

The pressure effect on the phosphine-catalyzed nucleophilic addition of alcohols to unsaturated nitriles is examined. As a general result, pressure promotes these reactions. Their sensitivity to pressure increases with increasing steric congestion of either the alcohol or the nitrile. Activation volumes are found to be very negative pointing not only to a late transition state, but essentially to a considerable electrostriction contribution depending on steric hindrance to ionization. This means that pressures favors formation of the carbanion and attack of the nitrile. The results highlight the synthetic utility of high pressure to remove steric inhibition.