31420-66-3

Basic information

• Product Name: 2-(ethoxycarbonyl)cyclopropanecarboxylic acid
• Synonyms: Trans-1,2-Cyclopropane-Dicarboxylic Acid Mono Ethyl Ester
• CAS NO: 31420-66-3
• Molecular Formula: C₇H₁₀O₄
• Molecular Weight: 158.1519
• Mol File: 31420-66-3.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 266.8°C at 760 mmHg
• Flash Point: 109.6°C
• Density: 1.322g/cm³
• Vapor Pressure: 0.00243mmHg at 25°C
• Refractive Index: 1.505
• CAS DataBase Reference: 2-(ethoxycarbonyl)cyclopropanecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(ethoxycarbonyl)cyclopropanecarboxylic acid(31420-66-3)
• EPA Substance Registry System: 2-(ethoxycarbonyl)cyclopropanecarboxylic acid(31420-66-3)

Safety Data

• Hazardous Substances Data: 31420-66-3(Hazardous Substances Data)

Usage

Description

2-(ethoxycarbonyl)cyclopropanecarboxylic acid is a carboxylic acid derivative with the molecular formula C8H12O4. It features a cyclopropane ring and an ethyl ester group, contributing to its structural rigidity and stability. 2-(ethoxycarbonyl)cyclopropanecarboxylic acid is soluble in organic solvents due to the presence of the ethyl ester group.

Uses

Used in Pharmaceutical Synthesis:
2-(ethoxycarbonyl)cyclopropanecarboxylic acid is used as an intermediate in the synthesis of various pharmaceuticals. Its unique structural features make it a valuable building block for developing new drugs.
Used in Agrochemical Production:
2-(ethoxycarbonyl)cyclopropanecarboxylic acid also serves as an intermediate in the production of agrochemicals, where it can be used to create more complex molecules for agricultural applications.
Used in Organic Synthesis:
2-(ethoxycarbonyl)cyclopropanecarboxylic acid is utilized as a building block in organic synthesis, allowing for the creation of a variety of complex organic molecules for different industries.

Upstream product

• 889461-58-9 diethyl (-)-(1R,2R)-1,2-cyclopropanedicarboxylate 
• 58616-95-8 trans-1,2-cyclopropanedicarboxylic acid 
• 3999-55-1 diethyl trans-cyclopropane-1,2-dicarboxylate 
• 5617-74-3 3-oxabicyclo[3.1.0]hexane-2,4-dione 
• 64-17-5 ethanol 
• 5617-74-3 cis-1,2-cyclopropanedicarboxylic acid anhydride 
• 710-43-0 cis-cyclopropane-1,2-dicarboxylic acid diethyl ester 

Downstream Products

• 613261-19-1 (±)-cis-ethyl 2-((tert-butoxycarbonyl)amino)cyclopropanecarboxylate 
• 1445589-32-1 methyl ((S)-3-methyl-1-((S)-2-(5-(4-(2-((1R,2R)-2-((R)-3-methylmorpholine-4-carbonyl)cyclopropyl)-1H-imidazol-5-yl)-[1,1’-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-1-oxobutan-2-yl)carbamate 
• 1520121-31-6 C₁₂H₁₂N₄O₂ 
• 1520121-17-8 C₁₂H₁₃NO₃ 
• 1520121-14-5 (1R,2R)-N-benzylcyclopropane-1,2-dicarboxamide 
• 1160474-47-4 C₁₂H₁₃NO₃ 
• 84673-46-1 ethyl trans-2-(cyanomethyl)cyclopropanecarboxylate 
• 84673-58-5 trans-2-(cyanomethyl)cyclopropanecarbohydrazide 

Relevant articles and documents

USE OF T-TYPE CALCIUM CHANNEL BLOCKER FOR TREATING PRURITUS

A medicament for treating or preventing pruritus is provided. For the medicament for treating or preventing pruritus, a compound having a blocking action on Cav3.2T-type calcium channels represented by General Formulas (I) to (VI), a tautomer of the compo

Cyclopropane-1,2-dicarboxylic acids as new tools for the biophysical investigation of O-acetylserine sulfhydrylases by fluorimetric methods and saturation transfer difference (STD) NMR

Cysteine is a building block for many biomolecules that are crucial for living organisms. O-Acetylserine sulfhydrylase (OASS), present in bacteria and plants but absent in mammals, catalyzes the last step of cysteine biosynthesis. This enzyme has been dee

Conformationally restrained carbamoylcholine homologues. Synthesis, pharmacology at neuronal nicotinic acetylcholine receptors and biostructural considerations

Exploration of small selective ligands for the nicotinic acetylcholine receptors (nAChRs) based on acetylcholine (ACh) has led to the development of potent agonists with clear preference for the α4β2 nAChR, the most prevalent nAChR subtype in the central nervous system. In this work we present the continuation of these efforts aimed at increasing this subtype selectivity by introduction of conformational restriction in the carbamoylcholine homologue, 3-(dimethylaminobutyl) dimethylcarbamate (DMABC). Our results highlight the importance of the N-carbamoyl substitution in α4β2-subtype selectivity. Moreover, we have confirmed the non-linear conformation of DMABC bound to nAChRs suggested by recent crystal structures of the compound in complex with the Lymnaea stagnalis ACh binding protein.